The Pharmacology of Lymphocytes

1. Front Matter

   Pages I-XXII

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2. Glossary of Common Immunological Terms

   1. Glossary of Common Immunological Terms

      • Michael A. Bray, John Morley

      Pages 1-8

3. Part 1

   1. Front Matter

      Pages 9-9

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   2. The Evolution, Ontogeny, and Physiologic Function of Lymphocytes

      • J. Klein

      Pages 11-36

   3. De Novo Expression of Receptors on T Cells

      • J. M. Williams, T. B. Strom

      Pages 37-52

   4. Membrane Events During Lymphocyte Activation

      • J. T. Ransom, J. C. Cambier

      Pages 53-82

   5. Intracellular Events During Lymphocyte Activation

      • R. G. Coffey

      Pages 83-138

4. Part 2

   1. Front Matter

      Pages 139-139

      PDF

   2. Generation and Measurement of Antibodies

      • H. F. J. Savelkoul, S. S. Pathak, N. R. Sabbele, R. Benner

      Pages 141-185

   3. Monoclonal Antibodies to Lymphocyte Surface Molecules as Probes for Lymphocyte Functions

      • M. A. Talle, G. Goldstein

      Pages 187-213

   4. Interleukin 1 Production from Various Cells and Measurement of its Multiple Biologic Activities

      • C. A. Dinarello

      Pages 215-234

   5. Production and Measurement of Interleukin 2 and Interleukin 3

      • B. M. Stadler, K. Hirai, J.-F. Gauchat

      Pages 235-253

   6. Production and Measurement of Interferons

      • S. S. Alkan

      Pages 255-274

   7. Factors Regulating IgE Synthesis

      • C. Gaveriaux, T. Payne, F. Loor

      Pages 275-290

   8. Generation, Biology, and Assay of Efferent Lymphokines

      • D. Gemsa

      Pages 291-318

   9. Lymphocyte Purification, Growth, Cloning and Functional Assays

      • M. J. H. Ratcliffe, J. R. Lamb

      Pages 319-343

   10. Screening Strategies for Detecting Immunotherapeutic Agents

       • S. C. Gilman, R. T. Maguire, A. J. Lewis

       Pages 345-360

5. Part 3

   1. Front Matter

      Pages 361-361

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   2. Selected Autacoids as Modulators of Lymphocyte Function

      • M. M. Khan, K. L. Melmon

      Pages 363-383

   3. Lipid Mediators and Lymphocyte Function

      • M. J. Parnham, W. Englberger

      Pages 385-414

"Immunopharmacology" , why not "pharmacoimmunology"? Professor H. O. Schild University College London, 1962 An intact immune response is essential for survival, as is evidenced by the various innate immune deficiency syndromes and by the emergence of the acquired immune deficiency syndrome (AIDS) as a pandemic during the last decade. Substances which stimulate the immune response might contribute to the therapy of AIDS and its precursor, AIDS-related syndrome, as well as of other clinical conditions in which immune responses can be diminished, such as carcinoma and infections. In other circumstances, an intact or heightened immune response may pose clinical problems; hence there is need to suppress, or diminish, components of the immune response. For instance, it is necessary to impair cellular immunity in order to ensure lasting acceptance of heterografts and it is already established that agents effective in transplantation are therapeutically effective in an range of autoimmune diseases. More recently, experimental studies have indicated that aberrant manifestations of humoral immunity, as in allergies, may also be amenable to pharmacological intervention.

• biochemistry
• immunology
• immunotherapy
• lymphocytes
• pharmacology

• Research Department, CIBA-GEIGY AG, Basel, Switzerland

  Michael A. Bray

• Pharmaceutical Division, Preclinical Research, SANDOZ Ltd., Basel, Switzerland

  John Morley

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