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The Reeler Mouse as a Model of Brain Development

  • Book
  • © 1998

Overview

Authors:
  1. Catherine Lambert de Rouvroit

    1. Neurobiology Unit, University of Namur Medical School, Namur, Belgium

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    You can also search for this author in PubMed   Google Scholar

  2. André M. Goffinet

    1. Neurobiology Unit, University of Namur Medical School, Namur, Belgium

    View author publications

    You can also search for this author in PubMed   Google Scholar

Part of the book series: Advances in Anatomy, Embryology and Cell Biology (ADVSANAT, volume 150)

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Table of contents (5 chapters)

  1. Front Matter

    Pages I-XI
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  2. Brain Development in Normal and reeler Mice: the Phenotype

    • Catherine Lambert de Rouvroit, André M. Goffinet
    Pages 1-26

  3. Genetics of reeler and Genomics of reelin

    • Catherine Lambert de Rouvroit, André M. Goffinet
    Pages 27-39

  4. Topography and Cellular Localization of reelin mRNA and Protein Expression During Brain Development

    • Catherine Lambert de Rouvroit, André M. Goffinet
    Pages 41-58

  5. The reeler Mutation and Brain Evolution

    • Catherine Lambert de Rouvroit, André M. Goffinet
    Pages 59-71

  6. A Model of Cortical Development Inspired by Reeler: Facts and Hypotheses

    • Catherine Lambert de Rouvroit, André M. Goffinet
    Pages 73-88

  7. Back Matter

    Pages 89-108
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Keywords

About this book

Only five years ago, nobody in his right mind would have consid­ ered publishing a book on reeler as a model for brain develop­ ment. Although this interesting mutation has been with us for half a century, it is fair to say that, in spite of a wave of enthusiasm in the late sixties and early seventies, generated primarily by Sidman, Caviness and colleagues, studies of reeler mice fell pro­ gressively out of fashion during the next two decades. All that changed almost overnight when the cloning of the reeler gene, dubbed reelin, was reported in Tom Curran's laboratory in 1995. The fact that the same gene was identified at the same time independently by two other groups using positional cloning sug­ gested strongly that reelin was the right candidate. Although the key experiments of transgenic rescue have not been made (and perhaps will never be), the equation "reeler is reelin" has been established beyond reasonable doubt, as alterations of the reelin gene and/or its expression have been found in at least five alleles of reeler and in the mutation Shaking Rat Kawasaki (SRK), an ortholog of reeler.

Authors and Affiliations

  • Neurobiology Unit, University of Namur Medical School, Namur, Belgium

    Catherine Lambert de Rouvroit, André M. Goffinet

Bibliographic Information

  • Book Title: The Reeler Mouse as a Model of Brain Development

  • Authors: Catherine Lambert de Rouvroit, André M. Goffinet

  • Series Title: Advances in Anatomy, Embryology and Cell Biology

  • DOI: https://doi.org/10.1007/978-3-642-72257-8

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1998

  • Softcover ISBN: 978-3-540-64674-7Published: 28 September 1998

  • eBook ISBN: 978-3-642-72257-8Published: 12 March 2013

  • Series ISSN: 0301-5556

  • Series E-ISSN: 2192-7065

  • Edition Number: 1

  • Number of Pages: XI, 108

  • Number of Illustrations: 19 b/w illustrations

  • Topics: Neurosciences

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