Transduction Mechanisms of Drug Stimuli

1. Front Matter

   Pages I-IX

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2. Transduction

   1. Front Matter

      Pages 1-1

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   2. Drugs as Chemical Stimuli

      • R. L. Balster

      Pages 3-11

3. Molecular Mechanisms

   1. Front Matter

      Pages 13-13

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   2. Site-Selective Serotonin Agonists as Discriminative Stimuli

      • R. A. Glennon

      Pages 15-31

   3. Discriminative Stimulus Effects of Cholinergic Agonists and the Actions of Their Antagonists

      • I. P. Stolerman, R. Kumar, C. Reavill

      Pages 32-43

   4. Stimulus Properties of Dopaminergic Drugs: Comparisons Involving Selective Agonists and Antagonists

      • J. B. Appel, R. T. Weathersby, K. A. Cunningham, P. M. Callahan, R. L. Barrett

      Pages 44-56

   5. Central Nervous System Stimulants: Neuropharmacological Mechanisms

      • E. B. Nielsen, J. Scheel-Krüger

      Pages 57-72

   6. Discriminative Stimulus Properties of Anxiolytic and Sedative Drugs: Pharmacological Specificity

      • D. J. Sanger

      Pages 73-84

   7. Comparison of Discriminative Stimuli Produced by Full and Partial Benzodiazepine Agonists: Pharmacological Specificity

      • D. A. Bennett

      Pages 85-94

   8. Receptor Mechanisms of Opioid Drug Discrimination

      • J. H. Woods, A. J. Bertalmio, A. M. Young, W. D. Essman, G. Winger

      Pages 95-106

   9. Discriminative and Analgesic Effects of Mu and Kappa Opioids: In Vivo pA2 Analysis

      • L. A. Dykstra, A. J. Bertalmio, J. H. Woods

      Pages 107-121

   10. Receptor Mediation of the Discriminative Stimulus Properties of Phencyclidine and Sigma-Opioid Agonists

       • R. L. Balster, J. Willetts

       Pages 122-135

4. Theory, Concepts, and Research Strategies

   1. Front Matter

      Pages 137-137

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   2. Neural Mechanisms of Drug Stimuli: Experimental Approaches

      • S. G. Holtzman, K. W. Locke

      Pages 139-153

   3. Intrinsic Activity and Discriminative Effects of Drugs

      • F. C. Colpaert

      Pages 154-160

   4. Relationship Between the Discriminative Stimulus Properties and Subjective Effects of Drugs

      • C. R. Schuster, C. E. Johanson

      Pages 161-175

   5. Similarities and Differences Between Behavioral Control by Drug-Produced Stimuli and by Sensory Stimuli

      • D. A. Overton

      Pages 176-198

   6. Discrimination Strategies in Animal Psychophysics and Their Role in Understanding Sensory Receptor Function

      • W. C. Stebbins, D. W. Smith, D. B. Moody

      Pages 199-214

   7. Molecular Transduction Mechanisms in ACTH-Induced Grooming

      • W. H. Gispen, D. L. Colbern, B. M. Spruijt

      Pages 215-231

In this book the latest data available on transduction mechanisms of drug stimuli are presented. A common theme underlying the chapter in this volume is the recognition that drugs can act as stimuli, in much the same manner as external events do. Accordingly, the papers focus on the mechanisms by which these stimuli are transduced at different levels of analysis, such as the behavioral, pharmacological, and molecular levels. Some chapters discuss the mechanisms of transduction of the discriminative effects of several important classes of drugs, while others deal with the methods and research strategies by which these mechanisms can be analyzed. Collectively, the papers in this volume reflect the current status of knowledge in the rapidly expanding field of behavioral pharmacology.

• cognition
• dopamine
• drug
• nervous system
• neural mechanisms
• opioid
• pharmacology
• research
• serotonin

• FONDAX-Groupe de Recherches Servier, Puteaux, France

  F. C. Colpaert

• Department of Pharmacology and Toxicology Medical College of Virginia, Virginia Commonwealth University, Richmond, USA

  R. L. Balster

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