Pharmacology of Peptic Ulcer Disease

1. Front Matter

   Pages I-XXII

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2. Pharmacology of the Parietal Cell

   • G. Sachs, P. N. Maton, B. Wallmark

   Pages 1-35

3. Epidermal Growth Factor

   • R. V. Nardi, A. Guglietta, I. Parikh

   Pages 37-54

4. Gastrin and other Peptide Hormones

   • J. Van Dam, M. M. Wolfe

   Pages 55-88

5. The Role of Essential Fatty Acids in Gastric and Duodenal Protection and Ulcer Therapy

   • D. Hollander, A. Tarnawski

   Pages 89-105

6. Helicobacter pylori

   • G. M. A. Börsch, D. Y. Graham

   Pages 107-147

7. Development of a New Gastric Antisecretory Drug for Clinical Use

   • C. W. Howden, R. H. Hunt

   Pages 149-158

8. Therapeutic use of Omeprazole in Man: Pharmacology, Efficacy, Toxicity, and Comparison with H2 Receptor Antagonists

   • P. N. Maton, G. Sachs, B. Wallmark

   Pages 159-187

9. Hypothesis of Peptic Ulcer: A Modern Classification of a Multifactorial Disease

   • S. H. Caldwell, R. W. McCallum

   Pages 189-227

10. Nonulcer Dyspepsia

    • D. A. Johnson

    Pages 229-261

11. The Natural History of Duodenal Ulcer Disease: Has it been Altered by Drug Therapy?

    • J. H. Lewis

    Pages 263-300

12. Refractory Duodenal Ulcer

    • J. W. Rademaker, R. H. Hunt

    Pages 301-323

13. Idiopathic Gastric Acid Hypersecretion

    • M. J. Collen

    Pages 325-348

14. Zollinger-Ellison Syndrome: Advances in Diagnosis and Management

    • L. S. Miller, J. D. Gardner, J. Doppman, R. T. Jensen

    Pages 349-400

15. The Pathophysiology and Treatment of Gastroesophageal Reflux Disease

    • S. B. Benjamin

    Pages 401-416

16. Endoscopy in the Evaluation and Treatment of Acid-Peptic Disease

    • P. N. Yakshe, E. L. Cattau

    Pages 417-444

17. Videoendoscopy and Digital Imaging

    • A. M. Rosen, D. E. Fleischer

    Pages 445-461

18. Back Matter

    Pages 463-464

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In this book the pathophysiology, diagnosis, and therapy of most aspects of peptic ulcer disease are examined in detail. Covered are the pharmacology of the parietal cell and the latest hypotheses for the development of acid-peptic disease including epidermal growth factor, gastrin and other peptide hormones, fatty acids and prostaglandins, helicobacter pylori, and gastric acid hypersecretion including Zollinger-Ellison syndrome. The book also deals with the newer antisecretory medication such as omeprazole with a review of H2-receptor antagonists. Rounding off the subject are chapters on gastroesophageal reflux disease, upper GI endoscopy, and videoendoscopy including digital imaging. This volume addresses a wide range of physicians who are interested in all aspects of acid-peptic disease. What distinguishes this volume from others is the timely update on a number of important issues pertaining to acid-peptic disease. Not only does it review a number of topics that are of great interest at the present time, but it introduces a vast amount of new unpublished data.

• growth factor
• pathophysiology
• pharmacology
• physiology

• Division of Gastroenterology, Loma Linda University School of Medicine, Loma Linda, USA

  Martin J. Collen

• Division of Gastroenterology, Georgetown University Hospital, USA

  Stanley B. Benjamin

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