New Frontiers in Cytology

1. Front Matter

   Pages I-XXX

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2. Special Article

   1. Front Matter

      Pages 1-1

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   2. Cytology in Germany

      • E. Sprenger

      Pages 3-9

3. Incoming Methods: Cell Culture, In Situ Hybridization, Cytogenetics

   1. Front Matter

      Pages 11-11

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   2. In Situ Hybridization: An Overview

      • M. van der Ploeg, A. K. Raap

      Pages 13-21

   3. In Situ Hybridization: Its Use as a Tool in Pathology Laboratories

      • S. Malcolm, J. van den Berghe

      Pages 22-26

   4. Correlations of Malignancy in Cultured Cells

      • M. M. Mareel, F. M. Van Roy, L. Messiaen, N. Van Larebeke, E. Boghaert

      Pages 27-31

   5. Cytological Analysis of Functional Alterations in Granulocytes

      • G. F. Fischer, O. Majdic, W. Knapp

      Pages 32-36

   6. Perspectives of Cytogenetic Analysis of Human Solid Tumors

      • A. Verhest

      Pages 37-40

   7. Relationships Between Morphological Variants and Cytogenetic Findings in Acute Promyelocytic Leukaemia

      • C. Di Fusco, L. Menaguale, G. Del Porto, D. Quaglino

      Pages 41-44

   8. Cytogenetic, Molecular, Immunologic, and Ultrastructural Study on an Established Cell Line of a Stage III Neuroblastoma

      • P. Grammatico, A. Modesti, S. Scarpa, S. Campo, C. Dominici, G. D’Orazi et al.

      Pages 45-49

   9. Kaposi’s Sarcoma: A Cytogenetic Study

      • P. Grammatico, A. M. Cianciulli, I. Venturo, S. Campo, R. Perrone Donnorso, G. Del Porto

      Pages 50-52

4. Viral Infections

   1. Front Matter

      Pages 53-53

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   2. Human Papillomaviruses as an Essential Factor for the Development of Cervical Cancer

      • L. Gissmann

      Pages 55-62

   3. HPV Infection of the Cervix Uteri: Prevalence and Age Distribution of a Sexually Transmissible Disease in a Cancer Screening Program

      • D. Wagner, G. Gross

      Pages 63-70

   4. Conventional Cytology is Insensitive for the Detection of Genital HPV Infection

      • A. Schneider, G. Meinhardt, E.-M. De Villiers

      Pages 71-77

   5. Alteration in Cell Morphology of a Human Neuroblastoma Line Under the Influence of Persistent Viral Infection

      • M. Halbach

      Pages 78-83

5. Quantitative Methods

   1. Front Matter

      Pages 85-85

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   2. Introduction

      • K. Goerttler

      Pages 87-89

   3. DNA Measurement: Its Value for Diagnosis and Prognosis

      • G. Auer, M. Kronenwett, A. von Rosen

      Pages 90-94

Diagnostic cytology has recently enjoyed increased attention and significance in modern research. Essential information on latest developments in methods and applications in cytology is provided by this book. Chapters review methodological advances, such as in cancer detection, and explore potential relationships to molecular biology. Also discussed are: viral infection, fundamentals of quantitative methods, and the revolutionary role of immunocytochemistry in diagnostic cell typing. The new insights offered by transmission and scanning electron microscopy into cellular structure and function are discussed, and the connections between cytology and histology are highlighted. Epidemiology in connection with cytology is incorporated in special reports. The current developments described here will become routine methods of the cytology of tomorrow.

• biology
• cancer
• cell
• cell culture
• cytogenetics
• cytology
• electron microscopy
• genetics
• histology
• infection
• microscopy
• molecular biology

• Deutsches Krebsforschungszentrum, Heidelberg, Federal Republic of Germany

  Klaus Goerttler

• Institut für Vergleichende und Experimentelle Pathologie der Universität, Heidelberg, Federal Republic of Germany

  Georg E. Feichter

• Abteilung Innere Medizin, Diakonissenhospital, Karlsruhe, Federal Republic of Germany

  Siegfried Witte

Policies and ethics