Sympathetic afferent fibers originate from a visceral organ, course in the thoracolumbar rami communicantes, have cell bodies located in dorsal root ganglia, and terminate in the gray matter of the spinal cord. Sympathetic afferent fibers from the heart transmit information about noxious stimuli associated with myocardial ischemia, i. e. angina pectoris. Previous reviews have described the characteristics of cardiovascular sympathetic afferent fibers (Bishop et al. 1983; Malliani 1982). This review summarizes that work and focuses on the neural mechanisms underlying the complexities of angina pectoris. In order to understand anginal pain, cells forming the classical pain pathway, the spinothalamic tract (STn, were chosen for study. These cells were chosen to address questions about anginal pain because they transmit nociceptive informa of pain. Antidromic tion to brain regions that are involved in the perception activation of STT cells provided a means of identifying cells involved with trans mission of nociceptive information in anesthetized animals. Other ascending pathways may also transmit nociceptive information, but many studies show that the STT plays an important role. Visceral pain is commonly referred to overlying somatic structures. The pain of angina pectoris can be sensed over a wide area of the thorax: in the retrosternal, precordial anterior thoracic, and anterior cervical regions of the chest; in the left or sometimes even the right shoulder, arm, wrist, or hand; or in the jaw and teeth (Harrison and Reeves 1968).
Editors and Affiliations
Zoologisches Institut der Universität München, München 2, Germany
Hansjochem Autrum
Department of Physiology, University of North Carolina at Chapel Hill, Chapel Hill, USA
Edward R. Perl
Physiologisches Institut der Universität, Würzburg, Germany
Robert F. Schmidt
Department of Neurophysiology, Institute of Brain Research, University of Tokyo, Tokyo, Japan
Hiroshi Shimazu
The Marine Biomedical Institute, University of Texas Medical Branch, Galveston, USA
William D. Willis
Fysiologiska Institutionen II, Karolinska Institutet, Stockholm 60, Sweden
David Ottoson
Bibliographic Information
Book Title: Progress in Sensory Physiology 9
Editors: Hansjochem Autrum, Edward R. Perl, Robert F. Schmidt, Hiroshi Shimazu, William D. Willis, David Ottoson
