Hepatic Transport of Organic Substances

1. Front Matter

   Pages I-XV

   PDF

2. General Aspects of Hepatic Transport

   1. Front Matter

      Pages 1-1

      PDF

   2. Glutamate-sodium Cotransport in the Kidney: An Example for the Plasticity of Transport Systems

      • Rolf K. H. Kinne

      Pages 3-11

   3. Energetic Coupling in Secondary Active Transport

      • E. Heinz

      Pages 12-20

   4. The Passage of Molecules into Bile: Paracellular and Transcytotic Pathways

      • W G M Hardison, P J Lowe

      Pages 21-32

   5. Increase in Paracellular Permeability as a Pathophysiological Principle of Drug-Induced Intrahepatic Cholestasis in Rats

      • H. Krell

      Pages 33-34

   6. The Hepatocyte’s Plasma Membrane Domains. Interrelations with the Endocytic Compartment

      • W. Howard Evans, Carlos Enrich

      Pages 35-44

   7. Hepatic Spaces and Transport in the Perfused Liver

      • J. Reichen

      Pages 45-57

   8. New Methodologic Approaches for the Study of Transport in the Liver

      • J. L. Boyer, J. Graf, A. Gautam

      Pages 58-73

   9. Transport Processes in Mammalian Gallbladder and Bile Duct

      • K.-U. Petersen

      Pages 74-84

   10. Transcellular Butyrate Transport in Gallbladder Epithelium

       • K.-U. Petersen, F. Wehner, J. M. Winterhager

       Pages 85-86

   11. Accessibility of Primary Bile in Liver Cell Culture

       • F. Wehner, E. Petzinger, H. Acker, J. Hentschel, R. K. H. Kinne

       Pages 87-88

   12. Polarity of the Hepatocyte Surface Membrane: Influence of Lipids on Protein Function

       • F. R. Simon

       Pages 89-101

   13. ATP in and Around the Bile Canaliculus

       • Irwin M. Arias

       Pages 102-117

3. Physiology, Pharmacology, and Biochemistry of Hepatic Transport Systems

   1. Front Matter

      Pages 119-119

      PDF

   2. Hepatic Transport of Glutathione-Conjugates

      1. Glutathione Conjugate Transport in Hepatic Elimination of Electrophiles

         • H. Sies

         Pages 121-130

      2. Hepatobiliary Cysteinyl Leukotriene Elimination

         • M. Huber, T. Baumert, A. Guhlmann, D. Mayer, D. Keppler

         Pages 131-140

      3. Biliary Excretion of Thiols and Their Role in Elimination of Methylmercury

         • Curtis D. Klaassen, Zoltan Gregus

         Pages 141-153

   3. Hepatic Transport of Amino Acids

      1. Glutamine and Glutamate Transport in Perfused Liver

         • Dieter Häussinger

         Pages 157-166

      2. Regulation of Hepatic Amino Acid Transport and Partial Purification of the System A Carrier

         • M. S. Kilberg

         Pages 167-176

Hepatic cells are involved in the metabolization and elimination of a variety of endogenous and exogenous substances. They mediate the uptake, processing and subsequent secretion of biliary compounds, such as various drugs or hormones, and the passage of metabolites to be released into different blood compartments. To perform vectorial passages hepatocytes show a strong polarity with sites for endocytotic processes or specific carrier molecules, and a specified system of organelles for intracellular transport and sorting, metabolization and secretion of compounds. Several aspects, e.g. regulation, control and mechanisms of hepatic traffic are reported in detail - complemented by methodological approaches to analyse and monitor these processes.

• ATP
• Activation
• Alanin
• Amino acid
• Glutamat
• Glutamin
• Monoclonal Antibodies
• Vivo
• biochemistry
• influence
• mercury
• metabolism
• physiology
• regulation
• hepatology

• Institut für Pharmakologie und Toxikologie, Universität Gießen, Gießen, Germany

  Ernst Petzinger

• Max-Planck-Institut für Systemphysiologie, Dortmund 1, Germany

  Rolf K. H. Kinne

• Institut für Physiologische Chemie I, Universität Düsseldorf, Düsseldorf 1, Germany

  Helmut Sies

Policies and ethics