Post-Transcriptional Control of Gene Expression

1. Front Matter

   Pages I-XIX

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2. mRNA Stability

   1. Ribonucleases: Diversity and Regulation

      • Murray P. Deutscher, Jiren Zhang

      Pages 1-11

   2. Degradation of puf mRNA in Rhodobacter Capsulatus and its Role in the Regulation of Gene Expression

      • Gabriele Klug, Stanley N. Cohen

      Pages 13-20

   3. Mutational Analysis of a RNase E Dependent Cleavage Site from a Bacteriophage T4 mRNA

      • C. Ehretsmann, A. J. Carpousis, H. M. Krisch

      Pages 21-30

   4. The role of a novel site-specific endoribonuclease in the regulated decay of E.coli mRNA — a model for growth-stage dependent mRNA stability in bacteria

      • A. von Gabain, D. Georgellis, U. Lundberg, Ö. Melefors, L. Melin, O. Resnekov

      Pages 31-43

   5. Regulation of mRNA Stability in Yeast

      • Allan Jacobson, Agneta H. Brown, Janet L. Donahue, David Herrick, Roy Parker, Stuart W. Peltz

      Pages 45-54

   6. Mutations Involved in mRNA Stability and in the Length of their Poly(A) Tails in the Yeast Saccharomyces cerevisiae

      • L. Minvielle-Sebastia, A. Petitjean, B. Winsor, N. Bonneaud, F. Lacroute

      Pages 55-64

   7. Rapid Degradation of the c-FOS Proto-Oncogene Transcript

      • Joel G. Belasco, Ann-Bin Shyu, Michael E. Greenberg

      Pages 65-71

   8. Post-Transcriptional Control of Gene Expression in Chloroplasts

      • David B. Stern, Chen Hsu-Ching, Cynthia C. Adams, Karen L. Kindle

      Pages 73-82

   9. Differential mRNA Stability: A Regulatory Strategy for Hsp70 Synthesis

      • Robert B. Petersen, Susan Lindquist

      Pages 83-91

3. Antisense Regulation

   1. Post-Transcriptional Control of IS10 Transposase Expression: Antisense RNA Binding and Other Conformational Changes Affecting Messenger RNA Stability and Translation

      • C. Ma, J. E. Gonzalez, C. C. Case, T. Sonnabend, J. Rayner, R. W. Simons

      Pages 93-102

   2. The Antisense Approach and Early Xenopus Development

      • A Colman, C Baker, J Shuttleworth

      Pages 103-112

4. Transcriptional (Anti-)Termination

   1. The Role of Boxa in Transcription of Ribosomal RNA Operons of Eschericha Coli: Changes in the Processivity of RNA Polymerase

      • R. J. Gaudino, E. A. Morgan

      Pages 113-123

   2. Regulation Of λ N-Gene Expression

      • Luis Kameyama, Leonor Fernandez, Gabriel Guarneros, Donald L. Court

      Pages 125-133

   3. Messenger RNA 3′ End Formation in E. Coli and S. Cerevisiae

      • T. Platt, C. A. Brennan, J. S. Butler, D. A. Campbell, P. P. Sadhale, P. Spear et al.

      Pages 135-144

5. Translational Control

   1. Culture Conditions Affect Differently the Translation of Individual Escherichia Coli mRNAs

      • N. Jacques, M. Chevrier-Miller, J. Guillerez, M. Dreyfus

      Pages 145-155

   2. Post-Transcriptional Control in E.coli: The Translation and Degradation of mRNA

      • John E. G. McCarthy, Birgit Gerstel, Karsten Hellmuth, Volker Lang, Brian Surin, Peter Ziemke

      Pages 157-168

   3. Control of Translational Initiation by mRNA Secondary Structure: A Quantitative Analysis

      • Maarten H. de Smit, Jan van Duin

      Pages 169-184

   4. The Role of Ribosomal RNA in the Control of Gene Expression

      • Matthew A. Firpo, Albert E. Dahlberg

      Pages 185-195

   5. The Phage f1 Gene VII Start Site and its Mutants Reveal that Translational Coupling can Confer Function to Inherently Inactive Initiation Sites

      • D. A. Steege, M. Ivey-Hoyle

      Pages 197-206

The last ten years have witnessed a remarkable increase in our awareness of the importance of events subsequent to transcriptional initiation in terms of the regulation and control of gene expression. In particular, the development of recombinant DNA techniques that began in the 1970s provided powerful new tools with which to study the molecular basis of control and regulation at all levels. The resulting investigations revealed a diversity of post-transcriptional mechanisms in both prokaryotes and eukaryotes. Scientists working on translation, mRNA stability, transcriptional (anti)termination or other aspects of gene expression will often have met at specialist meetings for their own research area. However, only rarely do workers in different areas of post-transcriptional control/ regulation have the opportunity to meet under one roof. We therefore thought it was time to bring together leading representatives of most of the relevant areas in a small workshop intended to encourage interaction across the usual borders of research, both in terms of the processes studied, and with respect to the evolutionary division prokaryotes/eukaryotes. Given the breadth of topics covered and the restrictions in size imposed by the NATO workshop format, it was an extraordinarily difficult task to choose the participants. However, we regarded this first attempt as an experiment on a small scale, intended to explore the possibilities of a meeting of this kind. Judging by the response of the participants during and after the workshop, the effort had been worthwhile.

• DNA
• Genaktivität
• Gene activity
• Gene regulation
• Genexpression
• Genregulation
• RNA
• Termination
• gene
• gene expression
• genes
• regulation
• transcription
• translation

• Gesellschaft für Biotechnologische Forschung mbH, Braunschweig, Germany

  John E. G. McCarthy

• Biological Laboratory, University of Kent, Canterbury, Kent, England

  Mick F. Tuite

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