The Human Yolk Sac and Yolk Sac Tumors

1. Front Matter

   Pages I-XVI

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2. Comparative Development of the Mammalian Yolk Sac

   • B. F. King, A. C. Enders

   Pages 1-32

3. Development of the Human Yolk Sac

   • A. C. Enders, B. F. King

   Pages 33-47

4. Histology of the Secondary Human Yolk Sac with Special Reference to Hematopoiesis

   • T. Takashina

   Pages 48-69

5. Kinetics of Hematopoiesis in the Human Yolk Sac

   • G. Migliaccio, A. R. Migliaccio

   Pages 70-83

6. Macrophages in the Human Yolk Sac

   • H. Enzan

   Pages 84-108

7. α-Fetoprotein and Other Proteins in the Human Yolk Sac

   • D. Buffe, C. Rimbaut, J. A. Gaillard

   Pages 109-125

8. Yolk Sac Abnormalities: A Clinical Review

   • N. Exalto

   Pages 126-134

9. Experimental Models of Injury in the Mammalian Yolk Sac

   • E. A. Reece, E. Pinter, F. Naftolin

   Pages 135-160

10. Ultrasonography of the Human Yolk Sac

    • E. Ferrazzi, S. Garbo

    Pages 161-173

11. Morphological Changes of the Secondary Human Yolk Sac in Early Pregnancy Wastage

    • F. F. Nogales, E. Beltran, F. Gonzalez

    Pages 174-194

12. Yolk Sac Carcinoma: History of the Concept and the Experimental Models

    • I. Damjanov, A. Damjanov, U. M. Wewer

    Pages 195-215

13. Immunohistochemical Markers of Yolk Sac Tumors

    • E. Saksela

    Pages 216-227

14. Pathology of Ovarian Yolk Sac Tumors

    • F. F. Nogales, E. Beltran, M. Pavcovich

    Pages 228-244

15. Clinical Features and Management of Gynecologic Yolk Sac Tumors

    • D. M. Gershenson

    Pages 245-261

16. Pathology of Testicular Yolk Sac Tumors

    • A. Talerman

    Pages 262-284

17. Pathology of Extragonadal Yolk Sac Tumors

    • P. B. Clement, R. H. Young

    Pages 285-308

18. Unusual Patterns, Subtypes, and Differential Diagnosis of Gonadal Yolk Sac Tumors

    • R. H. Young, R. E. Scully

    Pages 309-342

19. Clinical Features and Management of Testicular and Extragonadal Yolk Sac Tumors

    • F. H. Dexeus, S. Ogden, A. Cangir, J. Ro, C. J. Logothetis

    Pages 343-358

20. Back Matter

    Pages 359-367

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I am honored to have been invited to write a foreword for this book, because tumors of the yolk sac have been a preoccupation of mine since the days of my residency, now more than 3 decades ago. At that time, a 3-year-old boy died of a testicular cancer of unknown histo­ genesis. It was bad enough that the child died, but it bothered me even more that medical science did not know the histogenesis of the tumor that destroyed him, and I decided to study testicular cancer. For re­ search training I sought out F. J. Dixon, who had written the Armed Forces Fascicle on testicular tumors. Dr. Dixon and I showed that embryonal carcinoma was a multipoten­ tial malignant stem cell that differentiated into the three embryonic germ layers of murine teratocarcinoma. This led to the idea that the normal counterpart of embryonal carcinoma must also be multi­ potent, and we focused on the preimplantation embryo for the histo­ genesis of the tumor. This idea was strengthened by the discovery that embryonal carcinoma cells made embryoid bodies in the ascites and it was possible to observe the development of these bodies in vitro. These observations led to the idea that embryonal carcinoma was a caricature (gross misrepresentation) of early development, and car­ cinomas in general were a caricature of the process of renewal of their normal counterpart.

• Dottersack
• Dottersacktumoren
• Therapie
• biochemistry
• biology
• birth
• histology
• histopathology
• imaging
• imaging techniques
• pathology
• pregnancy
• ultrasound
• yolk sac
• yolk sac tumors

• Head of Department, University Hospital, Granada, Spain

  Francisco F. Nogales

Policies and ethics