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The Emergence of Drugs which Block Calcium Entry

  • Conference proceedings
  • © 1988

Overview

Authors:
  1. Ronald D. Smith

    1. Department of Pharmaceutical Research, Du Pont Critical Care, Waukegan, USA

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  2. Peter S. Wolf

    1. Sterling Drug, Inc., New York, USA

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  3. John R. Regan

    1. Rorer Central Research, Fort Washington, USA

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  4. Stanley R. Jolly

    1. East Carolina University, School of Medicine, Greenville, USA

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Part of the book series: Progress in Clinical Biochemistry and Medicine (PCBM, volume 6)

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Table of contents (9 papers)

  1. Front Matter

    Pages I-VIII
    Download chapter PDF

  2. Abstracts

    • Ronald D. Smith, Peter S. Wolf, John R. Regan, Stanley R. Jolly
    Pages 1-1

  3. Introduction: Calcium Entry Blockers (CEBs)

    • Ronald D. Smith, Peter S. Wolf, John R. Regan, Stanley R. Jolly
    Pages 2-20

  4. Current Calcium Entry Blocker

    • Ronald D. Smith, Peter S. Wolf, John R. Regan, Stanley R. Jolly
    Pages 21-43

  5. Preclinical Pharmacology

    • Ronald D. Smith, Peter S. Wolf, John R. Regan, Stanley R. Jolly
    Pages 44-72

  6. Therapeutic Indications

    • Ronald D. Smith, Peter S. Wolf, John R. Regan, Stanley R. Jolly
    Pages 73-102

  7. Adverse Effects

    • Ronald D. Smith, Peter S. Wolf, John R. Regan, Stanley R. Jolly
    Pages 103-111

  8. Perspectives: CEB New Drug Discovery

    • Ronald D. Smith, Peter S. Wolf, John R. Regan, Stanley R. Jolly
    Pages 112-114

  9. Acknowledgement

    • Ronald D. Smith, Peter S. Wolf, John R. Regan, Stanley R. Jolly
    Pages 114-114

  10. References

    • Ronald D. Smith, Peter S. Wolf, John R. Regan, Stanley R. Jolly
    Pages 115-152

  11. Back Matter

    Pages 153-156
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Keywords

About this book

Calcium Entry Blockers (CEBs) are a new class of drugs which have been pushing back the frontiers of science and medicine for almost two decades. This report reviews some of the wealth of chemical, biological and clinical data describing the discovery and development of these compounds. The scientific importance, therapeutic benefit and marketing potential of these compounds have caused an explosion of scientific literature describing their effects in many preclinical and clinical settings. The definitional characteristics of these compounds suggest a certain predictability of their biological profile but their therapeutic usefulness varies widely dependent upon their physical properties, net hemodynamic effects, duration of action and incidence of side effects. CEBs appear uniquely suited to the treatment of the underlying complexity of cardiovascular disease. The CEBs of the future may live up to the expectations of pathophysiologically based therapeutics and allow the heart and blood vessels to outlive the cells which they support. The development of CEBs is an evolving story of epic proportions and represents the cooperative efforts of individuals in all areas of science.

Authors and Affiliations

  • Department of Pharmaceutical Research, Du Pont Critical Care, Waukegan, USA

    Ronald D. Smith

  • Sterling Drug, Inc., New York, USA

    Peter S. Wolf

  • Rorer Central Research, Fort Washington, USA

    John R. Regan

  • East Carolina University, School of Medicine, Greenville, USA

    Stanley R. Jolly

Bibliographic Information

  • Book Title: The Emergence of Drugs which Block Calcium Entry

  • Authors: Ronald D. Smith, Peter S. Wolf, John R. Regan, Stanley R. Jolly

  • Series Title: Progress in Clinical Biochemistry and Medicine

  • DOI: https://doi.org/10.1007/978-3-642-73228-7

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1988

  • Softcover ISBN: 978-3-642-73230-0Published: 16 December 2011

  • eBook ISBN: 978-3-642-73228-7Published: 07 March 2013

  • Series ISSN: 0177-8757

  • Edition Number: 1

  • Number of Pages: VIII, 154

  • Topics: Pharmacy, Cardiology, Pharmacology/Toxicology

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