Peripheral Blood Stem Cell Autografts

1. Front Matter

   Pages I-XX

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2. Introduction

   1. Front Matter

      Pages 1-1

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   2. Peripheral Blood Stem Cells: 1909 to the Nineties

      • D. M. McCarthy

      Pages 3-15

3. Biological Background

   1. Front Matter

      Pages 17-17

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   2. Transplants of Blood-Derived Hematopoietic Cells

      • R. P. Gale, A. Butturini, P. R. Henon

      Pages 19-25

   3. Biology of Haematopoietic Stem Cells

      • M. Y. Gordon

      Pages 26-34

   4. Stroma and Hematopoiesis

      • P. Charbord

      Pages 35-46

   5. Mobilization of Stem Cells and Progenitors After Thiamphenicol-Induced Hematopoietic Stress

      • H. Goris, B. Bungart, M. Loeffler, B. Dontje, W. Nijhof

      Pages 47-57

   6. Stimulation of Granulocyte Macrophage Progenitors via Monocyte/Macrophage Activation: A Fundamental Regulatory Pathway of Terminal Differentiation

      • E. Wunder

      Pages 58-66

   7. The Use of Long-Term Culture Techniques to Study Peripheral Blood Stem Cells Before and After Autologous Transplantation

      • A. Rice, C. Foures, P. Bernard, G. Marit, P. Cony-Makhoul, E. Bascans et al.

      Pages 67-72

   8. Peripheral Blood Stem Cell Transplantation: Predictions from Studies in the Mouse

      • S. Neben, K. Chayt-Marcus, P. Mauch

      Pages 73-81

   9. Production of Hematopoietic and Immune System Growth Factors After Marrow Transplantation and Their Use in Enhancing Haematopoietic and Immune Reconstitution

      • K. Atkinson

      Pages 82-88

   10. Ex Vivo and In Vivo Cytokine Studies in Irradiated Animals

       • B. R. Blazar, D. Vallera

       Pages 89-95

   11. Theoretical and Practical Considerations on the Use of Recombinant Human GM-CSF in Transplantation

       • T. C. Jones

       Pages 96-104

4. Methods

   1. Front Matter

      Pages 105-105

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   2. Identification of CD34-Positive Cells by Multiparameter Flow Cytometry

      • H. Sovalat, S. Serke

      Pages 107-127

   3. Short Term Colony Assay for CFU-GM

      • E. Wunder

      Pages 128-131

   4. Stem Cell Mobilization by Myelosuppressive Chemotherapy

      • L. B. To, C. A. Juttner

      Pages 132-144

   5. Clinical Usefulness and Optimal Harvesting of Peripheral Blood Stem Cells Mobilized by High Dose Cyclophosphamide and Recombinant Human GM-CSF

      • A. M. Gianni, M. Bregni, S. Siena, C. Tarella, D. Caracciolo, F. Ravagnani et al.

      Pages 145-154

   6. Mobilization of Blood Stem Cells with Recombinant Human (rh)G-CSF in Patients with Hematological Malignancies and Solid Tumors

      • R. Haas, S. Hohaus, R. Ehrhardt, H. Goldschmidt, B. Witt, W. Hunstein

      Pages 155-167

The monograph edited by Drs. Wunder and Henon on "Peripheral Blood Stem Cell Autogtafts" is extremely useful as well as timely. It covers the "state of the arts" with respect to the use of hemopoietic stem cells collected from the peripheral blood for the reconstitution of hematopoiesis after myeloablative therapy. If is is accepted that hematopoietic function in the mammalian organism is the result of stem cell seeding of an appropriate stromal matrix, then the use of blood derived stem cells for hematopoietic reconstitution represents the "physiological form" of the (re)­ establishment of a hematopoietic bone marrow. All observations to date are compatible with the assumption that stem cells migrate via the blood stream from extraembryonic hematopoietic tissue to the fetal liver to establish there a first intraembryonic site of blood cell formation and especially of stem cell replication and proliferation. This fetal liver tissue appears then to be the major source for the seeding offetal bone marrow stroma as it develops sequentially in all the bones of the skeleton - in other words during most of the entire embryonic development. There is a very high concentration of stem cells in the blood of the embryo (more than 20000 CFU-GM per ml in the 22nd week) and the stem cells in cord blood seem to be the "tail end" of a dramatic "stem cell traffic" in the embryo to establish the hemopoietic as well as lymphopoietic tissue.

• Autotransplantation
• Peripheral Stem Cells
• Stammzellen
• Stammzellenleukämie
• Stem Cell Mobilization
• autologe Knochenmarktransplantation
• blood
• bone marrow
• chemotherapy
• hematopoietic stem cell
• hematopoietic stem cell transplantation
• leukemia
• stem cell transplantation
• stem cells
• transplantation

• Service d’Hématologie et Institut de Recherche en Hématologie, Transfusion Hospital du Hasenrain, Mulhouse Cedex, France

  Eckart W. Wunder, Philippe R. Henon

Policies and ethics