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Acarbose for the Treatment of Diabetes Mellitus

  • Conference proceedings
  • © 1988

Overview

Editors:
  1. W. Creutzfeldt

    1. Abteilung Gastroenterologie und Endokrinologie Zentrum Innere Medizin, Georg-August-Universität Göttingen, Göttingen, Germany

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Table of contents (62 papers)

  1. Front Matter

    Pages I-XVI
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  2. Introduction

    1. Introduction

      • W. Creutzfeldt
      Pages 1-2

  3. Experimental Data on Acarbose I

    1. Front Matter

      Pages 3-3
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    2. Toxicology of Acarbose, with Special Reference to Long-term Carcinogenicity Studies

      • G. Schlüter
      Pages 5-14

    3. Discussion

      • W. Creutzfeldt
      Pages 15-16

    4. The Disposition and Pharmacokinetics of Acarbose in Man

      • F. O. Müller, H. K. L. Hundt, H. G. Luus, M. van Dyk, G. Groenewoud, I. Hillebrand
      Pages 17-24

    5. Discussion

      • W. Creutzfeldt
      Pages 25-26

  4. Experimental Data on Acarbose II

    1. Front Matter

      Pages 27-27
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    2. The Pharmacological Rationale of Diabetes Mellitus Therapy with Acarbose

      • W. Puls, H. Bischoff
      Pages 29-38

    3. Discussion

      • W. Creutzfeldt
      Pages 39-40

    4. Pharmacodynamics of Acarbose: Clinical Investigations

      • B. Lembcke
      Pages 41-52

    5. Discussion

      • W. Creutzfeldt
      Pages 53-54

  5. Posters

    1. Front Matter

      Pages 55-55
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    2. Comparative Effects of Acarbose on Glycemia, Weight Gain, and Serum Lipids in Adult Male and Female Diabetic Wistar Fatty Rats

      • O. L. Tulp, C. Stevens, O. Barbee, M. L. Apostolou, O. E. Michaelis
      Pages 57-57

    3. Effects of Low-Dose Acarbose on Glycemia, Adiposity, and Cholesterolemia in Obese and Obese Non-Insulin-Dependent Diabetic Corpulent Rats

      • O. L. Tulp, S. P. DeBolt, L. Pietrangelo, R. Schnitzer-Polokoff, A. Abdollahi, M. E. Hess et al.
      Pages 58-58

    4. A Preclinical Study on the Effects of Acarbose on Mice Rendered Obese with Gold Thioglucose

      • I. Marot, Y. le Marchand-Brustel
      Pages 59-59

    5. Enhancement of Insulin Binding and Glucose Transport by Acarbose in Adipocytes of Zucker Rats

      • J. R. Vasselli, T. Flory, S. K. Fried
      Pages 60-60

    6. Treatment of Streptozotocin-Diabetic Rats with Acarbose: Influence on Metabolism and Heart Function

      • P. Rösen
      Pages 61-61

    7. Effects of Acarbose on Cardiac and Hepatic Metabolism in Diabetic Rats

      • M. E. Hess, N. Haugaard, A. Torbati, A. Rastogi, O. L. Tulp
      Pages 62-62

    8. Effects of Acarbose on Experimental Diabetic Nephropathy, Metabolic Control, and Intestinal Glycosidase Activity in Normal and Genetically Diabetic Mice

      • S. M. Lee
      Pages 63-63
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Keywords

About this book

New principles for the treatment of diabetes are described in this volume. Experts present experimental and clinical data on treatment with acarbose, an alpha-glucosidase inhibitor that delays absorption of fast carbohydrates. Toxicologic, pharmacologic and metabolic effects of acarbose are discussed. A concluding section on the future aspects of alpha-glucosidase inhibition offers a fair assessment of therapeutic possibilities.

Editors and Affiliations

  • Abteilung Gastroenterologie und Endokrinologie Zentrum Innere Medizin, Georg-August-Universität Göttingen, Göttingen, Germany

    W. Creutzfeldt

Bibliographic Information

  • Book Title: Acarbose for the Treatment of Diabetes Mellitus

  • Editors: W. Creutzfeldt

  • DOI: https://doi.org/10.1007/978-3-642-73583-7

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1988

  • Softcover ISBN: 978-3-540-19145-2Published: 22 November 1988

  • eBook ISBN: 978-3-642-73583-7Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XVI, 198

  • Number of Illustrations: 3 b/w illustrations

  • Topics: Metabolic Diseases, Pharmacology/Toxicology, Nephrology, Cardiology

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