Interferons: Mechanisms of Action and Role in Cancer Therapy

1. Front Matter

   Pages i-vii

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2. Introduction

   • Derek Crowther

   Pages 1-2

3. The Interferons: Their Properties and Clinical Role — An Overview

   • Penella J. Woll, Derek Crowther

   Pages 3-13

4. Interferons: Biosynthesis, Physiological Roles, Mechanisms of Induction and Response

   • George R. Stark

   Pages 15-23

5. The Mechanisms of Action and the Role of Alpha Interferon in the Therapy of Myeloma

   • A. Österborg, H. Mellstedt

   Pages 25-33

6. The Role of Interferon in the Management of Low-Grade Lymphoma

   • Ama Rohatiner

   Pages 35-41

7. The Role of Interferons in Neuroendocrine Tumours and Aspects of Mechanisms of Action

   • Kjell E. Öberg

   Pages 43-52

8. The Interferons plus Other Modalities of Cancer Therapy

   • John Wagstaff

   Pages 53-63

A great deal of new information has been obtained during the past four years, and this monograph provides a clear and well reviewed update on biochemical mechanisms and the results of important new clinical studies using the interferons. Reviews include what is presently known about the biosynthesis, physiological role and mechanisms of action of the interferons (alpha, beta, gamma). New biochemical information on interferon-receptor interactions and signalling pathways is provided. The pharmacokinetic considerations in treating leukemia, lymphoma, myeloma, neuroendocrine tumors and other solid tumors are reviewed with special emphasis on studies of adjuvant chemotherapy in malignancies of the immune system.

• Lymphom
• Myeloma
• Tumor
• alpha
• beta
• cancer
• cancer therapy
• chemotherapy
• gamma
• interferon
• leukemia
• lymphoma
• neurocrine tumors
• neuroendocrine Tumoren
• neuroendocrine tumor
• Radiaton Oncology

• CRC Department of Medical Oncology, Christie Hospital NHS Trust, Manchester, UK

  Derek Crowther

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