Histamine and Histamine Antagonists

1. Front Matter

   Pages I-XXVI

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2. Current Techniques of Histamine Determination

   1. Suggestions to Those Who Have Become Histaminologists at a Time of Overflooding and Biased Information

      • W. Lorenz

      Pages 1-2

   2. Bioassays

      • P. F. Mannaioni

      Pages 3-8

   3. Fluorometric Assays

      • W. Lorenz, E. Neugebauer

      Pages 9-30

   4. Automated Fluorometric Assays

      • M. Ennis

      Pages 31-38

   5. Radioenzymatic Assays in Biological Fluids

      • M. A. Beaven

      Pages 39-48

   6. Determination by High-Performance Liquid Chromatography

      • G. Granerus

      Pages 49-58

   7. Determination in Biological Samples by Gas Chromatography-Mass Spectrometry

      • J. J. Keyzer, E. Oosting

      Pages 59-65

   8. Immunologic Methods

      • P. T. McBride, M. A. Kaliner

      Pages 67-75

   9. Measurement of Histamine Metabolites

      • J. P. Green, G. D. Prell

      Pages 77-79

   10. Munich Consensus Development Conference on Histamine Determination

       • W. Lorenz, E. Neugebauer, B. Uvnäs, M. A. Beaven, M. Ennis, G. Granerus et al.

       Pages 81-92

3. Heterogeneity of Mast Cells

   1. Heterogeneity of Mast Cells

      • K. E. Barrett, F. L. Pearce

      Pages 93-117

4. Control of the Exocytotic Mechanism in Rat Mast Cells

   1. Control of the Exocytotic Mechanism in Rat Mast Cells

      • B. D. Gomperts

      Pages 119-144

5. Formation of Histamine: Histidine Decarboxylase

   1. Formation of Histamine: Histidine Decarboxylase

      • T. Watanabe, Y. Taguchi, K. Maeyama, H. Wada

      Pages 145-163

6. Catabolism of Histamine

   1. Catabolism of Histamine

      • C. Maslinski, W. A. Fogel

      Pages 165-189

7. Histamine Receptors in Brain

   1. Histamine Receptors in Brain

      • J.-C. Schwartz, J.-M. Arrang, M.-L. Bouthenet, M. Garbarg, H. Pollard, M. Ruat

      Pages 191-242

8. Structure and Functions of the Histaminergic Neurone System

   1. Structure and Functions of the Histaminergic Neurone System

      • A. Yamatodani, N. Inagaki, P. Panula, N. Itowi, T. Watanabe, H. Wada

      Pages 243-283

9. Histamine H2 Receptors and Lung Function

   1. Histamine H2 Receptors and Lung Function

      • J. C. Foreman

      Pages 285-304

10. Histamine and the Parietal Cell

    1. Histamine and the Parietal Cell

       • K. J. Öbrink

       Pages 305-324

11. Do Histamine-Storing Cells in the Gastric Mucosa Mediate the Acid-Stimulating Action of Gastrin?

    1. Do Histamine-Storing Cells in the Gastric Mucosa Mediate the Acid-Stimulating Action of Gastrin?

       • R. Håkanson, F. Sundler

       Pages 325-346

Together with the two previous volumes of the Handbook of Experimental Pharmacology on histamine and antihistamines the present publication yields a picture of a still rapidly developing field of research. New techniques and new experimental approaches have brought us new knowledge and deeper insight into the biomedical significance of histamine, even if many questions remain to be answered about the functional and medical implications of this old biogenic amine. The present volume covers the progress in histamine research during the past two decades. A significant chapter concerns techniques for histamine determination. As the result of a consensus meeting in Munich in December 1988, a panel of eminent specialists arrived at common recommendations as to the usefulness of the available histamine assays for the most common experimental biomedical conditions. The heterogeneity of mast cells, with great differences in their reactivity to various stimuli, has become apparent, not only among species but also among the tissues of a species. New informa­ tion is presented about the mechanism of exocytosis. The old questions about the role of histamine in the mechanism of gastric secretion and in cardio­ vascular and respiratory functions have been studied with new techniques, and the role of HI and H2 receptors discussed. New observations have been made on the occurrence and possible functions of histaminergic neurons and histamine receptors in CNS where a new type of receptor, the H , seems to 3 be widely represented.

• Allergie
• Antagonist
• Histamine
• Mastzelle
• research

• Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden

  Börje Uvnäs

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