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The Cerebral Perivascular Cells

  • Book
  • © 1998

Overview

Authors:
  1. D. N. Angelov

    1. Institut für Anatomie der Universität zu Köln, Köln, Germany

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  2. M. Walther

    1. Institut für Anatomie der Universität zu Köln, Köln, Germany

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  3. W. F. Neiss

    1. Institut für Anatomie der Universität zu Köln, Köln, Germany

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  4. M. Streppel

    1. Klinik für Hals-, Nasen- und Ohrenheilkunde der Universität zu Köln, Köln, Germany

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  5. O. Guntinas-Lichius

    1. Klinik für Hals-, Nasen- und Ohrenheilkunde der Universität zu Köln, Köln, Germany

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Part of the book series: Advances in Anatomy, Embryology and Cell Biology (ADVSANAT, volume 147)

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Table of contents (5 chapters)

  1. Front Matter

    Pages I-XI
    Download chapter PDF

  2. Introduction

    • D. N. Angelov, M. Walther, W. F. Neiss, M. Streppel, O. Guntinas-Lichius
    Pages 1-7

  3. Materials and Methods

    • D. N. Angelov, M. Walther, W. F. Neiss, M. Streppel, O. Guntinas-Lichius
    Pages 9-19

  4. Results

    • D. N. Angelov, M. Walther, W. F. Neiss, M. Streppel, O. Guntinas-Lichius
    Pages 21-61

  5. Discussion

    • D. N. Angelov, M. Walther, W. F. Neiss, M. Streppel, O. Guntinas-Lichius
    Pages 63-73

  6. Summary

    • D. N. Angelov, M. Walther, W. F. Neiss, M. Streppel, O. Guntinas-Lichius
    Pages 75-76

  7. Back Matter

    Pages 77-90
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Keywords

About this book

Following an exhaustive literature review on the global issue of intracerebral presentation of antigen, this monograph summarizes results from voluminous work to establish which indigenous cerebral cells might present (auto)antigen to the immune system and thus initiate an (auto)immune reaction. Employing the combination of (a) a lesion model in which neuronal degeneration and neuronophagia are caused without disruption of the blood--brain barrier, (b) stable labeling of the neuronophages via phagocytosis of the permanent nontoxic fluorescent marker Fluoro-Gold from preloaded neurons, and (c) immunocytochemical identification of all FG-labeled brain neuronophages, the authors provide evidence that the only cells in the rat CNS which can be regarded as the resident antigen presenting cells of the brain are perivascular cells.

Authors and Affiliations

  • Institut für Anatomie der Universität zu Köln, Köln, Germany

    D. N. Angelov, M. Walther, W. F. Neiss

  • Klinik für Hals-, Nasen- und Ohrenheilkunde der Universität zu Köln, Köln, Germany

    M. Streppel, O. Guntinas-Lichius

Bibliographic Information

  • Book Title: The Cerebral Perivascular Cells

  • Authors: D. N. Angelov, M. Walther, W. F. Neiss, M. Streppel, O. Guntinas-Lichius

  • Series Title: Advances in Anatomy, Embryology and Cell Biology

  • DOI: https://doi.org/10.1007/978-3-642-72251-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1998

  • Softcover ISBN: 978-3-540-64638-9Published: 21 September 1998

  • eBook ISBN: 978-3-642-72251-6Published: 07 March 2013

  • Series ISSN: 0301-5556

  • Series E-ISSN: 2192-7065

  • Edition Number: 1

  • Number of Pages: XI, 90

  • Number of Illustrations: 23 b/w illustrations

  • Topics: Neurosciences, Cell Biology

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