Physiology and Pharmacology of the Blood-Brain Barrier

1. Front Matter

   Pages I-XXIII

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2. Ultrastructure of Brain Endothelium

   • M. W. Brightman

   Pages 1-22

3. Methods of Study

   • Q. R. Smith

   Pages 23-52

4. Diffusional and Osmotic Permeability to Water

   • P. A. Fraser

   Pages 53-64

5. Blood-Brain Glucose Transfer

   • A. Gjedde

   Pages 65-115

6. Transport of Amino Acids

   • J.-M. Lefauconnier

   Pages 117-150

7. Peptides and the Blood-Brain Barrier

   • D. J. Begley

   Pages 151-203

8. The Movement of Vitamins Into the Brain

   • O. E. Pratt

   Pages 205-220

9. Electrolyte Transport

   • G. P. Schielke, A. L. Betz

   Pages 221-243

10. Secretion and Bulk Flow of Interstitial Fluid

    • H. F. Cserr, C. S. Patlak

    Pages 245-261

11. Trace Metal Transport at the Blood-Brain Barrier

    • M. W. B. Bradbury

    Pages 263-278

12. Transport of Drugs

    • P. J. Robinson, S. I. Rapoport

    Pages 279-300

13. Clinical Assessment of Blood-Brain Barrier Permeability: Magnetic Resonance Imaging

    • D. Barnes

    Pages 301-312

14. Clinical Assessment of the Blood-Brain Barrier: Positron Emission Tomography

    • D. J. Brooks

    Pages 313-325

15. Ontogenetic Development of Brain Barrier Mechanisms

    • N. R. Saunders

    Pages 327-369

16. Comparative Physiology of the Blood-Brain Barrier

    • N. J. Abbott

    Pages 371-396

17. Immunology of Brain Endothelium and the Blood-Brain Barrier

    • D. K. Male

    Pages 397-415

18. The Blood-Brain Barrier In Vitro and in Culture

    • J. J. Laterra, G. W. Goldstein

    Pages 417-437

19. Opening of the Barrier in Cerebral Pathology

    • P. J. Luthert

    Pages 439-457

20. Experimental Manipulation of the Blood-Brain ”and Blood-Retinal Barriers

    • J. Greenwood

    Pages 459-486

The blood-brain barrier is still not completely understood and therefore the subject of fascinating study. How are endogenous substances transported through the blood-brain barrier? What are the known therapeutic and toxic agents? How are they transported across cerebral microvessels? The discussion of these and other questions with far-reaching consequences for all neuroscientists can be found in this volume. This authoritative and up-to-date review of the blood-brain barrier gives a proper understanding of the topic. The experimental principles, the results of very recent research, as well as the implications that experimental research has for clinical treatment are thoroughly covered. Information is given on: - new findings based on classical physiological and pharmacological techniques, - results obtained from brain capillaries in vitro and in culture, - results obtained from the new scanning techniques (PET and MRI), - the immunology of the blood-brain barrier, - trace metal transport, - the pathological breakdown of the barrier and - the modification of drugs to increase their entry into the brain. Here is a source of information that is invaluable to specialists concerned with basic research in the neurosciences, with the design of neuropharmacological agents, with the radiological diagnosis of cerebral pathology or with the treatment of cerebral lesions!

• Amino acid
• Blood-Brain Barrier
• Blut-Hirn-Schranke
• Cerebral Capillaries
• Cerebral Endothelium
• Hirnkreislauf
• Permeability of Blood-Brain Barrier
• diagnosis
• neuroscience
• physiology
• positron emission tomography

• Physiology Group Biomedical Sciences Division King’s College London, University of London, London, Great Britain

  Michael W. B. Bradbury

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