High-Risk Breast Cancer

1. Front Matter

   Pages I-XIII

   PDF

2. Introduction

   1. Front Matter

      Pages 1-1

      PDF

   2. Therapeutic Highlights of High-Risk Breast Cancer: Comments Related to Surgery, Radiotherapy, and Hormonal Therapy

      • J. Ragaz, I. M. Ariel

      Pages 3-23

3. General

   1. Front Matter

      Pages 25-25

      PDF

   2. Metastasis as a Determinant of Risk in Breast Cancer

      • J. E. Price, I. J. Fidler

      Pages 27-46

   3. Comments on Clinical and Therapeutic Aspects of High-Risk Breast Cancer

      • R. D. Rubens, M. A. Chaudary

      Pages 47-70

   4. Role of Preoperative Therapy in High-Risk Breast Cancer: Review

      • J. Ragaz

      Pages 71-84

4. Surgery

   1. Front Matter

      Pages 85-85

      PDF

   2. The Role of Surgery in the Treatment of Breast Cancer: Historical Review and Current Status

      • I. M. Ariel

      Pages 87-107

   3. High-Risk Breast Cancer: Bilaterality

      • P. I. Pressman

      Pages 108-120

   4. Conservative Surgery and Radiation Therapy for Early Breast Cancer

      • I. A. Olivotto, V. E. Basco, S. M. Jackson

      Pages 121-138

5. Radiotherapy

   1. Front Matter

      Pages 139-139

      PDF

   2. The Role of Radiation Therapy in High-Risk Breast Cancer

      • J. M. Robertson, D. H. Clarke, A. Martinez

      Pages 141-159

6. Hormonal Therapy

   1. Front Matter

      Pages 161-161

      PDF

   2. The Role of Prolonged Antihormonal Treatment of Breast Cancer: A Strategy for Adjuvant Therapy

      • A. Friedl, V. C. Jordan

      Pages 163-183

   3. Adjuvant Endocrine Therapy: Its Role in Primary Breast Cancer

      • S. R. Ebbs, D. Riley, M. Baum

      Pages 184-196

7. Chemotherapy—General

   1. Front Matter

      Pages 197-197

      PDF

   2. Therapeutic Highlights of High-Risk Breast Cancer: Comments Related to Adjuvant Chemotherapy, Its Intensity, Duration, and Quality of Life

      • J. Ragaz, I. M. Ariel

      Pages 199-220

   3. Dose Intensity of Chemotherapy in High-Risk Breast Cancer

      • W. M. Hryniuk

      Pages 221-234

8. Therapy — Adjuvant

   1. Front Matter

      Pages 235-235

      PDF

The many advances in breast cancer research, as well as the large quantity of published material, make it very difficult to gain insight into the global aspects of cancer management. To follow and understand all the new developments is becoming a major challenge. For this reason, the editors decided to bring together a group of top researchers in breast cancer to provide a comprehensive, yet readable conceptual review of the state of the art of breast cancer diagnosis and therapy. The proposal to focus the review on the quantitative assessment of the risk at diagnosis, the determination of which may permit selective therapies for individual patients, was met with enthusiastic approval, resulting in the present volume with contributions by the leading investigators in the field. While the volume relating to diagnosis, published re­ cently, focused on efforts leading to refinement at diagnosis of risk criteria sensitive enough to reliably distinguish the low- and high-risk categories, the second volume, by provid­ ing a review of the main problems and results of therapy given to high-risk patients, can be considered as a continua­ tion of the first book. A refined risk assessment at diagnosis and the application of the most suitable treatments to well­ selected individuals are the most important steps towards avoiding the present worrisome reality of overtreating the low risk and undertreating the high-risk patients. The first few chapters of the present volume offer an insight into the general management of early breast cancer.

• Breast Cancer
• Brustkrebs
• Krebstherapie
• Tumor
• biopsy
• carcinoma
• diagnosis
• surgery

• Medical Oncology, British Columbia Cancer Agency, Vancouver, Canada

  Joseph Ragaz

• Foundation for Clinical Research Inc., New York, USA

  Irving M. Ariel

Policies and ethics