Chemical Carcinogenesis and Mutagenesis I

1. Front Matter

   Pages I-XXVIII

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2. Theories of Carcinogenesis

   1. Front Matter

      Pages 1-1

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   2. Mechanisms of Chemical Carcinogenesis: Theoretical and Experimental Bases

      • H. C. Pitot

      Pages 3-29

3. Exposure to Chemical Carcinogens

   1. Front Matter

      Pages 31-31

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   2. Environmental Carcinogens

      • K. Hemminki

      Pages 33-61

   3. Advances in Tobacco Carcinogenesis

      • D. Hoffmann, S. S. Hecht

      Pages 63-102

   4. Occupational Carcinogens

      • C. E. Searle, O. J. Teale

      Pages 103-151

   5. Therapeutic Agents as Potential Carcinogens

      • D. B. Ludlum

      Pages 153-175

4. In Vivo and In Vitro Carcinogenesis

   1. Front Matter

      Pages 177-177

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   2. In Vivo Testing for Carcinogenicity

      • W. Lijinsky

      Pages 179-209

   3. Transformation of Cells in Culture

      • M. A. Knowles

      Pages 211-264

5. Reactions of Carcinogens with DNA

   1. Front Matter

      Pages 265-265

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   2. Metabolic Activation and DNA Adducts of Aromatic Amines and Nitroaromatic Hydrocarbons

      • F. A. Beland, F. F. Kadlubar

      Pages 267-325

   3. Polycyclic Aromatic Hydrocarbons: Metabolism, Activation and Tumour Initiation

      • M. Hall, P. L. Grover

      Pages 327-372

   4. Interactions of Fungal and Plant Toxins with DNA: Aflatoxins, Sterigmatocystin, Safrole, Cycasin, and Pyrrolizidine Alkaloids

      • J. D. Groopman, L. G. Cain

      Pages 373-407

   5. N-Nitroso Compounds

      • P. D. Lawley

      Pages 409-469

   6. Heterocyclic-Amine Mutagens/Carcinogens in Foods

      • J. S. Felton, M. G. Knize

      Pages 471-502

   7. Modern Methods of DNA Adduct Determination

      • D. H. Phillips

      Pages 503-546

   8. Biological Consequences of Reactions with DNA: Role of Specific Lesions

      • G. P. Margison, P. J. O’Connor

      Pages 547-571

6. Back Matter

   Pages 573-604

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I have been privileged to witness and participate in the great growth of knowledge on chemical carcinogenesis and mutagenesis since 1939 when I entered graduate school in biochemistry at the University of Wisconsin­ Madison. I immediately started to work with the carcinogenic aminoazo dyes un­ der the direction of Professor CARL BAUMANN. In 1942 I joined a fellow graduate student, ELIZABE1H CAVERT, in marriage and we soon commenced a joyous part­ nership in research on chemical carcinogenesis at the McArdle Laboratory for Cancer Research in the University of Wisconsin Medical School in Madison. This collaboration lasted 45 years. I am very grateful that this volume is dedi­ cated to the memory of Elizabeth. The important and varied topics that are reviewed here attest to the continued growth of the fields of chemical car­ cinogenesis and mutagenesis, including their recent and fruitful union with viral oncology. I feel very optimistic about the application of knowledge in these fields to the eventual solution of numerous problems, including the detection and estimation of the risks to humans of environmental chemical carcinogens and re­ lated factors.

• Carcinom
• DNA
• Mutagene
• Onkogene Viren
• cancer
• cancer research
• carcinogenesis
• cellular differentiation
• mutagen
• mutagenesis
• oncogene
• oncogenes
• research

• Chester Beatty Laboratories, The Institute of Cancer Research: Royal Cancer Hospital, London, Great Britain

  Colin S. Cooper, Philip L. Grover

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