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Pathogenesis of Shigellosis

  • Book
  • © 1992

Overview

Editors:
  1. P. J. Sansonetti

    1. Unité de Pathogénie Microbienne Moleculaire, Institut Pasteur, Paris Cedex 15, France

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Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 180)

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Table of contents (6 chapters)

  1. Front Matter

    Pages I-IX
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  2. Molecular and Cellular Biology of Shigella flexneri Invasiveness: From Cell Assay Systems to Shigellosis

    • P. J. Sansonetti
    Pages 1-19

  3. The Large Virulence Plasmid of Shigella

    • C. Sasakawa, J. M. Buysse, H. Watanabe
    Pages 21-44

  4. Shigella Lipopolysaccharide: Structure, Genetics, and Vaccine Development

    • H. N. Brahmbhatt, A. A. Lindberg, K. N. Timmis
    Pages 45-64

  5. Shiga Toxin: Biochemistry, Genetics, Mode of Action, and Role in Pathogenesis

    • A. D. O’brien, V. L. Tesh, A. Donohue-Rolfe, M. P. Jackson, S. Olsnes, K. Sandvig et al.
    Pages 65-94

  6. Environmental Regulation of Shigella Virulence

    • A. T. Maurelli, A. E. Hromockyj, M. L. Bernardini
    Pages 95-116

  7. Pathogenesis and Immunology in Shigellosis: Applications for Vaccine Development

    • T. L. Hale, D. F. Keren
    Pages 117-137

  8. Back Matter

    Pages 139-143
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Keywords

About this book

Shigellosis is present all over the world. Anyone traveling in developing countries knows that the control of this invasive disease of the intestine is a priority task for physicians and public health authorities. Victims are essentially young children, and complications such as the hemolytic uremic syndrome make shigellosis a systemic disease rather than simply an infection of the colonic mucosa. However, "Westerners" should not consider shigeJlosis as an unlikely threat of the tropics. The disease arises in industrialized countries as soon as breaches in sanitation appear. A few months ago, at least 500 people developed shigellosis in northern France in an outbreak of Shigella sonnei infection due to accidental contamination of an urban water delivery system. The pathogenesis of shigellosis is an extraordinary topic of research because study of the invasion of the colonic mucosa addresses fundamental questions on. the molecular and cellular mechanisms by which a bacterial pathogen can pene­ trate non phagocytic cells, survive, multiply, spread in the intra­ cellular compartment, and eventually kill host cells. Further development of the infection within subepithelial tissues as well as the mechanisms that contribute to the eradication of this process have barely been studied.

Editors and Affiliations

  • UnitĂ© de PathogĂ©nie Microbienne Moleculaire, Institut Pasteur, Paris Cedex 15, France

    P. J. Sansonetti

Bibliographic Information

  • Book Title: Pathogenesis of Shigellosis

  • Editors: P. J. Sansonetti

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-77238-2

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1992

  • Softcover ISBN: 978-3-642-77240-5Published: 16 December 2011

  • eBook ISBN: 978-3-642-77238-2Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: X, 143

  • Number of Illustrations: 9 b/w illustrations

  • Topics: Medical Microbiology, Internal Medicine, Immunology, Cell Biology

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