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Surfactant Replacement Therapy

in Neonatal and Adult Respiratory Distress Syndrome

  • Conference proceedings
  • © 1988

Overview

Editors:
  1. Burkhard Lachmann

    1. Department of Anesthesiology, Erasmus University, Rotterdam, The Netherlands

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Table of contents (45 papers)

  1. Front Matter

    Pages I-XXII
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  2. Pulmonary Surfactant: Evolution of Functional Concepts

    1. Pulmonary Surfactant: Evolution of Functional Concepts

      • G. Enhorning
      Pages 1-9

  3. Experimental Evaluation of Surfactant for Replacement Therapy

    1. Front Matter

      Pages 11-11
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    2. Evaluation of Pulmonary Surfactant

      • G. Enhorning
      Pages 13-17

    3. Some Remarks on the Use of Physico-Chemical Methods in Lung Surfactant Research

      • P. Gieles, T. Key, J. Van Santvoort, A. Steeghs
      Pages 18-27

    4. In Vivo Tests for Evaluation of Pulmonary Surfactant

      • B. Lachmann
      Pages 28-36

    5. Efficacy and Standardisation of SF-RI 1: A Preparation from Bovine Lung Surfactant

      • B. Disse, L. Gortner, E. Weller, H. Eberhardt, H. Ziegler
      Pages 37-41

    6. Comparison Between Natural and Artificial Surfactant Preparations in Premature Rabbit Fetuses

      • B. Disse, E. Weller, L. Lützen, H. Ziegler, H. Eberhardt
      Pages 42-46

  5. Surfactant Replacement in Newborn Infants

    1. Front Matter

      Pages 89-89
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    2. Factors Affecting the Response to a Postnatal Single Dose of a Reconstituted Bovine Surfactant (Surfactant TA)

      • T. Fujiwara, M. Konishi, S. Chida, H. Maeta
      Pages 91-107

    3. A Multicenter Randomized Trial of Surfactant Replacement with Calf Lung Surfactant Extract: Effects of Pre- and Post-Ventilatory Instillation and of Multiple Doses

      • J. W. Kendig, R. H. Notter, J. M. Davis, A. Bartoletti, H. S. Dweck, H. M. Risemberg et al.
      Pages 108-122

    4. The European Multicenter Trial of Surfactant Replacement in Neonatal Respiratory Distress Syndrome

      • B. Robertson
      Pages 123-126

    5. Use of Surfactant in Very Low Birth Weight Infants with Severe Respiratory Distress Syndrome: Initial Experience and Problems

      • T. A. Clarke, S. Gormally, A. Bergin, M. King, T. G. Matthews
      Pages 127-132

    6. Surfactant Replacement with SF-RI 1 in Premature Infants with Respiratory Distress Syndrome: A Clinical Pilot Study

      • L. Gortner, F. Pohlandt, P. Bartmann, B. Disse, E. Weller
      Pages 133-133

    7. Ventilator Settings After Surfactant Replacement with SF-RI 1: Clinical Experiences

      • L. Gortner, F. Pohlandt, P. Bartmann, B. Disse, E. Weller
      Pages 134-135
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Keywords

About this book

I am very happy and honoured to have so many famous contrib­ utors from around the world presenting their knowledge and experience in this book, including Dr. Rufer who, as early as 1967, attempted to improve the pressure-volume curve of a child dying from RDS using dried surfactant from dogs; Drs. Enhorn­ ing and Robertson who were the first to treat rabbit fetuses with surfactant replacement and impressively demonstrated that sur­ factant improved lung mechanics; and Dr. Fujiwara who at the end of the 1970's had already successfully treated the first babies with surfactant replacement and published this work al­ ready in 1980. Thus, the idea of surfactant replacement therapy is now more or less 20 years old and almost 10 years have passed since the first publication by Dr. Fujiwara of his impressive clinical results. Up to now (September, 1988) about 2,200 babies have been treated worldwide with tracheal instillation of surfactant, with most promising results. The type of surfactant used varies from pure natural extracts from bovine or pig lungs, to surfactant extracted from human amniotic fluid, to pure phospholipids. To date, however, there is still no surfactant commercially available (except in Japan), in spite of the fact that it is urgently awaited by neonatologists and intensive care doctors throughout the world. This volume is based on the contributions presented at the international congress on Surfactant Replacement Therapy which was held in Rotterdam, The Netherlands, in November 1987.

Editors and Affiliations

  • Department of Anesthesiology, Erasmus University, Rotterdam, The Netherlands

    Burkhard Lachmann

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