Theoretical and Experimental Insights into Immunology

1. Front Matter

   Pages I-XVII

   PDF

2. General Perspectives

   1. Front Matter

      Pages 1-1

      PDF

   2. Computer Modelling of the Immune System: Who are the “Fruitori”?

      • Franco Celada

      Pages 3-13

   3. Is the Function of the Immune System only to Protect?

      • Edward S. Golub

      Pages 15-26

   4. The Immune System in an Evolutionary Perspective

      • J. Stewart

      Pages 27-47

   5. A Simulation of the Humoral Immune System

      • Philip E. Seiden, Franco Celada

      Pages 49-62

   6. Probability of Self-Nonself Discrimination

      • J. K. Percus, Ora E. Percus, Alan S. Perelson

      Pages 63-70

   7. Contextual Discrimination of Antigens by the Immune System: Towards a Unifying Hypothesis

      • Zvi Grossman

      Pages 71-89

3. T Cell Models

   1. Front Matter

      Pages 91-91

      PDF

   2. Theoretical Insight into Antigen-Induced T-Cell Unresponsiveness

      • M. Kaufman, F. Andris, O. Leo

      Pages 93-115

   3. Interaction of Interleukin-2 with its Cell Surface Receptors: Interpretation of Equilibrium Binding Experiments via Scatchard Plots

      • Alan S. Perelson, Byron Goldstein

      Pages 117-148

   4. T Memory Cells in a Model of T Cell Memory

      • Angela R. McLean

      Pages 149-162

   5. A “Minimal” Basic T-Cell Model

      • Karl E. Kürten

      Pages 163-170

   6. Mathematical Modeling of Th1-Th2 Dynamics

      • Benoit F. Morel, Jayant Kalagnanam, Penelope A. Morel

      Pages 171-190

   7. Complex Outcomes in Mouse Leishmaniasis: A Model for the Dynamics of the TH1 Response

      • A. Nicola Schweitzer, Jonathan Swinton, Roy M. Anderson

      Pages 191-202

4. Networks and Attractors

   1. Front Matter

      Pages 203-203

      PDF

   2. Generic Modelling of the Immune Network

      • Gérard Weisbuch, Avidan U. Neumann

      Pages 205-222

   3. Growth and Recruitment in the Immune Network

      • Rob J. De Boer, Pauline Hogeweg, Alan S. Perelson

      Pages 223-247

   4. Memory B Cells Stabilize Cycles in a Repressive Network

      • Ulrich Behn, J. Leo van Hemmen, Bernhard Sulzer

      Pages 249-260

5. From Molecular to Cellular Immunology

   1. Front Matter

      Pages 261-261

      PDF

Immunology is largely a science of observation and experimentation, and these approaches have lead to great increases in our knowledge of the genes, molecules and cells of the immune system. This book is an up-to-date discussion of the current state of modelling and theoretical work in immunology, of the impact of theory on experiment, and of future directions for theoretical research. Among the topics discussed are the function and evolution of the immune system, computer modelling of the humoral immune response and of idiotypic networks and idiotypic mimicry, T-cell memory, cryptic peptides, new views and models of AIDS and autoimmunity, and the shaping of the immune repertoire by early presented antigens and self immunoglobulin.

• AIDS
• Antigen
• Autoimmunity
• Autoimmunität
• Cell Recognition
• Immune System
• Immunity
• Immunologie
• Immunology
• T-Cells
• T-Zellen
• Zellerkennung

• Theoretical Division, Los Alamos National Laboratory, Los Alamos, USA

  Alan S. Perelson

• Laboratoire de Physique Statistique, Ecole Normale Supérieure, Paris Cédex 5, France

  Gérard Weisbuch

Policies and ethics