Molecular Basis of Viral and Microbial Pathogenesis

1. Front Matter

   Pages I-IX

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2. Correlation Between Viroid Structure and Pathogenicity

   • H. L. Sänger, B. Haas

   Pages 1-20

3. Antigenicity of the Influenza Haemagglutinin Membrane Glycoprotein

   • J. J. Skehel, D. C. Wiley

   Pages 21-24

4. Viral Glycoproteins as Determinants of Pathogenicity

   • H.-D. Klenk, M. Tashiro, W. Garten, R. Rott

   Pages 25-38

5. Virus Genes Involved in Host Range and Pathogenicity

   • C. Scholtissek

   Pages 39-50

6. Molecular Heterogeneity of Pathogenic Herpes Viruses

   • M. Mach, H. H. Niller, B. Fleckenstein

   Pages 51-59

7. Recombination of Foreign (Viral) DNA with the Host Genome Studies in Vivo and in a Cell-Free System

   • W. Doerfler, A. Spies, R. Jessberger, U. Lichtenberg, C. Zock, T. Rosahl

   Pages 60-72

8. Disorders of Cellular Neuro-Functions by Persistent Viral Infections

   • K. Koschel

   Pages 73-84

9. Pathogenetic Aspects of Measles Virus-Persistent Infections in Man

   • V. ter Meulen

   Pages 85-90

10. Analysis of the Dual Lineage Specificity of E26 Avian Leukemia Virus

    • T. Graf, S. Grieser, M. Nunn

    Pages 91-94

11. Mx Gene Control of Influenza Virus Susceptibility

    • O. Haller, P. Staeheli

    Pages 95-101

12. Shiga and Shiga-Like Toxins: A Family of Related Cytotoxins

    • A. D. O’Brien, M. P. Jackson, L. R. M. Marques, N. A. Strockbine, D. L. Weinstein, M. A. Moore et al.

    Pages 102-108

13. Molecular Mechanisms of Pathogenicity in Shigella flexneri

    • P. J. Sansonetti, B. Baudry, P. Clerc, A. T. Maurelli, X. Nassif, A. Ryter

    Pages 109-113

14. Antigenic Variation of Proteins on the Surface of Pathogenic Neisseriae

    • T. F. Meyer, R. Haas, A. Stern

    Pages 114-122

15. Molecular and Antigenic Architecture of the Antiphagocytic Group A Streptococcal M Protein

    • V. A. Fischetti, K. F. Jones, S. Hollingshead, J. R. Scott

    Pages 123-131

16. Bacterial Cytolysins that Form Transmembrane Pores

    • S. Bhakdi, J. Tranum-Jensen

    Pages 132-140

17. Bacterial Cytolysins — Extracellular Proteins and Virulence Factors

    • S. Kathariou, J. Hacker, H. Hof, I. Then, W. Wagner, M. Kuhn et al.

    Pages 141-150

18. Iron as a Signal in Bacterial Infections

    • V. Braun, E. Fischer, K. Hantke, H. Rotering

    Pages 151-159

19. Clostridial Neurotoxins — The Search for a Common Mode of Action

    • E. Habermann

    Pages 160-175

20. Stage-Specifically Expressed Antigens and Genes in Trypanosoma cruzi

    • G. Harth, C. G. Haidaris, M. So

    Pages 176-185

Elucidation of the mechanisms of pathogenesis underlying the diseases caused by viruses and bacteria has fascinated scientists for many years in two ways. Firstly, these pathogenic agents represent relatively sim­ ple biological systems for the study of basic biological processes such as replication, gene regulation, genetic variability and host-pathogen interactions. Secondly, process in this field is valuable in a practi­ cal sence, since it can help in the control of these diseases. The avail­ ability of new genetic and immunological techniques, especially recom­ binant DNA methods and monoclonal antibody technology, has provided powerful tools for unravelling the genetic, biochemical and immunologi­ cal basis of viral and microbial pathogenesis. Molecular cloning has allowed the isolation of single genes or groups of genes related to phenotypes which appear to be immunologically important for pathogene­ sis. The specific elimination of such genes from the complex genomes of the pathogens can now be achieved with similar genetic techniques. These genetic studies have provided additional information on the role played by specific phenotypic traits in pathogenesis, especially when combined with relevant animal model systems. Furthermore, the struc­ tural analysis of important virulence factors and surface antigens may allow the prediction of antigenic domains suitable for the development of new vaccines. The 38th Mosbacher Colloquium focuses on the molecular basis of viral and microbial pathogenesis. The virology part begins with the well­ studied plant viroids. The unusual structure of their genome, as well as knowledge about their replication and pathogenicity, are presented.

• Toxin
• Trypanosoma cruzi
• Viruses
• Vivo
• glycoprotein
• leukemia virus
• molecular mechanisms
• protein
• proteins
• regulation
• virology
• virulence
• virus

• Institut für Virologie der Universität, Gießen, Germany

  Rudolf Rott

• Institut für Genetik und Mikrobiologie der Universität, Würzburg, Germany

  Werner Goebel

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