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Cytokines in Hemopoiesis, Oncology, and AIDS

  • Conference proceedings
  • © 1990

Overview

Editors:
  1. Mathias Freund

    1. Abt. Hämatologie und Onkologie, Medizinische Hochschule Hannover, Hannover 61, Germany

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  2. Hartmut Link

    1. Abt. Hämatologie und Onkologie, Medizinische Hochschule Hannover, Hannover 61, Germany

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  3. Karl Welte

    1. Abt. Pädiatrische Hämatologie und Onkologie, Medizinische Hochschule Hannover, Hannover 61, Germany

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Table of contents (95 papers)

  1. Front Matter

    Pages i-lvii
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  2. Overview

    1. Front Matter

      Pages 1-1
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    2. Colony Stimulating Factors:Past and Future

      • D. Metcalf
      Pages 3-7

    3. Regulation of Hematopoietic Progenitor Cell Growth by Stimulating and Suppressing Cytokines

      • H. E. Broxmeyer
      Pages 9-13

    4. Cytokine Interactions in Normal and Malignant Hematopoiesis

      • N. A. Cicco, W. Oster, A. Lindemann, R. Mertelsmann, F. Herrmann
      Pages 15-25

  3. Preclinical and In Vitro Data

    1. Front Matter

      Pages 27-27
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    2. Colony Stimulating Factors in Normal Hematopoiesis

      1. Screening the Sensitivity of Hematopoietic Progenitor Cells to Different Growth Factors. Potential Importance in Therapy Trials with Colony Stimulating Factors
        • K. Vehmeyer, T. Liersch, G. Krieger, J. H. Beyer, G. A. Nagel
        Pages 29-36
      2. Effect of Human Recombinant Interleukin-3 in Long-term Bone Marrow Culture
        • R. Haas, D. Schwarz, S. Hohaus, E. Ogniben, G. Wulf, W. Hunstein
        Pages 37-44
      3. Secretion of Colony-Stimulating Factor for Macrophages (M-CSF) and Granulocyte/Macrophages (GM-CSF) is Developmentally Regulated in Human Macrophages
        • C. Scheibenbogen, G. Zenke, B. Faggs, K. Motoyoshi, L. Kanz, H. Sawert et al.
        Pages 45-51
      4. Expression of the M-CSF/CSF-1 Gene in Normal Human Alveolar Macrophages
        • H. Kreipe, H. J. Radzun, K. Heidorn, J. Barth, M. R. Parwaresch
        Pages 53-58
      5. Surface Expression of Interleukin-2 Receptors and CD4 Molecules by Human Eosinophils is Induced by GM-CSF and IL-3
        • D. Riedel, M. Brach, R. Mertelsmann, F. Herrmann
        Pages 59-65
      6. Expression of Interleukin Receptors on Human Eosinophils, Basophils, and Mast Cells
        • P. Valent, J. Besemer, H. Stockinger, E. Liehl, P. Bettelheim
        Pages 67-71
      7. Chemiluminescence of Polymorphonuclear Leukocytes in Response to Interferons
        • M. Suttorp, U. Barzantny, M. Rister
        Pages 73-80
      8. Glycolysis and Amino Acid Incorporation in IL-3-Dependent Cell Lines
        • G. Reisbach, J. Ellwart, P. Dörmer
        Pages 81-83
      9. Fibroblast Colony Stimulating Activity of GM-CSF and IL-3 in Human Bone Marrow Cell Cultures
        • P. Valent, K. Geissler, P. Kalhs, P. Kier, P. Bettelheim
        Pages 85-89
      10. Chromatin and DNA Methylation Changes of the Human Myeloperoxidase Gene During Myeloid Differentiation
        • M. Lübbert, C. W. Miller, R. Mertelsmann, F. Herrmann, H. P. Koeffler
        Pages 91-101
      11. Retroviral-Mediated Transfer of Genes Encoding for Growth Factors into Human Hematopoietic Stem Cells
        • A. A. Fauser, P. Laneuville, R. Tellier, G. Egert, G. W. Löhr
        Pages 103-106

    3. Colony Stimulating Factors in Malignant Hematopoiesis

      1. Recruitment Therapy in Acute Myeloblastic Leukemia:A Different Approach to Improved Leukemia Treatment
        • A. Tafuri, M. Andreeff
        Pages 107-113
      2. Effects of Hematopoietic Growth Factors on Myelodysplastic Syndrome Progenitors
        • X. Thomas, L. Campos, L. Vila, Z. H. Shi, D. Guyotat, D. Fiere
        Pages 115-122
      3. Combined Cytogenetic and Proliferation Studies of GM-CSF-Stimulated Bone Marrow Cells in Myelodysplasia and Acute Leukemia
        • D. Haase, C. Fonatsch
        Pages 123-128
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Keywords

About this book

The clinical and experimental effects of cytokines have been realized for a long time. The clinical effects of tumor necrosis factor were noted almost 100 years ago. The basic biological effects of interferons and the hemopoietic growth factors have been known for more than 20 years. Given the basis of modern molecular biotechniques, information concern­ ing the mediators of cellular interactions is expanding almost exponentially. New principles in the regulation of cell growth, microenvironment, immune response, and malignancy are being discoverd right now. New therapeutic options are becoming available and have, in some areas, already crossed the threshold of clinical application. However, the way forward might be more complicated than we are in a position to recognize today. Some of the first optimistic expectations have not yet been fulfilled. Nevertheless, we are experiencing a revolution in medicine. To contribute to this process and to stimulate scientific communi­ in this field, we have initiated the international symposia on cytokines cation in hemopoiesis, oncology and aids. Major contributions from the first sym­ posium are published in this book. We thank all the authors for their contri­ butions, particularly those from the Hannover Medical School, who have worked hard to realize the congress and prepare these proceedings. We also thank the pharmaceutical companies whose support made this book possible. Finally we thank Professors Deicher, Poliwoda, and Riehm, heads of the Departments of Hematology and Oncology, Immunology, and Pediatric Hematology and Oncology, respectively, who encouraged us and gave us their firm support.

Editors and Affiliations

  • Abt. Hämatologie und Onkologie, Medizinische Hochschule Hannover, Hannover 61, Germany

    Mathias Freund, Hartmut Link

  • Abt. Pädiatrische Hämatologie und Onkologie, Medizinische Hochschule Hannover, Hannover 61, Germany

    Karl Welte

Bibliographic Information

  • Book Title: Cytokines in Hemopoiesis, Oncology, and AIDS

  • Editors: Mathias Freund, Hartmut Link, Karl Welte

  • DOI: https://doi.org/10.1007/978-3-642-75510-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1990

  • Softcover ISBN: 978-3-540-52281-2Published: 30 November 1990

  • eBook ISBN: 978-3-642-75510-1Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: LVII, 762

  • Number of Illustrations: 71 b/w illustrations

  • Topics: Hematology, Pathology, Oncology, Allergology, Immunology

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