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Cholecystokinin Antagonists in Gastroenterology

Basic and Clinical Status

  • Book
  • © 1991

Overview

Editors:
  1. Guido Adler

    1. Abteilung Innere Medizin I, Medizinische Klinik und Poliklinik Oberer Eselsberg, Ulm, Germany

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  2. Christoph Beglinger

    1. Abteilung für Gastroenterologie, Universitätsklinik, Basel, Switzerland

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Table of contents (26 chapters)

  1. Front Matter

    Pages I-XIII
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  2. Biology of CCK

    1. Front Matter

      Pages 1-1
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    2. Biochemistry of CCK

      • G. J. Dockray, A. Varro
      Pages 3-9

    3. The Morphological Localization of Cholecystokinin and Its Binding Sites in the Diffuse Neuroendocrine System

      • A. E. Bishop, Y. D. Zhao, D. R. Springall, J. M. Polak
      Pages 10-26

    4. Heterogeneity of CCK Receptors: Classification and Characterization

      • L. J. Miller
      Pages 27-34

    5. Biological Actions of CCK in the Gastrointestinal Tract

      • T. E. Solomon
      Pages 35-43

    6. Biological Actions of CCK in the Central Nervous System

      • R. Y. Wang, C. R. Ashby Jr.
      Pages 44-55

    7. Vagally Mediated Actions of CCK

      • G. J. Dockray
      Pages 56-62

  3. Chemistry of CCK Antagonists

    1. Front Matter

      Pages 63-63
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    2. Pentanoic Acid Derivatives

      • L. C. Rovati
      Pages 65-69

    3. Characterization of MK-329

      • R. G. Berlin, R. M. Freidinger
      Pages 70-79

    4. Boc-Tyr(SO3H)-Nle-Gly-Trp-Nle-Asp-2-Phenylethyl Ester — JMV180: A Unique CCK Analogue with Different Actions on High- and Low-Affinity CCK Receptors

      • J. Martinez, M-C. Galas, M-F. Lignon, M. Rodriguez, P. Fulcrand
      Pages 80-90

  4. Physiological Application of CCK Antagonists

    1. Front Matter

      Pages 91-91
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    2. Cholecystokinin Receptor Antagonists In Vitro

      • R. T. Jensen, J. D. Gardner
      Pages 93-111

    3. Effects of Cholecystokinin Receptor Antagonists in Animal Models

      • C. Niederau, M. Niederau, R. Lüthen, G. Strohmeyer, J. H. Grendell
      Pages 112-126

    4. Role of Cholecystokinin in Regulating Gallbladder Contraction and Pancreatic Secretion in Man: Studies with Loxiglumide

      • C. Beglinger, G. Adler
      Pages 127-134

    5. Effect of MK-329 on Pancreatic Secretion in Man

      • P. Cantor
      Pages 135-142

    6. Regulation of Gallbladder Contraction and Gastric Emptying by the CCK Receptor Antagonist MK-329

      • R. A. Liddle
      Pages 143-151

    7. Regulation of CCK Release by Bile Acids

      • I. Koop
      Pages 152-158

    8. Pyloric Cholecystokinin Receptors

      • T. H. Moran, L. Shnayder, G. J. Schwartz, P. R. McHugh
      Pages 159-164
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Keywords

About this book

A new presentation of physiological regulatory mechanisms and therapeutic applications is given in this book. It represents a collection of the most up-to-date information in cholecystokinin (CCK) research, especially focusing on the development and characterization of CCK antagonists. The book contains chapters on the synthesis, biochemical and pharmacological characterization of potent and selective CCK antagonists as well as physiological applications of these compounds. The last section of the book is devoted to the involvement of CCK in pathological states and potential clinical applications of CCK antagonists.

Editors and Affiliations

  • Abteilung Innere Medizin I, Medizinische Klinik und Poliklinik Oberer Eselsberg, Ulm, Germany

    Guido Adler

  • Abteilung für Gastroenterologie, Universitätsklinik, Basel, Switzerland

    Christoph Beglinger

Bibliographic Information

  • Book Title: Cholecystokinin Antagonists in Gastroenterology

  • Book Subtitle: Basic and Clinical Status

  • Editors: Guido Adler, Christoph Beglinger

  • DOI: https://doi.org/10.1007/978-3-642-76362-5

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1991

  • Softcover ISBN: 978-3-642-76364-9Published: 21 December 2011

  • eBook ISBN: 978-3-642-76362-5Published: 29 June 2013

  • Edition Number: 1

  • Number of Pages: XIII, 233

  • Topics: Gastroenterology, Hepatology, Human Physiology, Biochemistry, general, Pharmacology/Toxicology

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