Molecular Biology of Neuroreceptors and Ion Channels

1. Front Matter

   Pages I-XXI

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2. Introduction

   1. Common Structural Principles of Ion Channel Proteins

      • Alfred Maelicke

      Pages 1-11

3. Molecular Biology of Nicotinic Acetylcholine Receptors

   1. Brain and Muscle Nicotinic Acetylcholine Receptors: A Gene Family

      • Steve Heinemann, Jim Boulter, Evan Deneris, John Connolly, Paul Gardner, Etsuko Wada et al.

      Pages 13-30

   2. The Gene Family Encoding Neuronal Acetylcholine Receptors: Structure of the Avian Alpha2 and Alpha3 Genes

      • Sabine Couturier, Patrick Nef, Carole Oneyser, Marc Ballivet

      Pages 31-36

   3. Structure of Muscle and Neuronal Nicotinic Acetylcholine Receptors

      • Ralf Schoepfer, Paul Whiting, Mike Luther, Kent Keyser, Harvey Karten, Jon Lindstrom

      Pages 37-53

   4. Nicotinic Acetylcholine Receptors in the Nervous System of Insects

      • H. Breer, W. Hanke, D. Benke, E. Tareilus, J. Krieger

      Pages 55-68

   5. Ligand-Gated Ion Channels of Drosophila

      • Eckart D. Gundelfinger, Irm Hermans-Borgmeyer, Patrick Schloß, Erich Sawruk, Conny Udri, Martin Vingron et al.

      Pages 69-81

4. Molecular Biology of Aminoacid Receptors

   1. The Structure and Expression of the GABAA Receptor as Deduced by Molecular Genetic Studies

      • Mark G. Darlison, Eric A. Barnard, Alan N. Bateson, Thora A. Glencorse, Robert J. Harvey, Andrew A. Hicks et al.

      Pages 83-99

   2. GABAA receptor: subunit expression in Xenopus oocytes and localization of receptor mRNAs in rat brain

      • P. Malherbe, J. G. Richards, J. M. Séquier, S. Mathews, A. Draguhn, H. Möhler

      Pages 101-117

   3. Molecular Heterogeneity of GABAA-Benzodiazepine Receptors

      • W. Sieghart, K. Fuchs

      Pages 119-124

   4. The Postsynaptic Glycine Receptor — A Member of the Neurotransmitter-Gated Channel Protein Family

      • Dieter Langosch, Gabriele Grenningloh, Volker Schmieden, Peter Prior, Maria-Luisa Malosio, Bertram Schmitt et al.

      Pages 125-130

   5. Immunological identification of a neonatal glycine receptor isotype and its expression in primary cultures of spinal cord

      • Werner Hoch, Heinrich Betz, Cord-Michael Becker

      Pages 131-138

   6. Glycine receptor regulation in rodent spinal cord

      • Cord-Michael Becker, Werner Hoch

      Pages 139-148

   7. Expression-Cloning and Analysis of the Serotonin 1c Receptor from Mouse Brain

      • Hermann Lübbert

      Pages 149-161

   8. Cloned Serotonin 5HT-2 Receptor: Structure and Second Messenger Coupling

      • Dolan B. Pritchett, Alfred Bach, Omar Taleb, Roberto Dal Toso, Peter H. Seeburg

      Pages 163-173

   9. An Apparent New L-Glutamate Receptor in the Mammalian-Peripheral Nervous System

      • Pål Aas

      Pages 175-179

5. Molecular Biology of Voltage-Gated Ion Channels

   1. Molecular Properties of Voltage-Sensitive Sodium and Calcium Channels

      • William A. Catterall

      Pages 181-200

   2. Genetic and Molecular Analysis of a Gene Encoding Sodium Channels in Drosophila

      • Kate Loughney, Michael Stern, Robert Kreber, Barry Ganetzky

      Pages 201-214

   3. A Family of Potassium Channels from the Shaker Locus of Drosophila

      • T. L. Schwarz, R. Carretto, D. Papazian, B. Tempel, L. Timpe, Y.-N. Jan et al.

      Pages 215-229

   4. Molecular Basis of Biological Diversity at the Shaker Locus of Drosophila

      • A. Baumann, I. Krah-Jentgens, R. Müller, F. Müller-Holtkamp, I. Canal, J. Galceran et al.

      Pages 231-243

This workshop was the second of this series held on the island of santorini in the Cycladic Sea. The first one ("Mechanism of Action of the Nicotinic Acetylcholine Receptor", NATO ASI Se­ ries H, vol. 10) took place in May 1986 and focused on what was at the time the best studied of all neuroreceptors. This second one, held only two years later, demonstrates the im­ mense progress achieved since then in the field of neurorecep­ tors and ion channels. Molecular cloning techniques have now made available the primary structures of a whole array of ion channel proteins, and this in turn has shed light on some gen­ eral principles of the structure-function relationships of these central elements of intercellular communication. The purpose of this workshop was to explore the common ele­ ments in gene and protein structure of already cloned ion channel proteins, and to assess the status of other cloning projects in progress. It explicitly focused on very recently published and unpublished results. All participants kept to these goals thereby demonstrating the very value of such work­ shops for the progress of science.

• Energy Transduction
• Ion Channels
• Ionenkanäle
• Membranen
• Membranes
• Neuroreceptors
• Neurorezeptoren
• Receptors
• Reizleitung
• Rezeptoren
• primary structure
• proteins

• Max-Planck-Institut für Ernährungsphysiologie, Dortmund, Germany

  Alfred Maelicke

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