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Inhibitors of Cell Growth

  • Book
  • © 1998

Overview

Editors:
  1. Alvaro Macieira-Coelho

    1. INSERM, Versailles, France

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  • This book covers the whole range of inhibitors of cell growth, and considers therapeutic applications, development and structure-function relationships.

Part of the book series: Progress in Molecular and Subcellular Biology (PMSB, volume 20)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-xii
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  2. Introduction

    • Alvaro Macieira-Coelho
    Pages 1-9

  3. The Growth-Inhibitory Effects of TGFβ

    • Rafael E. Herrera
    Pages 11-24

  4. Big Brothers Are Watching: the Retinoblastoma Family and Growth Control

    • Peter Stiegler, Antonio Giordano
    Pages 25-42

  5. The Growth-Regulatory Role of p21 (WAF1/CIP1)

    • Andrei L. Gartel, Angela L. Tyner
    Pages 43-71

  6. Mechanisms of Cell Cycle Blocks at the G2/M Transition and Their Role in Differentiation and Development

    • Michael R. A. Mowat, Nancy Stewart
    Pages 73-100

  7. Mechanisms of Interferon Action

    • Douglas W. Leaman
    Pages 101-142

  8. Growth-Inhibiting N-Substituted Endogenous Peptides

    • Kjell Elgjo, Karl Ludwig Reichelt, David S. Gembitsky
    Pages 143-159

  9. Endogenous Angiogenesis Inhibitors: Angiostatin, Endostatin, and Other Proteolytic Fragments

    • Yihai Cao
    Pages 161-176

  10. Inhibitors of Preadipocyte Replication: Opportunities for the Treatment of Obesity

    • James L. Kirkland, Charles H. Hollenberg
    Pages 177-195

  11. Growth Inhibitors for Mammary Epithelial Cells

    • Ralf Brandt, Andreas D. Ebert
    Pages 197-248

  12. Growth Inhibition of Human Fibroblasts in Vitro

    • Alvaro Macieira-Coelho
    Pages 249-270

  13. Back Matter

    Pages 271-272
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Keywords

About this book

The containment of cell growth is at the core of the homeostatic regulation of metazoans, and considerable progress has been made in the understanding of how this is achieved. Most knowledge comes from the isolation of molecu­ les with positive and negative regulatory effects on cell proliferation, and most emphasis so far has been on these molecules. Some of these molecules are already available for therapeutic purposes, and others look promising in this respect. This volume gives examples of such approaches. The understanding of the control of cell growth is also fundamental to grasp phylogenic and ontogenic development. Why organisms have developed increasingly sophisticated mechanisms that control their size and that of their organs, how different cells originate, some destined for renewal and repair, others for specialized functions in a postmitotic state or evolving through division, others like the germinal cells waiting for the signal to start another organism. There is one mechanism of growth containment, however, about which we know very little. It concerns the structural characteristics of the cell, i.e. the relationship between structure and function. How structure can change the response to identical signals. The positive and negative growth regulators may be conserved, but the structure and organization of the genetic material and of other cell components differ widely and are responsible to a great extent for the differences in cell proliferative behaviour.

Editors and Affiliations

  • INSERM, Versailles, France

    Alvaro Macieira-Coelho

Bibliographic Information

  • Book Title: Inhibitors of Cell Growth

  • Editors: Alvaro Macieira-Coelho

  • Series Title: Progress in Molecular and Subcellular Biology

  • DOI: https://doi.org/10.1007/978-3-642-72149-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1998

  • Softcover ISBN: 978-3-642-72151-9Published: 13 June 2012

  • eBook ISBN: 978-3-642-72149-6Published: 06 December 2012

  • Series ISSN: 0079-6484

  • Series E-ISSN: 2197-8484

  • Edition Number: 1

  • Number of Pages: XII, 272

  • Number of Illustrations: 17 b/w illustrations

  • Topics: Cell Biology, Cancer Research, Biochemistry, general, Oncology

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