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Mechanisms in B-Cell Neoplasia 1990

Workshop 1990 at the National Cancer Institute National Institutes of Health Bethesda, MD, USA, March 28–30,1990

  • Book
  • © 1990

Overview

Editors:
  1. Michael Potter

    1. Laboratory of Genetics, National Institutes of Health, National Cancer Institute, Bethesda, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Fritz Melchers

    1. Basel Institute for Immunology, Basel, Switzerland

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 166)

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Table of contents (46 chapters)

  1. Front Matter

    Pages I-XIX
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  2. IL-6 in Multiple Myeloma

    1. Front Matter

      Pages 1-1
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    2. IL-6 as a Growth Factor for Human Multiple Myeloma Cells - A Short Overview

      • K. Nilsson, H. Jernberg, M. Pettersson
      Pages 3-12

    3. Interleukin 6 (IL-6) and Its Receptor (IL-6R) in Myeloma/Plasmacytoma

      • S. Suematsu, M. Hibi, T. Sugita, M. Saito, M. Murakami, T. Matsusaka et al.
      Pages 13-22

    4. Interleukin-6 is a Major Myeloma Cell Growth Factor In Vitro and In Vivo Especially in Patients with Terminal Disease

      • B. Klein, X. G. Zhang, M. Jourdan, M. Portier, R. Bataille
      Pages 23-31

    5. Macrophages as an Important Source of Paracrine IL6 in Myeloma Bone Marrow

      • Brian G. M. Durie, Elizabeth E. Vela, Yvette Frutiger
      Pages 33-36

    6. Retroviral-Mediated Transfer of Interleukin-6 Into Hematopoietic Cells of Mice Results in a Syndrome Resembling Castleman’s Disease

      • S. J. Brandt, D. M. Bodine, C. E. Dunbar, A. W. Nienhuis
      Pages 37-41

    7. A Monoclonal Antibody Specific for the Murine IL-6-Receptor Inhibits the Growth of a Mouse Plasmacytoma In Vivo

      • P. G. Coulie, A. Vink, J. Van Snick
      Pages 43-46

    8. Production of IL-2 in CD25 Positive Malignant Lymphomas

      • D. Emilie, M. Peuchmaur, P. Galanaud
      Pages 47-49

    9. IL-6 Induces Hybridoma Cell Growth Through a Novel Signalling Pathway

      • Koichi Nakajima, Randolph Wall
      Pages 51-61

    10. Selective Killing of IL6 Receptor Bearing Myeloma Cells Using Recombinant IL6-Pseudomonas Toxin

      • Clay B. Siegall, David J. FitzGerald, Ira Pastan
      Pages 63-69

    11. In Vitro Culture of a Primary Plasmacytoma that has Retained Its Dependence on Pristane Conditioned Microenvironment for Growth

      • A. Degrassi, D. M. Hilbert, A. O. Anderson, M. Potter, H. G. Coon
      Pages 71-74

  3. Experimental Plasmacytomas and B-Cell Tumors

    1. Front Matter

      Pages 75-75
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    2. Modulation of Growth and Differentiation of Murine Myeloma Cells by Immunoglobulin Binding Factors

      • Richard G. Hoover, Sheryl Roman, Jonni S. Moore, Christine Darby, Susan Müller
      Pages 77-85

    3. A New Cell Adhesion Mechanism Involving Hyaluronate and CD44

      • K. Miyake, P. W. Kincade
      Pages 87-90

    4. The Activity of an ABL-MYC Retrovirus in Fibroblast Cell Lines and in Lymphocytes

      • David Largaespada, Donal Kaehler, Evi Weissinger, Harold Mischak, Fred Mushinski, Rex Risser
      Pages 91-96

    5. Plasmacytoma Induction in BALB/c6;15 → DBA/2 Chimeras

      • S. Silva, H. Sugiyama, M. Babonits, F. Wiener, G. Klein
      Pages 97-105

    6. Mouse Plasmacytoma Associated (MPC) T(15;16) Translocation Occurs Repeatedly in New MPC Induction System

      • F. Wiener, S. Silva, H. Sugiyama, M. Babonits, H. Axelson, P. Chinmay et al.
      Pages 107-119

    7. A Retrovirus Expressing v-abl and c-myc Induces Plasmacytomas in 100% of Adult Pristane-Primed BALB/c Mice

      • E. M. Weissinger, D. Largaespada, S. J. Smith-Gill, R. Risser, J. F. Mushinski, H. Mischak
      Pages 121-127

    8. Role of raf-1 Protein Kinase in IL-3 and GM-CSF-Mediated Signal Transduction

      • U. R. Rapp, J. Troppmair, M. Carroll, S. May
      Pages 129-139
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Keywords

About this book

The eighth workshop in this series on Mechanisms in B-Cell Neoplasia 1990 was held in Wilson Hall at the National Institutes of Health, Bethesda, Maryland on March 28-30. Five major topics formed the basis for the discussions: 1) progress in experimental models of B-cell tumorigenesis, 2) the role of IL-6 in plasma cell tumor formation with particular emphasis on human myeloma, 3) immortaliza­ tion and regulation of mitosis in B-cells, 4) the mYQ gene in B-cell neoplasia, and 5) the role of EBV and other oncogenes in transforma­ tion of human B-Iymphocytes. A meeting on the Epidemiology of Myeloma was held at the N. I. H. on the preceding day, and many of those interested in the clinical aspects of myeloma were also participants at the workshop. Experimental Models of B-Cell Tumor Development We have seen in the last eight years the steady growth of model experimental systems, many of which have been designed to be counter­ parts of the major forms of human B cell tumors, e. g. , follicular lymphomas, Burkitt's lymphomas, acute B-cell leukemia and multiple myeloma. A variety of novel ways of inducing these tumors has been described. Advantage has been taken of the "experiments in nature" to identify critical genes that playa role in tumor pathogenesis. These genes have been identified by being near to viral insertion and chromosomal translocation sites, or by having been incorporated or transduced into a defective transforming retrovirus.

Editors and Affiliations

  • Laboratory of Genetics, National Institutes of Health, National Cancer Institute, Bethesda, USA

    Michael Potter

  • Basel Institute for Immunology, Basel, Switzerland

    Fritz Melchers

Bibliographic Information

  • Book Title: Mechanisms in B-Cell Neoplasia 1990

  • Book Subtitle: Workshop 1990 at the National Cancer Institute National Institutes of Health Bethesda, MD, USA, March 28–30,1990

  • Editors: Michael Potter, Fritz Melchers

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-75889-8

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1990

  • Softcover ISBN: 978-3-642-75891-1Published: 19 January 2012

  • eBook ISBN: 978-3-642-75889-8Published: 12 March 2013

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: XIX, 380

  • Topics: Allergology, Immunology, Oncology, Medical Microbiology, Virology

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