MHC + X

1. Front Matter

   Pages I-XXII

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2. Induction of Allospecific Cytotoxic T Cells by Virus Infections In Vivo

   • Hyekyung Yang, Raymond M. Welsh

   Pages 1-6

3. Naturally Occurring H-2 Specific Antibodies

   • P. Ivanyi, R. Černý-Provaznik, P. C. van Mourik

   Pages 7-13

4. Naturally Occurring Anti-MHC Class I Antibodies in the Rat

   • Eberhard Günther

   Pages 14-17

5. Naturally Occurring HLA Antibodies

   • M. M. Tongio, Y. Mitsuishi, A. Urlacher, S. Mayer

   Pages 18-22

6. Anti-Class I and Anti-Class II Antibodies with Monomorphic Reaction Patterns in Non-alloimmunized Human Subjects

   • Franco Ameglio, Rosa Sorrentino, Antonina Dolei, Nobuyuki Tanigaki, Roberto Tosi

   Pages 23-29

7. Antisera to “Modifying Factor” in Patients with Ankylosing Spondylitis: The Present Situation

   • A. van Leeuwen, F. P. M. J. van Bree, C. J. Beukelman, J. J. van Rood

   Pages 30-33

8. Recognition by Human B Cells of Foreign Antigen in the Context of the MHC: a Review

   • E. Goulmy, A. van Leeuwen, J. J. van Rood

   Pages 34-37

9. Searching for MHC-Restricted Antibodies: Antibodies Induced by Injections with Syngeneic Cells Coated with Sendai Virus, Trinitrophenyl, and Xenogeneic β ₂-Microglobulin Are Not Restricted by the Mouse MHC

   • Femia Kievits, Walter J. Boerenkamp, Pavol Ivanyi

   Pages 38-49

10. Searching for MHC-Restricted Monoclonal Antibodies Recognizing the Determinants Seen by Anti-Influenza Virus Cytotoxic T-Lymphocyte Receptors

    • Wendy L. Tamminen, Brian H. Barber

    Pages 50-60

11. Immunization with Fibroblasts Transfected with a Cloned Retroviral DNA Induces H-2 Specific Antibodies in Syngeneic Recipients

    • Marika Pla, Adam Opolski, Anna Rocca, Laurent Degos

    Pages 61-65

12. Sendai Virus Infection of Tumor Cells Increases the Production of Autoreactive H-2 Specific Antibodies in Syngeneic Recipients

    • Adam Opolski, Laurent Degos, Marika Pla

    Pages 66-71

13. Immunization with Fibroblasts Expressing Human β ₂-Microglobulin Induces H-2 Specific Antibodies in Syngeneic Recipients

    • Anna Rocca, Laurent Degos, Marika Pla

    Pages 72-76

14. MHC-Specific Monoclonal Antibodies Induced by Injection of Syngeneic Leukemia Cells

    • Wilhelm Schmidt

    Pages 77-84

15. Monoclonal Antibodies to Murine Tumors as Probes for Genetic Analysis of Individually Specific Tumor Antigens

    • Patricia L. Ward, Hans Schreiber

    Pages 85-92

16. Syngeneic Monoclonal Antibodies Against Chemically Induced Tumors

    • Antonio Garrido, Ignacio Algarra, Concepción Delgado, Abelardo Caballero, Matias Pérez, Federico Garrido

    Pages 93-99

17. Effect of Anti-HLA Class I Monoclonal Antibodies on the Proliferation of T Cells Induced by PHA-P. Comparison with the Effect on T Cell Activation via the CD2 and CD3 Pathways

    • S. Ferrone, M. De Felice, M. C. Turco, L. Corbo, S. Venuta

    Pages 100-106

18. A Monoclonal Antibody Induced by H-2 Syngeneic ConA Blasts: Its Reactivity Pattern with Mouse and Human MHC Class I Antigens

    • Matthias Cramer, Rudolf Mierau, Wolfgang Kuon, Elisabeth Weiss, Peter J. Robinson

    Pages 107-113

19. A Problem Perplex, MHC + X

    • Peter Parham

    Pages 114-118

20. MHC-Restricted Antibodies: Facts and Interpretation

    • Pavol Ivanyi, Femia Kievits

    Pages 119-127

After the discovery of the function of MHC molecules, namely to provide the context for T cell recognition of foreign antigens, in 1974 Zinkernagel and Doherty made the first drawing of MHC+X (Fig. 1 from Zinkernagel and Doherty, Nature, 251: 547, 1974). Over the next 18 years a very large number of similar drawings ensued, some of real artistic beauty. One side of the problem, the nature of the T cell receptor, was unraveled; however, we still do not know exactly what kind of a structure the T cell receptor recognizes, al­ though in 1987 we learned so much about the structure of MHC molecules and antigen presentation. In schematic presentations no one is now placing the foreign antigen beside the MHC molecule, but rather on top of it, as pointed out by J. L. Strominger at the MHC + X meeting in Paris. The complex of MHC and antigen is named MHC + X, but the precise meaning of this formula remains a "problem perplex", as illustrated in these proceedings by Peter Par­ ham. When planning the Ommen/Amsterdam meeting at the begin­ ning of 1987, its major aim was seen as to discuss the question of whether MHC + X can induce antibodies and, consequently, their specificity. In other terms, whether - in analogy to antigen specific MHC restricted T cells - MHC restricted antibodies also exist.

• antibody
• antigen
• histocompatibility

• Central Laboratory of the Netherlands, Red Cross Blood Transfusion Service and Laboratory for Experimental and Clinical Immunology, University of Amsterdam, Amsterdam, The Netherlands

  Pavol Ivanyi

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