Modification of Cell to Cell Signals During Normal and Pathological Aging

1. Front Matter

   Pages I-XV

   PDF

2. Functional Morphology and Cerebral Metabolism During Normal and Pathological Aging

   1. Functional Morphology of Neurons During Normal and Pathological Ageing

      • A. N. Davison

      Pages 1-16

   2. Functional morphology during normal and pathological ageing with emphasis on peptidergic transmission

      • P C Emson, H Arai, M N Rossor

      Pages 17-25

   3. P.E.T. Study of Human Brain Metabolism in Aging and Dementia

      • P. Bustany, M. Moulin

      Pages 27-38

   4. An Experimental Approach to the Study of the Functional Derangement which Follows Aging of the Brain and Dementia

      • Cesare Fieschi, Francesco Orzi, Giovanni Diana, Francesco Pontieri

      Pages 39-45

   5. Alzheimer’s Disease Causes Metabolic Uncoupling of Associative Brain Regions Beyond that Seen in the Healthy Elderly

      • Stanley I. Rapoport, Barry Horwitz, C. L. Grady, J. V. Haxby

      Pages 47-61

3. Neurochemical, Neuroendocrine and Molecular Changes During Aging in Animals and in Man

   1. Neurotransmitters, Genetics, and Aging

      • Caleb E. Finch

      Pages 63-82

   2. Neuroendocrine Aspects of Aging

      • Joseph Meites

      Pages 83-99

   3. The Neuronotrophic Hypothesis of the Aging Brain

      • M. G. Nunzi, G. Toffano

      Pages 101-109

   4. Example of Age Related Changes of Transducing Mechanisms and of Cerebral Circuits

      • S. Govoni, F. Battaini, M. S. Magnoni, R. A. Rius, L. Lucchi, M. Trabucchi

      Pages 111-122

   5. Changes in Calcium Homeostasis During Aging

      • Gary E. Gibson, Christine Peterson

      Pages 123-140

   6. Dietary and Neuroendocrine Modulation of Age Related Changes in Dopaminergic Action During Aging

      • George S. Roth, James A. Joseph

      Pages 141-151

   7. Dopaminergic System in the Aged Brain: Evidence for a Selective Loss of D-1 But Not D-2 Receptors

      • C. Missale, M. Memo, P. F. Spano

      Pages 153-167

   8. Neurotransmitter Changes in Human Brain During Ageing

      • Oleh Hornykiewicz

      Pages 169-182

   9. The Influence of Age on Neurotransmitters in the Human Brain

      • Cora O’Neill, Jan Marcusson, Agneta Nordberg, Bengt Winblad

      Pages 183-198

4. Normal Versus Pathological Aging in Man

   1. Senile Dementias: An Overview

      • L. Amaducci, A. Lippi, S. Sorbi

      Pages 199-211

   2. Growing Points in the Neurobiology of Alzheimer’s Disease

      • M. Roth

      Pages 213-226

   3. The Alzheimer Tangle and Aging

      • C. M. Wischik, R. A. Crowther

      Pages 227-234

   4. New Perspectives in Parkinson’s Disease

      • R. F. Peppard, D. B. Calne

      Pages 235-247

   5. Guidelines of the Care of the Aged Patients

      • Francesco Antonini, Niccolò Marchionni, Luigi Ferrucci, Mauro Di Bari

      Pages 249-259

The aging process involves changes in neurotransmission at different levels. The purpose of this book is to help define the state-of-the-art of the field and to give directives for future research on the aging brain. Following topics are presented: the comparison of normal and pathological aging at the anatomical and neurochemical level; the knowledge of the responses of the aging brain to drug treatment or environmental stress; the neuro/immune and neuro/endocrine setting during aging; and the definition of therapeutical approaches in normal aging. This book will interest physicians and pathologists as well as neurophysiologists.

• Alzheimer
• Parkinson
• dopamine
• influence
• neurobiology
• neurons

• Institute of Pharmacological Sciences, University of Milano, Milano, Italy

  Stefano Govoni, Fiorenzo Battaini

Policies and ethics