Chemical Carcinogenesis and Mutagenesis II

1. Front Matter

   Pages I-XXVI

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2. Relationships Between Mutagenesis and Carcinogenesis

   1. Front Matter

      Pages 1-1

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   2. Use of Mutations in Bacteria as Indicators of Carcinogenic Potential

      • R. D. Callander

      Pages 3-26

   3. Mammalian Cell Mutations

      • C. F. Arlett

      Pages 27-50

   4. Mechanisms of Repair in Mammalian Cells

      • M. Defais

      Pages 51-70

   5. Cancer-Prone Human Disorders with Defects in DNA Repair

      • A. R. Lehmann, S. W. Dean

      Pages 71-101

   6. DNA Repair and Carcinogenesis by Alkylating Agents

      • A. E. Pegg

      Pages 103-131

3. Modifiers of Chemical Carcinogenesis

   1. Front Matter

      Pages 133-133

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   2. Tumour Promotion: Biology and Molecular Mechanisms

      • A. W. Murray, A. M. Edwards, C. S. T. Hii

      Pages 135-157

   3. Inhibition of Chemical Carcinogenesis

      • J. DiGiovanni

      Pages 159-223

   4. Genetic Susceptibility to Chemical Carcinogens

      • D. G. Harnden

      Pages 225-248

   5. Interactive Effects Between Viruses and Chemical Carcinogens

      • A. Haugen, C. C. Harris

      Pages 249-268

4. Oncogenes in Tumor Development

   1. Front Matter

      Pages 269-269

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   2. Human Oncogenes

      • A. Hall

      Pages 271-295

   3. Recessive Oncogenes and Anti-Oncogenes

      • J. K. Cowell

      Pages 297-318

   4. The Role of Oncogene Activation in Chemical Carcinogenesis

      • C. S. Cooper

      Pages 319-352

   5. Growth Factors and Their Receptors

      • C.-H. Heldin, B. Westermark

      Pages 353-379

   6. Signal Transduction in Proliferating Normal and Transformed Cells

      • M. J. O. Wakelam

      Pages 381-401

   7. Effect of Oncogenes on Cell Differentiation

      • D. Boettiger, D. Chalmers

      Pages 403-438

5. Back Matter

   Pages 439-467

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I have been privileged to witness and participate in the great growth of knowledge on chemical carcinogenesis and mutagenesis since 1939 when I entered graduate school in biochemistry at the University of Wisconsin­ Madison. I immediately started to work with the carcinogenic aminoazo dyes un­ der the direction of Professor CARL BAUMANN. In 1942 I joined a fellow graduate student, ELIZABETH CA VERT, in marriage and we soon commenced a joyous part­ nership in research on chemical carcinogenesis at the McArdle Laboratory for Cancer Research in the University of Wisconsin Medical School in Madison. This collaboration lasted 45 years. I am very grateful that this volume is dedi­ cated to the memory of Elizabeth. The important and varied topics that are reviewed here attest to the continued growth of the fields of chemical car­ cinogenesis and mutagenesis, including their recent and fruitful union with viral oncology. I feel very optimistic about the application of knowledge in these fields to the eventual solution of numerous problems, including the detection and estimation of the risks to humans of environmental chemical carcinogens and re­ lated factors.

• Carcinom
• DNA
• Mutagene
• Onkogene Viren
• cancer
• cancer research
• carcinogenesis
• cellular differentiation
• mutagen
• mutagenesis
• oncogene
• oncogenes
• research
• tumor

• Chester Beatty Laboratories, The Institute of Cancer Research: Royal Cancer Hospital, London, Great Britain

  Colin S. Cooper, Philip L. Grover

Policies and ethics