Cell to Cell Signals in Mammalian Development

1. Front Matter

   Pages I-VIII

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2. Homeodomain Containing Genes: Structure and Role in Development

   1. The Murine Homeobox Protein Hox 1.1 Is Differentially Expressed in Embryonal Mesoderm and Ectoderm

      • Frank Schulze, Michael Kessel, Peter Gruss

      Pages 1-8

   2. Structure, Expression and Evolutionary Relationships of Murine Homebox Genes in the Hox 2 Cluster

      • N. Papalopulu, A. Graham, J. Lorimer, R. Kenny, J. McVey, R. Krumlauf

      Pages 9-21

   3. Regulation of Expression of the Hox 2.3 Gene

      • Frits Meijlink, Lia de Laaf, Peter Verrijzer, Wim de Graaff, Jacqueline Deschamps

      Pages 23-41

   4. The Mouse En-1 Gene Encodes a Nuclear Protein Expressed in the Nervous System of the Developing Embryo

      • Gail R. Martin, Michael A. Frohman

      Pages 43-52

   5. The Hox 1.3 Horneo Box Gene Encodes a Sequence Specific DNA Binding Phosphoprotein

      • Ward F. Odenwald, James Garbern, Heinz Arnheiter, Elizabeth Tournier-Lasserve, Hilary A. Overton, Robert A. Lazzarini

      Pages 53-61

   6. Analysis of transcription of the murine homeobox gene Hox 1.3

      • James Garbern, Ward Odenwald, Elizabeth Tournier-Lasserve, Robert Lazzarini

      Pages 63-73

   7. The Human Cognate of the Murine Hox 1.3 Horneo Box Gene is Almost Identical to its Murine Counterpart

      • Elizabeth Tournier-Lasserve, Ward F. Odenwald, James Garbern, Robert A. Lazzarini

      Pages 75-84

   8. Temporal and Cellular Specificity of Expression of the Murine Homeobox-Containing Gene Hox-1.4

      • Debra J. Wolgemuth, Margaret Mostoller, Carolyn M. Viviano, Zahra F. Zakeri, Yasuhisa Iwaoki, George L. Mutter

      Pages 85-96

   9. Murine Homeo-Genes: Some Aspects of their Organisation and Structure

      • Denis Duboule, Brigitte Galliot, Agnès Baron, Mark S. Featherstone

      Pages 97-108

3. Extracellular Matrices and Cell Adhesion Molecules

   1. Cell Adhesion in Morphogenesis

      • Jean Paul Thiery

      Pages 109-128

   2. Generation of Diversity in the NCAM Adhesion Protein of Rodents

      • C. Goridis, M.-J. Santoni, M.-R. Hirsch, J. Barbas, D. Barthels, W. Wille

      Pages 129-143

   3. Ultrastructural Localization of the Cell Adhesion Molecule Uvomorulin using Site-directed Antibodies

      • R. Kemler, H. Schwarz

      Pages 145-152

4. Growth Factors, Receptors and Oncogenes: Structure and Function

   1. Mutational Analysis of the EGF Receptor Proto-Oncogene

      • J. Schlessinger, A. M. Honegger, A. Ullrich

      Pages 153-162

   2. Activation of the Human Epidermal Growth Factor Receptor

      • L. H. K. Defize, J. Boonstra, P. M. P. van Bergen en Henegouwen, A. J. Verkley, S. W. de Laat

      Pages 163-181

   3. Insulin receptor tyrosine kinase and insulin action

      • E. Van Obberghen, S. Gammeltoft, Y. Le Marchand-Brustel, R. Ballotti

      Pages 183-192

   4. The Macrophage Colony Stimulating Factor, CSF-1, and Its Receptor (c-fms)

      • Charles J. Sherr

      Pages 193-207

   5. Signal Transduction by Growth Factor Receptors

      • W. H. Moolenaar

      Pages 209-217

5. Growth Factors, Receptors and Oncogenes: Role in Differentiation and Development

   1. Growth and Differentiation Factors of Embryonic Stem Cells

      • John K. Heath, Austin G. Smith, Alan J. Wills, Dylan R. Edwards

      Pages 219-229

   2. Regulation of Growth Factors and their Receptors in Early Murine Embryogenesis

      • C. L. Mummery, J. van den Eijnden-van Raaij, A. Feijen, H.-C. Tsung, W. Kruijer

      Pages 231-245

Developmental biology deals with the regulatory principles underlying the generation of a new organism. The up-to-date knowledge of the molecular and cellular mechanisms that guide mammalian development from a single cell through a complex and integrated process of cell multiplication, differentiation and organisation of cells into tissues and organs is presented in this volume. Aspects of the molecular nature and developmental significance of cell-to-cell signals focus on: - hoxgenes, their products and potential role in mammalian morphogenesis; - growth factors, their receptors and signal transduction, and their role in guiding cell multiplication, differentiation and transformation; and - cell adhesion and extracellular matrix molecules, as short-range cell-to-cell signals in mammalian development.

• Activation
• DNA
• carcinoma
• cell
• cellular mechanisms
• developmental biology
• gene expression
• morphogenesis
• oncogene
• oncogenes
• regulation
• stem cell
• stem cells
• tissue
• transcription

• Hubrecht Laboratory, The Netherlands Institute for Developmental Biology, Utrecht, The Netherlands

  S. W. Laat, J. G. Bluemink, C. L. Mummery

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