Immune Consequences of Trauma, Shock, and Sepsis

1. Front Matter

   Pages I-XX

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2. General Aspects

   1. Front Matter

      Pages 1-1

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   2. The Immune Consequences of Trauma: An Overview

      • J. L. Ninnemann

      Pages 3-8

   3. Trauma: Immune Deficiency, Immune Suppression, or Just Immune Cell Redistribution?

      • W. L. Olszewski, I. Grzelak

      Pages 9-15

   4. Neuroendocrine Response to Severe Trauma and Sepsis

      • A. E. Baue

      Pages 17-32

3. Trauma and Specific Immune Mechanisms

   1. Front Matter

      Pages 33-33

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   2. Monocyte T-Cell Interaction and Its Mediators

      1. Regulation of Hematopoiesis by Growth Factors: Proliferation of the Murine Macrophage as a Model for Stimulatory and Inhibitory Effects

         • L. J. Guilbert, D. R. Branch

         Pages 35-44

      2. The Activation of Immune Effector Cells: Role of Helper and Inflammatory CD4 T Cell Subsets

         • K. Bottomly, C. A. Janeway Jr.

         Pages 45-54

      3. The Role of Inhibitory Cells in Burn Trauma-Associated Immunodeficiency

         • D. R. Green, R. Marcotte, N. Wang

         Pages 55-62

      4. Macrophage — T-Cell Interactions in Surgical Sepsis

         • C. C. Baker

         Pages 63-68

      5. The Relationship Between T Cells and Interleukin 1

         • S. K. Durum, K. Muegge, F. Aiello, L. Takacs

         Pages 69-77

      6. Trauma-Induced Alterations of the Lymphokine Cascade

         • E. Faist, W. Ertel, A. Mewes, S. Alkan, A. Walz, T. Strasser

         Pages 79-94

      7. Alterations of Monocyte Function Following Major Injury

         • C. L. Miller-Graziano, G. Szabo, T. Takayama, Jia-yan Wu

         Pages 95-108

      8. Possible Use of the Monocyte/Macrophage Activation Marker Neopterin for Clinical Monitoring of Sepsis-Related Multiorgan Failure

         • H. Redl, W. Strohmaier, G. Schlag, R. Pacher, W. Woloszczuk, D. Inthorn et al.

         Pages 109-114

      9. Expression of Functional Interleukin 2 Receptors in Burn Patients May Be Regulated by Interleukin 3

         • J. A. Teodorczyk-Injeyan, G. B. Mills, B. G. Sparkes, W. J. Peters

         Pages 115-118

      10. Role of Monocyte HLA-DR Expression Following Trauma in Predicting Clinical Outcome

          • W. G. Cheadle, M. J. Hershman, S. R. Wellhausen, H. C. Polk Jr.

          Pages 119-122

      11. Early Alterations in HLA Class II Expression and Response to Tetanus Toxoid by Peripheral Blood Monocytes from Patients with Injury from Burns or Trauma

          • R. A. S. Gibbons, O. M. Martinez, V. Lim, R. Lim, J. Horn, M. R. Garovoy

          Pages 123-129

      12. Lymphocyte Surface Antigen Expression Following Lectin Stimulation: An Index of Early T-Cell Dysfunction After Controlled Murine Injury

          • M. A. Gadd, C. S. Soderberg, A. N. Ozkan, J. F. Hansbrough

          Pages 131-136

      13. Role of T-Cell Lymphocyte Populations and Their Products as Mediators of Immune Depression in Thermal Burns

          • J. Demarinis, S. E. Briggs

          Pages 137-141

   3. Trauma and B-Cell Function

      1. The Influence of Mechanical Trauma on the B-Cell System: Phenotypes, Terminal B-Cell Maturation, Immunoglobulin Synthesis and Influence of Lymphokines

         • W. Ertel, E. Faist

         Pages 143-156

Sepsis and infection are the major enemies of the intensive care patient in whom immunological defenses are severely impaired. This major problem is thefocus of attention in this book, based on the presentation of the First International Congress on the Immune Consequences of Trauma, Shock, and Sepsis, which is one of the first attempts to exchange ideas on the state-of-the-art in this area of immunology. Both basic and clinical research, including new centres of attention, are described. The growing role of immunology in medicine opens new avenues to the under- standing of trauma and sepsis and will allow the design of novel therapeutic approaches.

• Sepsis
• Trauma
• care
• clinical trial
• immunology
• immunosuppression
• infection
• intensive care
• shock
• Trauma Surgery

• Dept. of Surgery, LM University Munich Klinikum Großhadern, Munich 70, Germany

  Eugen Faist

• University of California, San Diego, USA

  John L. Ninnemann

• University of Alberta Edmonton, Canada

  Douglas R. Green

Policies and ethics