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Local-spinal Therapy of Spasticity

  • Conference proceedings
  • © 1988

Overview

Editors:
  1. Hermann Müller

    1. Dept. Anesthesiology and Intensive Care Medicine, Justus-Liebig-University, Gießen, Germany

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  2. Jan Zierski

    1. Dept. Neurosurgery, Justus-Liebig-University, Gießen, Germany

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  3. Richard D. Penn

    1. Dept. Neurosurgery, Rush-Presbyterian-St. Luke’s Medical Center Rush Medical College, Chicago, USA

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (21 papers)

  1. Front Matter

    Pages I-VIII
    Download chapter PDF

  2. Preface

    1. Preface

      • H. Müller, J. Zierski, R. D. Penn
      Pages 1-2

  3. A Short Historical Review of Spasticity and its Therapy

    1. A Short Historical Review of Spasticity and its Therapy

      • D. Dralle, H. Müller, J. Zierski
      Pages 3-16

  4. Basic Experiences

    1. Front Matter

      Pages 17-17
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    2. Spinal Pharmacology of Agents which Alter Pain Transmission and Muscle Tone

      • T. L. Yaksh, P. A. C. Durant, M. S. Monasky, C. W. Stevens, R. R. Schick
      Pages 19-36

    3. The Neuropharmacology of Baclofen

      • W. Zieglgänsberger, J. R. Howe, B. Sutor
      Pages 37-49

    4. Animal Experiments on the Spinal Action of Midazolam

      • H. Gerlach, H. Müller, J. Boldt, G. Hempelmann
      Pages 51-64

    5. Intrathecal Injection of Antispastic Drugs in Rats: Muscle Relaxant Action of Midazolam, Baclofen, 2-Aminophosphonoheptanoic Acid (AP7) and Tizanidine

      • M. Schwarz, T. Klockgether, L. Turski, K.-H. Sontag
      Pages 65-79

    6. CSF Compatibility of Antispastic Agents

      • U. Börner, H. Müller, J. Zierski, G. Hempelmann, M. Reinacher
      Pages 81-84

    7. Dural Permeability to Bupivacaine, Baclofen and Midazolam: In Vitro Determination with Human Dura Mater

      • J. Biscoping, G. Michaelis, D. Friess, D. Krauß, E. Mutschler, G. Hempelmann
      Pages 85-90

  5. Clinical Studies

    1. Front Matter

      Pages 91-91
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    2. Pharmacotherapy of Spasticity

      • J. Noth
      Pages 93-96

    3. Pumps in Pharmacotherapy

      • H. Müller, J. Zierski
      Pages 97-123

    4. Implantation of Ports and Pumps. Technique for Intrathecal Administration of Drugs

      • J. Zierski, H. Müller
      Pages 125-136

    5. Control of Spasticity with Intrathecal Morphine Sulfate

      • D. L. Erickson, P. Moreno, J. Lo, J. Cameron, M. Michaelson
      Pages 137-142

    6. Clinical Experience with Spinal Morphine, Midazolam and Tizanidine in Spasticity

      • H. Müller, J. Zierski
      Pages 143-150

    7. Chronic Intrathecal Baclofen for Severe Rigidity and Spasms

      • R. D. Penn
      Pages 151-153

    8. Intrathecal Baclofen in Spasticity

      • H. Müller, J. Zierski, D. Dralle, O. Hoffmann, G. Michaelis
      Pages 155-214

    9. Chronic Intrathecal Administration of Baclofen in Treatment of Severe Spasticity

      • Y. Lazorthes
      Pages 215-222

    10. Pharmacokinetics of Intrathecal Baclofen

      • H. Müller, J. Zierski, D. Dralle, D. Krauß, E. Mutschler
      Pages 223-226
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Keywords

About this book

Historical photograph of spinal anaesthesia In 1884 the American neurologist J. L. eases. His discovery, however, marks the Corning, by blocking the neural con­ onset of the era of regional anaesthesia. It took almost one hundred years until his duction to the hind extremities of a dog by injecting cocaine-solution into the lumbar original idea of "local medication of the vertebral interspace, was the first to per­ cord" was again reconsidered due to two form spinal (or epidural?) anaesthesia [1]. reasons: At that time, he was unaware of the local I. The discovery of different drug receptors anaesthetic properties of cocaine (dis­ in the spinal cord made it possible, by in­ covered in the same year by C. Koller, who trathecal injection (or epidural appli­ cation, if the drug penetrates the dura), applied cocaine to the eye of one of his pa­ tients [3]) and did not intend to introduce to alter nociceptive or motor transmis­ an anaesthetic procedure. Corning's pri­ sion within the spinal cord. mary aim was the application of drugs in 2. Implantable devices for long-term appli­ proximity of the central nervous system, i. e. cation of drugs to specific sites of the spinal cord, in order to treat or even heal body, including the spinal spaces, were developed during the 1970's.

Editors and Affiliations

  • Dept. Anesthesiology and Intensive Care Medicine, Justus-Liebig-University, Gießen, Germany

    Hermann Müller

  • Dept. Neurosurgery, Justus-Liebig-University, Gießen, Germany

    Jan Zierski

  • Dept. Neurosurgery, Rush-Presbyterian-St. Luke’s Medical Center Rush Medical College, Chicago, USA

    Richard D. Penn

Bibliographic Information

  • Book Title: Local-spinal Therapy of Spasticity

  • Editors: Hermann Müller, Jan Zierski, Richard D. Penn

  • DOI: https://doi.org/10.1007/978-3-642-72954-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1988

  • Softcover ISBN: 978-3-540-18295-5Published: 15 April 1988

  • eBook ISBN: 978-3-642-72954-6Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: VIII, 270

  • Number of Illustrations: 94 b/w illustrations

  • Topics: Pain Medicine, Neurology, Neurosurgery, Anesthesiology, Neurosciences, Internal Medicine

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