Biologically Active Molecules

1. Front Matter

   Pages I-VIII

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2. Some Chemical Phenomena of Mushrooms and Toadstools

   • Wolfgang Steglich

   Pages 1-8

3. β-Methoxyacrylate Antibiotics: From Biological Activity to Synthetic Analogues

   • Timm Anke, Wolfgang Steglich

   Pages 9-25

4. Lipopeptides, an Interesting Class of Microbial Secondary Metabolites

   • J. Vater

   Pages 27-38

5. FAB: Basic Concepts and Practical Considerations

   • Richard M. Caprioli

   Pages 39-58

6. Continuous-Flow Fast Atom Bombardment Mass Spectrometry

   • Richard M. Caprioli

   Pages 59-78

7. Coupling Chromatographic Techniques with FABMS for the Structural Analysis of Biological Compounds

   • Richard M. Caprioli

   Pages 79-96

8. The Application of High Mass FAB Mass Spectrometry to Molecular Biology

   • Howard R. Morris, Anne Dell, Maria Panico, Roy McDowell, Ashraf Chatterjee

   Pages 97-147

9. Identification of Active-Site in a Neurotoxic Snake Venom by Affinity Labelling and State-of-the-Art Tandem Mass Spectrometry Technology

   • Thaiya Krishnamurthy, Marguerite E. Brooks, Donald F. Hunt, Jeffrey Shabanowitz, Shuian Chen, Terry Lee

   Pages 149-160

10. Peptide Defence Systems

    • Dudley H. Williams

    Pages 161-216

11. Genetically Designed Affinity Chromatography Using a Novel Metal Chelate Absorbent

    • E. Hochuli

    Pages 217-239

12. Structure-Activity Relationship in Biomembranes Investigated by Infrared-ATR Spectroscopy

    • U. P. Fringeli

    Pages 241-252

Over the past few years there has been a remarkable and rapid development of modern analytical methods, and the fields of nuclear magnetic resonance and mass spectrometry have been no exception. In addition to being able to do "more and faster", new innovative techniques have also arisen to contribute to a growing understanding of the relationship between chemical structure and biological activity. In order to explore a few of the more interesting points of those developments and applications, a seminar "From Biological Activity to Structure" was organized from September 5-7, 1988, at Interlaken. The four invited speakers, Richard M. Caprioli, Howard R. Morris, Wolfgang Steglich and Dudley H. Williams were kind enough to attend and discuss many facets of their research, especially methodological and technical developments and their applications to specific problems. Participants were introduced to continuous flow FAB (fast atom bombardment) and its use, for example, in the real time monitoring of biochemical reactions in vitro and in vivo; the structural elucidation of secondary metabolites from fungi; the analysis of molecule-receptor interactions; the determination of posttranslational modifications of peptides; and the location of S-S bridges in determining the tertiary structure of proteins.

• Structural elucidation
• fungi
• protein
• proteins
• receptor
• translation

• Department of Organic Chemistry, University of Bern, Bern, Switzerland

  Urs Peter Schlunegger

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