Receptors, Membrane Transport and Signal Transduction

1. Front Matter

   Pages I-VIII

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2. G-Proteins, Adenylate Cyclase and Protein Phosphorylation

   1. Selective Regulation of G Proteins by Cell Surface Receptors

      • Elliott M. Ross

      Pages 1-24

   2. Regulation of Adenylate Cyclase in Mammalian Cells and Saccharomyces Cerevisiae

      • Alexander Levitzki

      Pages 25-37

   3. Protein Kinases, Protein Phosphatases and the Regulation of Glycogen Metabolism

      • T. G. Sotiroudis, A. E. Evangelopoulos

      Pages 38-54

   4. Phosphorylase Kinase and Protein Kinase C: Functional Similarities

      • T. G. Sotiroudis, S. M. Kyriakidis, L. G. Baltas, T. B. Ktenas, V. G. Zevgolis, A. E. Evangelopoulos

      Pages 55-66

   5. The Use of Specific Antisera to Locate Functional Domains of Guanine Nucleotide Binding Proteins

      • F. R. McKenzie, G. Milligan

      Pages 67-75

   6. Calcium Inhibits GTP-Binding Proteins in Squid Photoreceptors

      • Jenny Baverstock, Julie Fyles, Helen Saibil

      Pages 76-84

   7. Degradation of the Invasive Adenylate Cyclase Toxin of Bordetella Pertussis by the Eukaryotic Target Cell-Lysate

      • Anat Gilboa-Ron, Emanuel Hanski

      Pages 85-94

   8. Identification and Characterization of Adenylate Cyclases in Various Tissues by Monoclonal Antibodies

      • Stefan Mollner, Ulrich Heinz, Thomas Pfeuffer

      Pages 95-101

   9. The Role of G-Proteins in Exocytosis

      • Jane Stutchfield, Blandine Geny, Shamshad Cockcroft

      Pages 102-109

   10. Hydrophobic Interactions in the Calcium- and Phospholipid Dependent Activation of Protein Kinase C

       • G. T. Snoek

       Pages 110-116

   11. Activation of Transducin by Aluminum or Beryllium Fluoride Complexes

       • Joëlle Bigay

       Pages 117-126

3. Membrane Receptors and Neurotransmitters

   1. Glutamate Receptors and Glutamatergic Synapses

      • P. Ascher

      Pages 127-146

   2. Mechanisms of Glutamate Exocytosis from Isolated Nerve Terminals

      • David Nicholls, Anne Barrie, Harvey McMahon, Gareth Tibbs, Rosemary Wilkinson

      Pages 147-161

   3. Characteristics of the Epidermal Growth Factor Receptor

      • J. Boonstra, L. H. K. Defize, P. M. P. van Bergen en Henegouwen, S. W. de Laat, A. J. Verkleij

      Pages 162-185

   4. Three-Dimensional Structural Models for EGF and Insulin Receptor Interactions and Signal Transduction

      • T. Blundell, N. McDonald, J. Murray-Rust, A. McLeod, S. Wood

      Pages 186-195

   5. Potentiation of Neurotransmitter Release Coincides with Potentiation of Phosphatidyl Inositol Turnover — A Possible In Vitro Model for Long Term Potentiation (LTP)

      • D. Atlas, S. Diamant, L. Schwartz

      Pages 196-213

   6. Purification and Localization of Kainate Binding Protein in Pigeon Cerebellum

      • A. U. Klein, P. Streit

      Pages 214-222

   7. The Norepinephrine Analog Meta-Iodo-Benzylguanidine (MIBG) as a Substrate for Mono(ADP-Ribosylation)

      • C. Loesberg, H. v. Rooij, L. A. Smets

      Pages 223-232

   8. The Synaptic Vesicle Vesamicol (AH5183) Receptor Contains a Low Affinity Acetylcholine Binding Site

      • B. A. Bahr, S. M. Parsons

      Pages 233-241

A NATO Advanced study Institute on "Receptors, Membrane Trans­ port and Signal Transduction", was held on the Island of Spet­ sai, Greece, from August 16-27, 1988, in order to consider re­ cent developments in membrane receptor research, membrane trans­ port and signal transduction mechanisms. These topics were put in the larger context of current knowledge on the structure and function of membranes; connections between different fields of research were established by in-depth dis­ cussions of energy transduction and transport mechanisms. The general principles of regulation by signal transduction and protein phosphorylation/dephosphorylation were presented in the context of specific cellular processes. Discussions included al­ so the role of protein tyrosine kinases which are structurally related to oncogene products and, therefore, implicated in va­ rious aspects of cell development and transformation. This book presents the content of the major lectures and a se­ lection of the most relevant posters presented during the course of the Institute. The book is intended to make the proceedings of the Institute accessible to a larger audience and to offer a comprehensive account of those topics on receptors, membrane transport and signal transduction that were discussed extensive­ ly during the course of the Institute. February 1989 The Editors CONTENTS I. G-PROTEINS, ADENYLATE CYCLASE AND PROTEIN PHOSPHORYLATION Selective regulation of G proteins by Cell surface receptors ......... .

• Calcium
• Glutamat
• Glycogen
• Lipid
• Nucleotide
• cell
• membrane
• membrane transport
• metabolism
• neurotransmitter
• phosphorylation
• protein
• proteins
• receptor
• regulation

• Biological Research Center, The National Hellenic Research Foundation, Athens, Greece

  A. E. Evangelopoulos

• Neurobiologie Moleculaire, Institut Pasteur, Paris Cedex 15, France

  J. P. Changeux

• Membrane Bioenergetics Group, University of California, Berkeley, Berkeley, USA

  L. Packer

• Biological Research Center, The National Rellenic Research Foundation, Athens, Greece

  T. G. Sotiroudis

• Centre for Biomembranes and Lipid Enzymology, State University of Utrecht, Utrecht, The Netherlands

  K. W. A. Wirtz

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