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Mechanisms and Models in Toxicology

Proceedings of the European Society of Toxicology Meeting Held in Harrogate, May 27–29, 1986

  • Conference proceedings
  • © 1987

Overview

Editors:
  1. Claire M. Chambers

    1. Department of Pharmacology and Therapeutics, Trinity College, University of Dublin, Dublin 2, Ireland

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  2. Philip L. Chambers

    1. Department of Pharmacology and Therapeutics, Trinity College, University of Dublin, Dublin 2, Ireland

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    You can also search for this editor in PubMed   Google Scholar

  3. Donald S. Davies

    1. Royal Postgraduate Medical School, London, UK

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Archives of Toxicology (TOXICOLOGY, volume 11)

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Table of contents (68 papers)

  1. Front Matter

    Pages I-VIII
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  2. Mechanisms of Cell Injury

    1. Front Matter

      Pages 1-1
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    2. Apoptosis: Cell Death Under Homeostatic Control

      • A. H. Wyllie
      Pages 3-10

    3. On The Role of Calcium in Chemical Toxicity

      • S. Orrenius, P. Nicotera
      Pages 11-19

    4. A Dynamic Liver Culture System: A Tool for Studying Chemical Biotransformation and Toxicity

      • I. G. Sipes, R. L. Fisher, P. F. Smith, E. R. Stine, A. J. Gandolfi, K. Brendel
      Pages 20-33

    5. Some Aspects of Cell Defense Mechanisms of Glutathione and Vitamin E During Cell Injury

      • D. J. Reed, G. A. Pascoe, K. Olafsdottir
      Pages 34-38

    6. Structure Activity Requirements for Induction of Peroxisomal Enzyme Activities in Primary Rat Hepatocyte Cultures

      • D. F. V. Lewis, B. G. Lake, T. J. B. Gray, S. D. Gangolli
      Pages 39-41

    7. Oxidative and Reductive Biotransformation of Chloroform in Mouse Liver Microsomes

      • E. Testai, F. Gramenzi, S. Di Marzio, L. Vittozzi
      Pages 42-44

    8. Effects of Subchronic Low-Protein Diet on Some Tissue Glutathione - Related Enzyme Activities in the Rat

      • J.-M. Warnet, I. Bakar-Wesseling, M. Thevenin, J. J. Serrano, A. Jacqueson, M. Boucard et al.
      Pages 45-49

  3. Mechanisms in Cancer Risk Assesment

    1. Front Matter

      Pages 51-51
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    2. Interorgan Shift of Nitrosamine Metabolism by Dietary Ethanol

      • O. D. Wiestler, A. von Deimling, E. von Hofe, I. Schmerold, E. Wiestler, P. Kleihues
      Pages 53-65

    3. Quantitative Evaluation of DNA-Binding Data In Vivo for Low-Dose Extrapolations

      • W. K. Lutz
      Pages 66-74

    4. Persistent Organ Damage and Cancer Production in Rats and Mice

      • P. Grasso
      Pages 75-83

    5. Sensitivity of DNA and Nucleotides to Oxidation by Permanganate and Hydrogen Peroxide

      • P. Sagelsdorff, W. K. Lutz
      Pages 84-88

    6. A Postlabelling Assay for N7-(2-Oxoethyl)Guanine, the Principal Vinyl Chloride-DNA Adduct

      • W. P. Watson, A. E. Crane, R. Davis, R. J. Smith, A. S. Wright
      Pages 89-92

    7. Comparison of Hydrocarbon – DNA Adducts Formed in Mouse and Human Skin Following Treatment with Benzo [A] Pyrene

      • W. P. Watson, R. J. Smith, K. R. Huckle, A. S. Wright
      Pages 93-98

    8. Combined Radiolabelling Distribution and Covalent DNA-Binding Studies to Discriminate Between a Carcinogen/Noncarcinogen Pair of Monoazo Dyes Related to the Hepatocarcinogen Butter Yellow (DAB)

      • R. H. Dashwood, R. D. Combes, J. Ashby
      Pages 99-101

  4. Mechanisms and Models of Teratogenesis

    1. Front Matter

      Pages 103-103
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    2. Teratogenicity Testing in Vitro: Status of Validation Studies

      • N. A. Brown
      Pages 105-114

    3. The Primate as a Model for Hazard Assessment of Teratogens in Humans

      • R. Korte, F. Vogel, I. Osterburg
      Pages 115-121
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Keywords

About this book

This supplement presents the papers submitted at the 27th meeting of the European Society of Toxicology, which was organised by the British Toxicology Society and held in Harrogate, England. As evident from the title of this book, the overall theme of the meeting was an exploration of some of the mechanisms of toxicity, as well as some models used in the investigation of toxic action. The topics dealt with can be grouped under four headings. The first of these, on the mechanisms involved in cell injury, was a joint symposium of the European Society of Toxicology and the Society of Toxicology of the United States of America. In the second group, mechanisms in carcinogen risk assessment were discussed. Mechanisms and models of teratogenesis was the subject of the third group of invited papers. Finally, a workshop on safety evaluation of biotechnological products dealt with present and future problems which this new area of technology poses for toxicologists. Short communications on recent studies and developments in toxicological techniques which were presented at the meeting are also included in this volume.

Editors and Affiliations

  • Department of Pharmacology and Therapeutics, Trinity College, University of Dublin, Dublin 2, Ireland

    Claire M. Chambers, Philip L. Chambers

  • Royal Postgraduate Medical School, London, UK

    Donald S. Davies

Bibliographic Information

  • Book Title: Mechanisms and Models in Toxicology

  • Book Subtitle: Proceedings of the European Society of Toxicology Meeting Held in Harrogate, May 27–29, 1986

  • Editors: Claire M. Chambers, Philip L. Chambers, Donald S. Davies

  • Series Title: Archives of Toxicology

  • DOI: https://doi.org/10.1007/978-3-642-72558-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1987

  • Softcover ISBN: 978-3-540-17614-5Published: 23 June 1987

  • eBook ISBN: 978-3-642-72558-6Published: 06 December 2012

  • Series ISSN: 0171-9750

  • Edition Number: 1

  • Number of Pages: VIII, 365

  • Number of Illustrations: 23 b/w illustrations

  • Topics: Pharmacology/Toxicology, Pharmacy

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