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The Role of Viruses and the Immune System in Diabetes Mellitus

Experimental Models

  • Conference proceedings
  • © 1990

Overview

Editors:
  1. Thomas Dyrberg

    1. Hagedorn Research Laboratory, Gentofte, Denmark

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Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 156)

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Table of contents (9 papers)

  1. Front Matter

    Pages I-XI
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  2. The Spontaneously Diabetic BB Rat: Sites of the Defects Leading to Autoimmunity and Diabetes Mellitus. A Review

    • J. Scott
    Pages 1-14

  3. Immune Pathogenesis of Diabetes in the Nonobese Diabetic Mouse: An Overview

    • T. Hanafusa, S. Tarui
    Pages 15-25

  4. Streptozotocin Interactions with Pancreatic β Cells and the Induction of Insulin-Dependent Diabetes

    • G. L. Wilson, E. H. Leiter
    Pages 27-54

  5. Autoantigen (64000-Mr) Expression in Coxsackievirus B4-Induced Experimental Diabetes

    • I. Gerling, N. K. Chatterjee
    Pages 55-62

  6. Effects of Rubella Virus Infection on Islet Function

    • E. J. Rayfield
    Pages 63-74

  7. Monoclonal (Auto)Antibodies in Insulin-Dependent Diabetes Mellitus

    • O. D. Madsen, G. Contreas, J. Jørgensen
    Pages 75-86

  8. The Genetics of Insulin-Dependent Diabetes in the BB Rat

    • W. Kastern, F. Lang, I. Kryspin-Sørensen
    Pages 87-102

  9. The Role of Class II Molecules in Development of Insulin-Dependent Diabetes Mellitus in Mice, Rats and Humans

    • H. Acha-Orbea, H. O. McDevitt
    Pages 103-119

  10. Major Histocompatibility Complex Molecules and the Beta Cell: Inferences from Transgenic Models

    • J. Allison, L. C. Harrison, I. L. Campbell, J. F. A. P. Miller
    Pages 121-135

  11. Back Matter

    Pages 137-142
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Keywords

About this book

Research in diabetes has accelerated in two areas, both of which are being reviewed in CTMI. The first is the use of a variety of animal models; the second is basic research in human investigation, islet cell antigens, and mapping of genes as­ sociated with susceptibility to disease. Dr. Thomas Dyrberg accepted editorial responsibility for this volume, which covers the first area. A second book, to be published later in the year, is edited by Drs. Brekkeskov and Hansen (CTMI 164, see page VI for contents). Although the contributors to both volumes represent the international scientific community, the editors are from the Hagedorn Research Laboratory in Denmark. Work at this institute and the Steno Memorial Hospital has been dedicated to research in diabetes for decades, and the insti­ tutions were appointed WHO Collaborating Centres for Re­ search and Training on the Pathogenesis of Diabetes Mellitus in 1983. It is worth noting that while addressing the hypothesis of the role of class II major histocompatibility glycoproteins in autoimmune diabetes (insulin-dependent diabetes, IDDM) a number of investigators established animal models in which class II molecules were expressed under the control of the rat insulin promoter. While generating interesting information on 100M, the finding of immunologic tolerance in such transgenic mice has attracted the attention of several basic immunologic laboratories for quite different reasons. Thus, we are reminded again of the Pasteur dictum that "chance favors the prepared mind. " Michael B. A. Oldstone, M. D.

Editors and Affiliations

  • Hagedorn Research Laboratory, Gentofte, Denmark

    Thomas Dyrberg

Bibliographic Information

  • Book Title: The Role of Viruses and the Immune System in Diabetes Mellitus

  • Book Subtitle: Experimental Models

  • Editors: Thomas Dyrberg

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-75239-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1990

  • Softcover ISBN: 978-3-642-75241-4Published: 13 December 2011

  • eBook ISBN: 978-3-642-75239-1Published: 29 June 2013

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: XI, 139

  • Number of Illustrations: 6 b/w illustrations

  • Topics: Allergology, Immunology, Virology, Endocrinology

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