Mechanisms in B-Cell Neoplasia 1990

1. Front Matter

   Pages I-XIX

   PDF

2. IL-6 in Multiple Myeloma

   1. Front Matter

      Pages 1-1

      PDF

   2. IL-6 as a Growth Factor for Human Multiple Myeloma Cells - A Short Overview

      • K. Nilsson, H. Jernberg, M. Pettersson

      Pages 3-12

   3. Interleukin 6 (IL-6) and Its Receptor (IL-6R) in Myeloma/Plasmacytoma

      • S. Suematsu, M. Hibi, T. Sugita, M. Saito, M. Murakami, T. Matsusaka et al.

      Pages 13-22

   4. Interleukin-6 is a Major Myeloma Cell Growth Factor In Vitro and In Vivo Especially in Patients with Terminal Disease

      • B. Klein, X. G. Zhang, M. Jourdan, M. Portier, R. Bataille

      Pages 23-31

   5. Macrophages as an Important Source of Paracrine IL6 in Myeloma Bone Marrow

      • Brian G. M. Durie, Elizabeth E. Vela, Yvette Frutiger

      Pages 33-36

   6. Retroviral-Mediated Transfer of Interleukin-6 Into Hematopoietic Cells of Mice Results in a Syndrome Resembling Castleman’s Disease

      • S. J. Brandt, D. M. Bodine, C. E. Dunbar, A. W. Nienhuis

      Pages 37-41

   7. A Monoclonal Antibody Specific for the Murine IL-6-Receptor Inhibits the Growth of a Mouse Plasmacytoma In Vivo

      • P. G. Coulie, A. Vink, J. Van Snick

      Pages 43-46

   8. Production of IL-2 in CD25 Positive Malignant Lymphomas

      • D. Emilie, M. Peuchmaur, P. Galanaud

      Pages 47-49

   9. IL-6 Induces Hybridoma Cell Growth Through a Novel Signalling Pathway

      • Koichi Nakajima, Randolph Wall

      Pages 51-61

   10. Selective Killing of IL6 Receptor Bearing Myeloma Cells Using Recombinant IL6-Pseudomonas Toxin

       • Clay B. Siegall, David J. FitzGerald, Ira Pastan

       Pages 63-69

   11. In Vitro Culture of a Primary Plasmacytoma that has Retained Its Dependence on Pristane Conditioned Microenvironment for Growth

       • A. Degrassi, D. M. Hilbert, A. O. Anderson, M. Potter, H. G. Coon

       Pages 71-74

3. Experimental Plasmacytomas and B-Cell Tumors

   1. Front Matter

      Pages 75-75

      PDF

   2. Modulation of Growth and Differentiation of Murine Myeloma Cells by Immunoglobulin Binding Factors

      • Richard G. Hoover, Sheryl Roman, Jonni S. Moore, Christine Darby, Susan Müller

      Pages 77-85

   3. A New Cell Adhesion Mechanism Involving Hyaluronate and CD44

      • K. Miyake, P. W. Kincade

      Pages 87-90

   4. The Activity of an ABL-MYC Retrovirus in Fibroblast Cell Lines and in Lymphocytes

      • David Largaespada, Donal Kaehler, Evi Weissinger, Harold Mischak, Fred Mushinski, Rex Risser

      Pages 91-96

   5. Plasmacytoma Induction in BALB/c6;15 → DBA/2 Chimeras

      • S. Silva, H. Sugiyama, M. Babonits, F. Wiener, G. Klein

      Pages 97-105

   6. Mouse Plasmacytoma Associated (MPC) T(15;16) Translocation Occurs Repeatedly in New MPC Induction System

      • F. Wiener, S. Silva, H. Sugiyama, M. Babonits, H. Axelson, P. Chinmay et al.

      Pages 107-119

   7. A Retrovirus Expressing v-abl and c-myc Induces Plasmacytomas in 100% of Adult Pristane-Primed BALB/c Mice

      • E. M. Weissinger, D. Largaespada, S. J. Smith-Gill, R. Risser, J. F. Mushinski, H. Mischak

      Pages 121-127

   8. Role of raf-1 Protein Kinase in IL-3 and GM-CSF-Mediated Signal Transduction

      • U. R. Rapp, J. Troppmair, M. Carroll, S. May

      Pages 129-139

The eighth workshop in this series on Mechanisms in B-Cell Neoplasia 1990 was held in Wilson Hall at the National Institutes of Health, Bethesda, Maryland on March 28-30. Five major topics formed the basis for the discussions: 1) progress in experimental models of B-cell tumorigenesis, 2) the role of IL-6 in plasma cell tumor formation with particular emphasis on human myeloma, 3) immortaliza­ tion and regulation of mitosis in B-cells, 4) the mYQ gene in B-cell neoplasia, and 5) the role of EBV and other oncogenes in transforma­ tion of human B-Iymphocytes. A meeting on the Epidemiology of Myeloma was held at the N. I. H. on the preceding day, and many of those interested in the clinical aspects of myeloma were also participants at the workshop. Experimental Models of B-Cell Tumor Development We have seen in the last eight years the steady growth of model experimental systems, many of which have been designed to be counter­ parts of the major forms of human B cell tumors, e. g. , follicular lymphomas, Burkitt's lymphomas, acute B-cell leukemia and multiple myeloma. A variety of novel ways of inducing these tumors has been described. Advantage has been taken of the "experiments in nature" to identify critical genes that playa role in tumor pathogenesis. These genes have been identified by being near to viral insertion and chromosomal translocation sites, or by having been incorporated or transduced into a defective transforming retrovirus.

• Burkitt's Lymphoma
• Lymphome
• Myelome
• Neoplasie
• Onkologie
• Tumoren
• oncology
• plasma cells
• tumorigenesis
• tumors

• Laboratory of Genetics, National Institutes of Health, National Cancer Institute, Bethesda, USA

  Michael Potter

• Basel Institute for Immunology, Basel, Switzerland

  Fritz Melchers

Policies and ethics