Advances in Nitrate Therapy

1. Front Matter

   Pages I-VI

   PDF

2. Introduction and Mechanism

   1. Front Matter

      Pages 1-1

      PDF

   2. Introduction

      • Adam Schneeweiss, Marija Weiss

      Pages 3-5

   3. The Mechanism of Action of Nitrates at the Cellular Level

      • Adam Schneeweiss, Marija Weiss

      Pages 6-8

3. Indications

   1. Front Matter

      Pages 9-9

      PDF

   2. Stable Angina Pectoris

      • Adam Schneeweiss, Marija Weiss

      Pages 11-13

   3. The Mechanism of Action of Nitrates in Angina Pectoris

      • Adam Schneeweiss, Marija Weiss

      Pages 14-23

   4. Nitrates Compared and Combined with Other Antianginal Drugs

      • Adam Schneeweiss, Marija Weiss

      Pages 24-37

   5. Unstable Angina Pectoris

      • Adam Schneeweiss, Marija Weiss

      Pages 38-42

   6. Long-Term Use of Nitrates in Angina Pectoris

      • Adam Schneeweiss, Marija Weiss

      Pages 43-52

   7. Silent Ischemia

      • Adam Schneeweiss, Marija Weiss

      Pages 53-54

   8. Acute Myocardial Infarction

      • Adam Schneeweiss, Marija Weiss

      Pages 55-63

   9. Congestive Heart Failure

      • Adam Schneeweiss, Marija Weiss

      Pages 64-69

   10. Congestive Heart Failure and Valvular Diseases

       • Adam Schneeweiss, Marija Weiss

       Pages 70-72

   11. Long-Term Nitrate Therapy in Congestive Heart Failure

       • Adam Schneeweiss, Marija Weiss

       Pages 73-76

   12. Nitrates Combined and Compared with Other Drugs in Congestive Heart Failure

       • Adam Schneeweiss, Marija Weiss

       Pages 77-83

   13. Systemic Hypertension, Arrhythmias and Cardiac Surgery

       • Adam Schneeweiss, Marija Weiss

       Pages 84-87

   14. Pulmonary, Abdominal, and Peripheral Vascular Effects

       • Adam Schneeweiss, Marija Weiss

       Pages 88-91

   15. Non-Cardiovascular Indications for Nitrates

       • Adam Schneeweiss, Marija Weiss

       Pages 92-93

   16. Nitrates in Children and the Elderly

       • Adam Schneeweiss, Marija Weiss

       Pages 94-98

Nitrates have been for many years the cornerstone of cardiovascular therapy for various indications. Not only have nitrates stood the test of time for treatment of chronic stable angina pectoris, but the indications for them have markedly ex­ panded. They now include all forms of angina pectoris and myocardial ischemia, congestive heart failure and hypertensive emergencies. The beneficial effects of nitrates in all these conditions result from their vasodilatory properties, but it is still unclear whether the central or peripheral effects predominate in the thera­ peutic mechanism. Recently nitrates have been shown to fulfill the most important requirement for each and every drug - to reduce mortality. A large scale study revealed that isosorbide dinitrate, combined with hydralazine, reduced long-term mortality by 28% in patients with congestive heart failure. This finding will certainly stimulate research on nitrates, and it might be expected that interest in these drugs will markedly increase. The primarily used nitrates in clinical practice are nitroglycerin and the com­ plex organic nitrates, mainly isosorbide dinitrate. The organic mononitrates are now under clinical investigation, and isosorbide-5-mononitrate (IS-5-MN) appears to be especially promising.

• Bluthochdruck
• Medikament
• Nitrate
• angina pectoris
• arrhythmia
• cardiovascular
• congenital heart disease
• drug
• drugs
• heart
• heart failure
• hypertension
• medikamentöse Behandlung
• myocardial infarction
• pharmacology

• Tel Aviv, Israel

  Adam Schneeweiss

• Köln 71, Germany

  Marija Weiss

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