Cerebral Ischemia and Dementia

1. Front Matter

   Pages I-XV

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2. Introduction

   1. Front Matter

      Pages 1-1

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   2. How Does Cerebrovascular Disease Cause Dementia?

      • M. D. O’Brien

      Pages 3-6

3. Epidemiology

   1. Front Matter

      Pages 7-7

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   2. The Epidemiology of Vascular Dementia

      • G. C. Román

      Pages 9-15

   3. Epidemiology of Vascular Dementia and Stroke in Akita, Japan

      • K. Suzuki, T. Kutsuzawa, K. Nakajima, S. Hatano

      Pages 16-24

   4. Dementia in Stroke Survivors

      • T. K. Tatemichi, M. A. Foulkes, J. P. Mohr, J. R. Hewitt, D. B. Hier, T. R. Price et al.

      Pages 25-30

4. Pathology

   1. Front Matter

      Pages 31-31

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   2. The Anatomical Substrate of Ischemic Vascular Dementia

      • J. H. Garcia, G. G. Brown

      Pages 33-38

   3. Vascular Dementia: The Search for a Correlate

      • J. Cervós-Navarro

      Pages 39-53

   4. Incomplete Infarction Is an Important Component in Cerebrovascular Dementia

      • A. Brun, L. Gustafson

      Pages 54-59

5. Risk Factors

   1. Front Matter

      Pages 61-61

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   2. Molecular Biology of Atherothrombotic Brain Infarction and Its Role in Vascular Dementia

      • F. M. Yatsu, R. Kasturi, R. Alam, J. Kraus, S. Rogers, T. J. DeGraba et al.

      Pages 63-68

   3. Cellular Aspects of Atherosclerosis and Approaches to Intervention: A Mechanism to Reduce Stroke and Vascular Dementia Risk

      • M. Fisher

      Pages 69-76

   4. Inhibition of Atherogenesis In Vivo and In Vitro

      • E. L. Betz

      Pages 77-84

6. Biochemistry and Pharmacology

   1. Front Matter

      Pages 85-85

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   2. Alzheimer’s Disease: Role of Energy Metabolism and Treatment of Symptoms

      • D. M. Bowen, P. T. Francis, S. L. Lowe, M. N. Pangalos, A. W. Procter, J. E. Steele

      Pages 87-93

   3. Neurochemical Changes in Brains from Patients with Vascular Dementia

      • C. G. Gottfries, I. Alafuzoff, A. Carlsson, S.-Å. Eckernäs, I. Karlsson, L. Oreland et al.

      Pages 94-102

   4. Subcortical Changes Following Ischaemic and Other Lesions of Cerebral Cortical Structures: Trophic Mechanisms and Neuronal Degeneration

      • M. V. Sofroniew, C. N. Svendsen

      Pages 103-120

7. Experimental I

   1. Front Matter

      Pages 121-121

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In contrast to dementia of the Alzheimer type, the subject of dementia subsequent to cerebral ischemia has been discussed rather rarely. Now this book provides a summary of the brain morphology, neurochemistry and clinical aspects of dementia subsequent to cerebral ischemia. The contributions discuss the similarities and differences between the two predominant dementia types. The broad range of aspects cover 1) the morphology and morphobiology of brain tissue during aging and under the two pathological condi- tions, 2) the neuropathochemistry of post mortem brain tissue of patients as well as brain tissue from experimental animals, 3) CSF changes during aging and in dementia states and 4) clinical research, mainly using brain imaging tech- niques to differentiate between dementia types and to find a basis for rational therapeutic approaches.

• Alzheimer
• Alzheimersche Krankheit
• Demenz
• Gehirn
• Gehirndurchblutung
• Leistungsminderung des Gehirns
• dementia

• Neurologische Universitätsklinik, Bonn 1, Germany

  Alexander Hartmann

• Physiologisches Institut der Universität, Heidelberg, Germany

  Wolfgang Kuschinsky

• Abt. für Pathochemie und Allg. Neurochemie, Pathologisches Institut der Universität, Heidelberg, Germany

  Siegfried Hoyer

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