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Clinical Applications of Immunotoxins

  • Book
  • © 1998

Overview

Editors:
  1. Arthur E. Frankel

    1. Hollings Cancer Center, Medical University of South Carolina, Charleston, USA

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Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 234)

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Table of contents (8 chapters)

  1. Front Matter

    Pages i-ix
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  2. Introduction

    • I. FitzGerald, I. Pastan, J. Robertus
    Pages 1-11

  3. The Emerging Role of Ricin A-Chain Immunotoxins in Leukemia and Lymphoma

    • A. Engert, E. A. Sausville, E. Vitetta
    Pages 13-33

  4. Clinical Trials with Blocked Ricin Immunotoxins

    • J. E. O’Toolei, D. Esseltine, T. J. Lynch, J. M. Lambert, M. L. Grossbard
    Pages 35-56

  5. Saporin Immunotoxins

    • D. J. Flavell
    Pages 57-61

  6. Diphtheria Toxin Fusion Proteins

    • F. M. Foss, M. N. Saleh, J. G. Krueger, J. C. Nichols, J. R. Murphy
    Pages 63-81

  7. Clinical Trials with Pseudomonas Exotoxin Immunotoxins

    • L. H. Pai, I. Pastan
    Pages 83-96

  8. Immunotoxins for Brain Tumor Therapy

    • E. H. Oldfield, R. J. Youle
    Pages 97-114

  9. Conclusions

    • A. E. Frankel, M. C. Willingham
    Pages 115-120

  10. Back Matter

    Pages 121-124
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Keywords

About this book

1 2 D. FITZGERALDI, I. PASTAN , and J. ROBERTUS Introduction . . . . . . . . . . . . . I 2 Toxin Structure-Function Properties 2 2. 1 Functions. . . . . . . . . . . . . . . . . . . . . . . . 2 2. 2 Binding. . . . . . . . . . . . . . . . . . . . . . . . . 3 3 Intracellular Processing - Cleavage and Reduction . . . . . . 4 3. 1 Cytosolic Activity . . . . . . . . . . . . . . . . 5 4 Immunotoxin Design and Testing. 6 5 Conclusion. . 8 References. . . . . 8 1 Introduction While various treatment approaches for cancer include reversal of the transformed phenotype, stimulation of immune responses, inhibition of metastatic spread and deprivation of key nutrients, the goal of immunotoxin treatment is the direct killing of malignant cells. Because they are enzymatic proteins that act catalytically to kill cells, bacterial and plant toxins are often employed as the cell-killing component of immunotoxins. Here we provide background information into the structure-func­ tion relationships of toxins and discuss how they can be combined with cell-binding antibodies or other ligands to generate immunotoxins. Bacterial and plant toxins (e. g. , diphtheria toxin, Pseudomonas exotoxin and ricin) are among the most toxic substances known. However, because they bind to cell surface receptors that are present on most normal cells, unmodified toxins are generally useless as anti-cancer agents. To convert toxins into more selective agents, their binding domains are either eliminated or disabled and replaceq with cell­ binding antibodies that are tumor-selective.

Editors and Affiliations

  • Hollings Cancer Center, Medical University of South Carolina, Charleston, USA

    Arthur E. Frankel

Bibliographic Information

  • Book Title: Clinical Applications of Immunotoxins

  • Editors: Arthur E. Frankel

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-642-72153-3

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1998

  • Softcover ISBN: 978-3-642-72155-7Published: 10 December 2011

  • eBook ISBN: 978-3-642-72153-3Published: 06 December 2012

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: IX, 122

  • Number of Illustrations: 5 b/w illustrations, 1 illustrations in colour

  • Topics: Immunology, Cancer Research, Hematology, Pharmacology/Toxicology

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