Targeted Drug Delivery

1. Front Matter

   Pages I-XIV

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2. A New Perspective for Drug Delivery Research

   • R. L. Juliano

   Pages 1-9

3. Internalization and Sorting of Macromolecules: Endocytosis

   • T. E. McGraw, F. R. Maxfield

   Pages 11-41

4. Transport of Macromolecules Across the Capillary Endothelium

   • K. L. Audus, R. T. Borchardt

   Pages 43-70

5. Pharmacokinetics of Drug Targeting: Specific Implications for Targeting via Prodrugs

   • V. J. Stella, A. S. Kearney

   Pages 71-103

6. Soluble Polymers as Targetable Drug Carriers

   • N. L. Krinick, J. Kopeček

   Pages 105-179

7. Systemic Delivery of Pharmacologically Active Molecules Across the Skin

   • Y. W. Chien

   Pages 181-230

8. Chemical Delivery Systems

   • N. Bodor, M. E. Brewster

   Pages 231-284

9. In Vivo Behavior of Liposomes: Interactions with the Mononuclear Phagocyte System and Implications for Drug Targeting

   • G. L. Scherphof

   Pages 285-327

10. Antisense Oligonucleotides as Pharmacological Modulators of Gene Expression

    • G. Degols, J.-P. Leonetti, B. Lebleu

    Pages 329-354

11. Back Matter

    Pages 355-366

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The chapters in this volume describe a powerful emerging approach for the therapy of disease. Targeted drug delivery, that is control of the kinetic behavior, tissue distribution, and subcellular localization of pharmaco­ logically active agents, offers an important means for improving the efficacy of a wide variety of drug therapies. This is particularly true for therapeutic approaches based on newer agents which are the products of recombinant DNA research. These agents, be they peptides, proteins, or oligonucleotides, tend to be larger, more complex, and less stable than traditional drugs. Thus they stand to benefit most from drug delivery systems which can protect them from premature degradation and which can carry them to critical target sites in the body. This volume examines several important aspects of the current state of drug delivery research; it also attempts to project future directions for this field. Successful approaches to drug targeting are based, first of all, on a sophisticated understanding of the biological barriers encountered by the drug-carrier complex as it moves from the portal of administration to the ultimate target site. A second aspect of successful drug delivery is appro­ priate matching of the disease entity with the pharmacologically active substance and with the delivery system. Thus it is important to be aware of the variety of delivery technologies which currently exist and to be sensitive to their strengths and limitations.

• Arzneitherapie
• Nucleotide
• biology
• cell
• chemistry
• drug
• drug delivery
• gene expression
• kinetics
• molecular biology
• pharmacokinetics
• protein
• protein engineering
• research
• toxicity

• Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, USA

  Rudolph L. Juliano

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