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Viral Expression Vectors

  • Book
  • © 1992

Overview

Editors:
  1. Nicholas Muzyczka

    1. Department of Microbiology School of Medicine, State University of New York at Stony Brook, Stony Brook, USA

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Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 158)

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Table of contents (6 chapters)

  1. Front Matter

    Pages i-ix
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  2. Retroviral Vectors

    • A. D. Miller
    Pages 1-24

  3. Poxvirus Expression Vectors

    • B. Moss
    Pages 25-38

  4. Expression of Heterologous Sequences in Adenoviral Vectors

    • K. L. Berkner
    Pages 39-66

  5. Epstein-Barr Virus Based Expression Vectors

    • R. F. Margolskee
    Pages 67-95

  6. Use of Adeno-Associated Virus as a General Transduction Vector for Mammalian Cells

    • N. Muzyczka
    Pages 97-129

  7. The Baculovirus-Infected Insect Cell as a Eukaryotic Gene Expression System

    • M. J. Fraser
    Pages 131-172

  8. Back Matter

    Pages 173-178
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Keywords

About this book

In the past ten years there has been enormous progress in the development of eukaryotic viral vectors. In general, these vectors have been developed for one of three reasons: to achieve high levels of expression of a particular gene product (poxvirus, baculovirus, and adenovirus), to clone eukaryotic genes in combination with functional assays (Epstein-Barr virus), of for use as delivery vehicles for the stable introduction of foreign genes into mammalian cells (retroviruses, Epstein-Barr virus, and adeno-associated virus). Each vector has its strengths and weaknesses that are rooted in the sometimes bewildering stra­ tegies that the parent viruses use for propagation. No one of these vectors is appropriate for all of the problems that a mole­ cular biology laboratory is likely to encounter, and few of us are knowledgeable in the molecular virology of all of these viruses. This volume represents an attempt by the authors to assem­ ble a review of these vectors in one place and in a form useful to laboratories that do not necessarily have experience with eukaryotic viruses. Clearly, any virus can be modified to serve as a vector for some purposes, and it was not possible to include a description of all of these. In addition, one eukaryotic vector, SV40 (the first one developed), has been reviewed so widely that we saw no reason to include it here.

Editors and Affiliations

  • Department of Microbiology School of Medicine, State University of New York at Stony Brook, Stony Brook, USA

    Nicholas Muzyczka

Bibliographic Information

  • Book Title: Viral Expression Vectors

  • Editors: Nicholas Muzyczka

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-75608-5

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1992

  • Softcover ISBN: 978-3-642-75610-8Published: 13 December 2011

  • eBook ISBN: 978-3-642-75608-5Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: IX, 176

  • Number of Illustrations: 5 b/w illustrations

  • Topics: Virology, Cell Biology, Biochemistry, general

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