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DNA Replication: The Regulatory Mechanisms

  • Conference proceedings
  • © 1992

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Table of contents (35 papers)

  1. Introduction

  2. Cellular DNA Replication

    1. Origin identification in mammalian chromosomes

    2. Origin structure. function and modification

    3. Initiator — replication origin recognition

Keywords

About this book

DNA replication is a key event in the cell cycle. Although our knowledge is far from complete and many elusive regulatory mechanisms still remain beyondour grasp, many enzymes and a multiplicity of biochemical mechanisms involved have been discovered. Recent findings in E. coli have confirmed and yet surpassed the original hypothesis of F. Jacob. In yeast and higher eucaryotes, the apparent redundancy in putative origins and initiators has made an estimation of the importance of each identified element difficult to access. In spite of well established methodologies - which are also described in the book - the origin identification in mammalian chromosomes is still a controversial subject. On the other hand, considerable advances have been made in our understanding of virus DNA replication and this continues to deepen and broaden our understanding of the controls of cellular DNA replication.

Editors and Affiliations

  • Institut Jacques Monod, CNRS, Université Paris 7, Paris Cedex 05, France

    Patrick Hughes, Masamichi Kohiyama

  • Institut für Biochemie, München 2, Germany

    Ellen Fanning

Bibliographic Information

  • Book Title: DNA Replication: The Regulatory Mechanisms

  • Editors: Patrick Hughes, Ellen Fanning, Masamichi Kohiyama

  • DOI: https://doi.org/10.1007/978-3-642-76988-7

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1992

  • Softcover ISBN: 978-3-642-76990-0Published: 27 December 2011

  • eBook ISBN: 978-3-642-76988-7Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XX, 422

  • Topics: Cell Biology, Biochemistry, general

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