The Endothelins

1. Front Matter

   Pages I-XIII

   PDF

2. The Discovery and General Properties of the Endothelins

   • Winifred G. Nayler

   Pages 1-8

3. The Chemistry of the Endothelins

   • Winifred G. Nayler

   Pages 10-19

4. The Biosynthesis of the Endothelins

   • Winifred G. Nayler

   Pages 21-29

5. Other Chemically-Related Toxins

   • Winifred G. Nayler

   Pages 31-37

6. The Contractile Effect of Endothelin-1

   • Winifred G. Nayler

   Pages 39-48

7. The Biochemical Events Involved in the Contractile and Positive Inotropic Activity of Endothelin-1

   • Winifred G. Nayler

   Pages 49-62

8. Endothelin Receptors: Their Distribution and Properties

   • Winifred G. Nayler

   Pages 63-74

9. Metabolism and Clearance of the Endothelins

   • Winifred G. Nayler

   Pages 75-78

10. Plasma, Tissue and Urine Endothelin-1

    • Winifred G. Nayler

    Pages 80-89

11. Effect of Various Pathological Conditions on Plasma Endothelin

    • Winifred G. Nayler

    Pages 90-97

12. Endothelin and the Kidney

    • Winifred G. Nayler

    Pages 98-106

13. Endothelin and the Brain

    • Winifred G. Nayler

    Pages 107-115

14. Endothelin and the Coronary Circulation

    • Winifred G. Nayler

    Pages 116-127

15. Endothelin-1 and the Heart

    • Winifred G. Nayler

    Pages 128-138

16. Endothelin, Cell Proliferation and Atherosclerosis

    • Winifred G. Nayler

    Pages 139-147

17. The Constrictor Effect of the Endothelins on Bronchiolar and Tracheal Smooth Muscle

    • Winifred G. Nayler

    Pages 148-153

18. Endothelin and Hypertension

    • Winifred G. Nayler

    Pages 154-159

19. The Endothelins and Platelet Aggregation

    • Winifred G. Nayler

    Pages 160-162

20. Do the Endothelins have a Future?

    • Winifred G. Nayler

    Pages 163-163

"What we call the beginning is often the end, and to make an end is to make a beginning. The end is where we start from." T. S. ELIOT, "Geroniton" The discovery of endothelin-l was both an end and a beginning. It is an end because this discovery has started a plethora of investigations as to endothe1in's sites of production, mode of action, it's normal and abnormal physiological role and its involvement in a variety of pathological conditions ranging from renal failure to myocardial infarction, cardiac hypertrophy, hyperten­ sion, cyclosporine induced toxicity, mental depression, renal failure, stress related illness, and even stroke and sudden death. It is a beginning because no one can foresee where the investigations will ultimately lead, or how they will end. The discovery of the endothelins was a very recent event and soon specialist books will start to appear dealing in detail with different aspects of their chemistry, physiological role and pathological importance. The present book is intended to act as a guide and primer for those who are becoming intrigued by the many endothelin­ related articles which are now appearing in the journals but who as yet have not had the time or opportunity to be caught up in the web of enthusiasm and excitement which is motivating those more directly involved in the field of research.

• Calcium
• artery
• atherosclerosis
• chemistry
• circulation
• endothelium
• heart
• heart disease
• hypertension
• kidney
• metabolism
• platelet
• receptor
• synthesis
• tissue

• Department of Medicine Austin and Repatriation Hospital, The University of Melbourne, Heidelberg, Australia

  Winifred G. Nayler

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