Microbial Resistance to Drugs

1. Front Matter

   Pages I-XVII

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2. Role of the Outer Membrane of Gram-Negative Bacteria in Antimicrobial Resistance

   • H. Nikaido

   Pages 1-34

3. Cytoplasmic Membrane Transport and Antimicrobial Resistance

   • L. E. Bryan

   Pages 35-57

4. Susceptibility and Resistance of Plasmodium falciparum to Chloroquine

   • D. J. Krogstad, P. H. Schlesinger, I. Y. Gluzman

   Pages 59-75

5. Resistance to β-Lactam Antibiotics Mediated by Alterations of Penicillin-Binding Proteins

   • B. G. Spratt

   Pages 77-100

6. Plasmid-Determined Beta-Lactamases

   • A. A. Medeiros

   Pages 101-127

7. The Chromosomal Beta-Lactamases

   • C. C. Sanders

   Pages 129-149

8. Beta-Lactamases: Genetic Control

   • S. Chamberland

   Pages 151-167

9. Resistance to Quinolones and Fluoroquinolones

   • L. J. V. Piddock

   Pages 169-192

10. Ribosomal Changes Resulting in Antimicrobial Resistance

    • H. Hummel, A. Böck

    Pages 193-225

11. Methylation of RNA and Resistance to Antibiotics

    • E. Cundliffe

    Pages 227-248

12. Resistance to Trimethoprim

    • L. P. Elwell, M. E. Fling

    Pages 249-290

13. Resistance to Sulfonamides

    • R. L. Then

    Pages 291-312

14. Chloramphenicol Acetyltransferases

    • W. V. Shaw, A. G. W. Leslie

    Pages 313-324

15. General Properties of Resistance Plasmids

    • D. E. Taylor

    Pages 325-357

16. Clinical Laboratory Testing for Antimicrobial Resistance

    • F. D. Schoenknecht

    Pages 359-385

17. The Molecular Epidemiology of Antimicrobial Resistance

    • D. M. Shlaes, C. A. Currie-McCumber

    Pages 387-410

18. Microbial Persistence or Phenotypic Adaptation to Antimicrobial Agents: Cystic Fibrosis as an Illustrative Case

    • L. E. Bryan

    Pages 411-420

19. Microbes Causing Problems of Antimicrobial Resistance

    • L. E. Bryan

    Pages 421-440

20. Back Matter

    Pages 441-454

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Most often when the subject of antimicrobial resistance is discussed, the organizational emphasis is on individual antimicrobial agents or groups of agents. Thus we tend to see discussion of resistance to f3-lactams, tetracyclines, amino­ glycosides etc. In this book many of the authors were asked to emphasize the mechanism of resistance in their discussion and from that to show how susceptibility to various agents was affected. In part this was done to help emphasize the enormous contribution that the study of antimicrobial resistance has made to our understanding of fundamental physiologic and genetic processes in bacteria. When one looks back over the study of antimicrobial resistance, it is clear that it has been the birthplace of many fundamental advances in molecular biology and of an appreciation of the role of many key functions in the life of a bacterium. In addition, and hopefully to an increasing extent in the future, such study has also contributed to advances in antimicrobial chemotherapy. Through­ out the book resistance mechanisms have been placed in perspective as to their significance as causes of resistance to key drugs or groups of drugs. Some are of much greater significance than others in terms of the prevalence or the degree of resistance produced. Whatever their numerical significance, however, each of the mechanisms, without question, throws light on fundamental cellular processes and the way in which they interact with antimicrobial agents.

• antibiotic
• antibiotics
• genetics
• methylation
• microbes
• resistance

• Department of Microbiology and Infectious Diseases, Faculty of Medicine, University of Calgary, Health Sciences Centre, Calgary, Canada

  Lawrence E. Bryan

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