The Pathology of the Endocrine Pancreas in Diabetes

1. Front Matter

   Pages I-XI

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2. Clinical Forms of Diabetes Mellitus

   • P. J. Lefèbvre

   Pages 1-16

3. The Diabetic Pancreas: A Pathologist’s View

   • J. Rahier

   Pages 17-40

4. Insulitis in the Human Pancreas

   • A. K. Foulis, G. F. Bottazzo

   Pages 41-52

5. Circulating Signs of Autoimmune Islet Disease

   • Ä. Lernmark, H. Markholst, S. Baekkeskov

   Pages 53-70

6. Immune Interactions with Islet Cells: Implications for the Pathogenesis of Insulin-Dependent Diabetes Mellitus

   • J. Nerup, T. Mandrup-PouIsen, J. Mølvig, G. Spinas

   Pages 71-84

7. Viral Interactions with Pancreatic B-Cells

   • E. H. Leiter, G. L. Wilson

   Pages 85-105

8. Death of the Pancreatic B-Cell

   • D. G. Pipeleers, P. A. In’t Veld, M. Van De Winkel

   Pages 106-124

9. Disturbed Growth of the Endocrine Pancreas

   • S. Falkmer, U. Askensten

   Pages 125-140

10. Islet Cell Replication and Diabetes

    • C. Hellerström, I. Swenne, A. Andersson

    Pages 141-170

11. Islet Cell Tumors and Diabetes Mellitus

    • G. Somers, M. De Vroede

    Pages 171-190

12. Insulin Secretion in Diabetes Mellitus

    • E. Cerasi

    Pages 191-218

13. Possible Sites for Deficient Glucose Recognition in Islet Cells

    • W. J. Malaisse

    Pages 219-232

14. Insulin Release and Islet Cell Junctions

    • P. A. In’t Veld

    Pages 233-248

15. Calcium Transport and Deficient Insulin Release

    • B. Hellman

    Pages 249-268

16. Autoimmune Diabetes in the BioBreeding/Worcester Rat

    • A. A. Like, E. J. Weringer

    Pages 269-284

17. Rat Models of Non-Insulin-Dependent Diabetes Mellitus: Evidence that Mild Increases in Plasma Glucose Play an Important Role in Pathogenesis

    • J. L. Leahy, S. Bonner-Weir, G. C. Weir

    Pages 285-309

18. Perspectives of Islet Cell Transplantation in Diabetes

    • P. E. Lacy

    Pages 310-328

19. Back Matter

    Pages 329-336

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Diabetes mellitus represents one of the most frequent and serious clinical syn­ dromes in contemporary medicine. Since the end of the nineteenth century, the endocrine pancreas has been implicated in the pathogenesis of this disease. Several pathologists of the twentieth century detected various lesions and mor­ phologic alterations in the pancreatic islets of diabetic patients, but the patho­ physiologic basis of their findings remained long obscure. The systematic mi­ croscopic work of WILLY GEPTS clarified the views and related the variety in histopathology to differences in origin, duration and clinical expression of the disease. Over the past two decades, the concept of a multifactorial origin of diabetes has become widely accepted. Various agents and mechanisms have been identified which can lead to a quantitative or qualitative deficit in pancre­ atic B-cells. The purpose of this book is to bring an update on the many path­ ways which may induce an absolute or relative insufficiency in insulin release and hence a diabetic state. Rather than bringing a complete account on all re­ search relevant to the understanding of the pathology of the diabetic pancreas, the authors of the various chapters of this volume have focussed on selected processes which can impair B-cell function, survival or regeneration.

• Diabetes
• Diabetes mellitus
• Diabetic Pancreas
• Insulin Secretion
• Insulitis
• Pancreas
• Pancreatic Islets
• growth
• insulin
• pathogenesis
• pathology
• transplantation
• metabolic disease

• Division of Diabetes, Nutrition and Metabolic Disorders Department of Medicine, Centre Hospitalier Universitaire du Sart-Tilman, Liège 1, Belgium

  Pierre J. Lefèbvre

• Dept. of Metabolism and Endocrinology, Vrije Universiteit Brussel, Brussels, Belgium

  Daniel G. Pipeleers

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