Search for the Causes of Schizophrenia

1. Front Matter

   Pages I-IX

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2. Introduction

   1. Introduction

      • H. Häfner, W. F. Gattaz

      Pages 1-3

3. Epidemiology of Schizophrenia

   1. Front Matter

      Pages 5-5

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   2. Deviant Birth Season Distribution: Does it Offer a Clue to the Aetiology of Schizophrenia?

      • P. Dalén

      Pages 7-13

   3. Gender Differences in Age at Onset and Course of Schizophrenic Disorders

      • A. Riecher, K. Maurer, W. Löffler, B. Fätkenheuer, W. An Der Heiden, P. Munk-Jørgensen et al.

      Pages 14-33

   4. Early Predictors of Onset and Course of Schizophrenia and Schizophrenia Spectrum

      • J. Parnas, S. A. Mednick

      Pages 34-47

   5. Epidemiology of Schizophrenia: Discussion

      • J. Angst

      Pages 48-53

4. Determinants of Course and Outcome of Schizophrenia

   1. Front Matter

      Pages 55-55

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   2. The International Pilot Study of Schizophrenia: Five-Year Follow-Up Findings

      • J. Leff, N. Sartorius, A. Jablensky, M. Anker, A. Korten, W. Gulbinat et al.

      Pages 57-66

   3. What Is Crucial for the Long-Term Outcome of Schizophrenia?

      • E. C. Johnstone

      Pages 67-76

   4. Models for the Development of Symptomatology and Course of Schizophrenia

      • K. Maurer, H. Biehl

      Pages 77-93

   5. Interaction of Environment and Personality in the Course of Schizophrenia

      • J. Leff

      Pages 94-106

5. Genetics of Schizophrenia

   1. Front Matter

      Pages 107-107

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   2. Models of Heritability and Genetic Transmission

      • P. McGuffin

      Pages 109-125

   3. Gene-Environment Interaction in Adoptive Families

      • P. Tienari

      Pages 126-143

   4. The Reverse Genetic Approach to the Etiology of Schizophrenia

      • L. E. DeLisi, M. Lovett

      Pages 144-170

   5. Genetics of Schizophrenia: Discussion

      • P. Propping

      Pages 171-173

6. Vulnerability Models for Schizophrenia

   1. Front Matter

      Pages 175-175

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   2. Testing Vulnerability Models: Stability of Potential Vulnerability Indicators Across Clinical State

      • K. H. Nuechterlein, M. E. Dawson, J. Ventura, D. Fogelson, M. Gitlin, J. Mintz

      Pages 177-191

   3. The Contributions of Psychophysiology to Vulnerability Models

      • R. Olbrich

      Pages 192-204

H. HAFNER and W. F. GATTAZ Between 1891 and 1955, three founders of modern psychiatry, Emil Kraepelin (1856-1926), Karl Jaspers (1883-1969) and Kurt Schneider (1887-1967) lectured at the University of Heidelberg: Kraepelin for 12 years, Jaspers for over 25 years and Schneider for approximately 10 years. During this period they laid the foundations of descriptive psychopathology and modern classification and con­ tributed essentially to the development of our current thinking on schizophrenia. In 1986, on the occasion of the 600th anniversary of the University of Heidel­ berg, we held a symposium in memory of these three "giants of psychiatry" for which we chose the title "Search for the Causes of Schizophrenia". It was jointly organized by the Central Institute of Mental Health in Mannheim and the Department of Psychiatry of the University of Heidelberg. The intention was to meet one of the major challenges of current psychiatric research, namely the fact that since Kraepelin's masterly description of "Dementia praecox" (1894) and E. Bleuler's slightly different definition of schizophrenia (1911), we have made only insufficient advances in clarifying the aetiology of this frequent and still often dis­ abling mental disease.

• Syndrom
• brain
• dementia
• epidemiology
• genetics
• memory
• neuropsychology
• physiology
• psychiatry
• psychology
• psychopathology
• psychosis
• schizophrenia
• syndromes
• thinking

• Central Institute of Mental Health, Mannheim 1, Germany

  Heinz Häfner, Wagner Farid Gattaz

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