Molecular and Cellular Aspects of Erythropoietin and Erythropoiesis

1. Front Matter

   Pages I-VIII

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2. Preface

   1. Preface

      • Ivan N. Rich

      Pages 1-4

3. Acknowledgements

   1. Acknowledgements

      • Ivan N. Rich

      Pages 5-5

4. Abbreviations

   1. Abbreviations

      • Ivan N. Rich

      Pages 6-8

5. Molecular Biology of Erythropoiesis and Erythropoietin

   1. Front Matter

      Pages 9-9

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   2. The Molecular Biology of Erythropoietin and the Expression of its Gene

      • Eugene Goldwasser, Jeffrey McDonald, Nega Beru

      Pages 11-21

   3. The Molecular Biology of Erythropoietin

      • Fu-Kuen Lin

      Pages 23-36

   4. Analysis of Erythroid Cell-Specific Gene Expression

      • P. R. Harrison, J. Frampton, I. Chambers, K. Kasturi, B. Thiele, D. Conkie et al.

      Pages 37-50

   5. The Role of Oxygen Tension in the Regulation of Protein Synthesis in Erythroid Cells

      • Engin Bermek, Biyoloji Bolumu

      Pages 51-60

   6. Erythropoietin Production and Erythropoietin Receptors on Murine Erythroleukemic Cell Lines

      • C. Lacombe, N. Casadevall, J. Choppin, O. Muller, E. Goldwasser, B. Varet et al.

      Pages 61-72

   7. The Purification of Spleen CFU-E and its Applications in the Study of In Vitro Erythropoiesis

      • Willem Nijhof, Piet K. Wierenga

      Pages 73-87

   8. Use of Purified Erythropoietin Responsive Cells Produced by the Anemia Strain of Friend Virus to Study the Action of Erythropoietin

      • Sanford B. Krantz, Stephen T. Sawyer, Mark J. Kourny, Maurice C. Bondurant

      Pages 89-102

   9. Retroviral Vectors for Gene Transfer and Expression in Haematopoietic Cells

      • Nicholas Hunt, Christine Laker, Carol Stocking, Norbert Hess, Peter Nobis, Jorn Sieb et al.

      Pages 103-121

6. Back Matter

   Pages 122-125

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7. Cellular Interactions and Signals during Erythropoietic Ontogeny

   1. Front Matter

      Pages 126-126

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   2. Respective Roles of Programme and Differentiation Factors during Hemoglobin Switching in the Embryo

      • Francoise Dieterlen-Lievre

      Pages 127-145

   3. Cellular Interactions and/or Random Differentiation for the Formation of Erythroid Cells in the Early Chick Embryo

      • Nikolas Zagris

      Pages 147-163

   4. Divergence of Erythroid Restricted Precursors from Hemopoietic Stem Cells During Early Ontogeny

      • James B. Turpen, Martin F. Flajnik, Paula B. Smith

      Pages 165-175

   5. Some Endocrine Aspects of Renal and Extrarenal Erythropoietin in Normoxic and Hypoxic Rats

      • Gisela K. Clemons

      Pages 177-186

   6. Perturbation of Erythropoiesis during the Period of Early Anemia. A Model for Studying the Regulation of Erythropoiesis in the Neonatal Mammal

      • T. Sanegen, P. H. Holter, A. Haga, P. Haga, A. Meberg, S. Halvorsen et al.

      Pages 187-204

Molecular biology has provided a tool with which problems in cellular differentiation can be answered. Recombinant DNA technology has been used to obtain quantities of the erythropoietic hormone, erythropoietin. The availability of the hormone has provided a much-needed impetus in learning how erythropoiesis is controlled. Knowledge of the genetic components, transcription and translation of the erythropoietin gene and finally the release of the mature hormone under various physiological conditions should be forthcoming in the near future. This volume will give the reader some indication as to the different aspects of erythropoiesis. They include the regulation of production of the hormone under normal and abnormal conditions, ontogeny and cellular interactions and the assay of the hormone itself.

• DNA
• EPO
• Macrophages
• biology
• development
• enzyme
• enzymes
• gene
• gene expression
• gene transfer
• molecular biology
• protein synthesis
• regulation
• transcription
• translation

• Abteilung für Transfusionsmedizin, Universität Ulm DRK Blutspendezentrale, Ulm, Germany

  Ivan N. Rich

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