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Hepatic Transport of Organic Substances

  • Conference proceedings
  • © 1989

Overview

Editors:
  1. Ernst Petzinger

    1. Institut für Pharmakologie und Toxikologie, Universität Gießen, Gießen, Germany

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  2. Rolf K. H. Kinne

    1. Max-Planck-Institut für Systemphysiologie, Dortmund 1, Germany

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  3. Helmut Sies

    1. Institut für Physiologische Chemie I, Universität Düsseldorf, Düsseldorf 1, Germany

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Part of the book series: Proceedings in Life Sciences (LIFE SCIENCES)

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Table of contents (47 papers)

  1. Front Matter

    Pages I-XV
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  2. General Aspects of Hepatic Transport

    1. Front Matter

      Pages 1-1
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    2. Glutamate-sodium Cotransport in the Kidney: An Example for the Plasticity of Transport Systems

      • Rolf K. H. Kinne
      Pages 3-11

    3. Energetic Coupling in Secondary Active Transport

      • E. Heinz
      Pages 12-20

    4. The Passage of Molecules into Bile: Paracellular and Transcytotic Pathways

      • W G M Hardison, P J Lowe
      Pages 21-32

    5. Increase in Paracellular Permeability as a Pathophysiological Principle of Drug-Induced Intrahepatic Cholestasis in Rats

      • H. Krell
      Pages 33-34

    6. The Hepatocyte’s Plasma Membrane Domains. Interrelations with the Endocytic Compartment

      • W. Howard Evans, Carlos Enrich
      Pages 35-44

    7. Hepatic Spaces and Transport in the Perfused Liver

      • J. Reichen
      Pages 45-57

    8. New Methodologic Approaches for the Study of Transport in the Liver

      • J. L. Boyer, J. Graf, A. Gautam
      Pages 58-73

    9. Transport Processes in Mammalian Gallbladder and Bile Duct

      • K.-U. Petersen
      Pages 74-84

    10. Transcellular Butyrate Transport in Gallbladder Epithelium

      • K.-U. Petersen, F. Wehner, J. M. Winterhager
      Pages 85-86

    11. Accessibility of Primary Bile in Liver Cell Culture

      • F. Wehner, E. Petzinger, H. Acker, J. Hentschel, R. K. H. Kinne
      Pages 87-88

    12. Polarity of the Hepatocyte Surface Membrane: Influence of Lipids on Protein Function

      • F. R. Simon
      Pages 89-101

    13. ATP in and Around the Bile Canaliculus

      • Irwin M. Arias
      Pages 102-117

  3. Physiology, Pharmacology, and Biochemistry of Hepatic Transport Systems

    1. Front Matter

      Pages 119-119
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    2. Hepatic Transport of Glutathione-Conjugates

      1. Glutathione Conjugate Transport in Hepatic Elimination of Electrophiles
        • H. Sies
        Pages 121-130
      2. Hepatobiliary Cysteinyl Leukotriene Elimination
        • M. Huber, T. Baumert, A. Guhlmann, D. Mayer, D. Keppler
        Pages 131-140
      3. Biliary Excretion of Thiols and Their Role in Elimination of Methylmercury
        • Curtis D. Klaassen, Zoltan Gregus
        Pages 141-153

    3. Hepatic Transport of Amino Acids

      1. Glutamine and Glutamate Transport in Perfused Liver
        • Dieter Häussinger
        Pages 157-166
      2. Regulation of Hepatic Amino Acid Transport and Partial Purification of the System A Carrier
        • M. S. Kilberg
        Pages 167-176
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Keywords

About this book

Hepatic cells are involved in the metabolization and elimination of a variety of endogenous and exogenous substances. They mediate the uptake, processing and subsequent secretion of biliary compounds, such as various drugs or hormones, and the passage of metabolites to be released into different blood compartments. To perform vectorial passages hepatocytes show a strong polarity with sites for endocytotic processes or specific carrier molecules, and a specified system of organelles for intracellular transport and sorting, metabolization and secretion of compounds. Several aspects, e.g. regulation, control and mechanisms of hepatic traffic are reported in detail - complemented by methodological approaches to analyse and monitor these processes.

Editors and Affiliations

  • Institut für Pharmakologie und Toxikologie, Universität Gießen, Gießen, Germany

    Ernst Petzinger

  • Max-Planck-Institut für Systemphysiologie, Dortmund 1, Germany

    Rolf K. H. Kinne

  • Institut für Physiologische Chemie I, Universität Düsseldorf, Düsseldorf 1, Germany

    Helmut Sies

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